Immunocontraception of Eastern Grey kangaroos (Macropus giganteus) with recombinant brushtail possum (Trichosurus vulpecula) ZP3 protein

Kitchener, Anne L.; Harman, Amanda; Kay, D. J.; McCartney, Carmen A.; Mate, Karen E.; Rodger, John C.

doi:10.1016/j.jri.2008.10.004

Cited by 26 publications

(15 citation statements)

References 23 publications

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“…Long‐term follow‐up studies of the vaccinated feral horses and white‐tailed deers revealed no significant deleterious effects on the health of the immunized animals, except oophoritis 49–51 . In addition to porcine ZP, the efficacy of E. coli ‐expressed recombinant brushtail possum ( Trichosurus vulpecula ) ZP3 to curtail fertility of marsupials, which are considered as pests in Australia and New Zealand, has also been demonstrated 52,53 . The above studies are suggestive of enormous potential of the ZP‐based contraceptive vaccines for wildlife management, where observed oophoritis may not be a deterrent factor.…”

Section: Discussionmentioning

confidence: 88%

Contraceptive Vaccines Based on the Zona Pellucida Glycoproteins for Dogs and Other Wildlife Population Management

Gupta

Srinivasan

Suman

et al. 2011

American J Rep Immunol

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Citation Gupta SK, Srinivasan VA, Suman P, Rajan S, Nagendrakumar SB, Gupta N, Shrestha A, Joshi P, Panda AK. Contraceptive vaccines based on the zona pellucida glycoproteins for dogs and other wildlife population management. Am J Reprod Immunol 2011; 66: 51–62 Zona pellucida (ZP) glycoproteins, by virtue of their critical role in fertilization, have been proposed as candidate antigens for the development of contraceptive vaccines. In this review, the potential of a ZP‐based contraceptive vaccine for the management of wildlife population, with special reference to street dogs, is discussed. Immunization of various animal species, including female dogs, with native porcine ZP led to inhibition of fertility, which was associated with the ovarian dysfunction. Immunization of female dogs with Escherichia coli‐expressed recombinant dog ZP glycoprotein‐3 (ZP3) either coupled to diphtheria toxoid or expressed as fusion protein with ‘promiscuous’ T non‐B‐cell epitope of tetanus toxoid also led to inhibition of fertility. To improve the contraceptive efficacy of ZP‐based contraceptive vaccine, various groups are working on improving the immunogen, use of DNA vaccine as prime‐boost strategy, and delivering the zona proteins/peptides presented on either virus‐like particles or entrapped in microsphere. Host‐specific live vectors such as ectromelia virus and cytomegalovirus have also been used to deliver mouse ZP3 in mice. Various studies show the enormous potential of the ZP‐based vaccine for the management of wildlife population, where permanent sterilization may be desirable.

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Section: Discussionmentioning

confidence: 88%

Contraceptive Vaccines Based on the Zona Pellucida Glycoproteins for Dogs and Other Wildlife Population Management

Gupta

Srinivasan

Suman

et al. 2011

American J Rep Immunol

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“…Recombinant ZP peptides have not been widely tested in wild animals. Infertility has been successfully induced with recombinant ZP in non‐human primates, brushtail possums, and Eastern Grey kangaroos . Immunization with native PZP was shown to cause a greater reduction (87%) in fawning than the recombinant rabbit ZP (0–33%) in deer, although this could possibly be due to low homology between deer and rabbit ZP .…”

Section: Pzp Vaccinementioning

confidence: 99%

Immunocontraception for Animals: Current Status and Future Perspective

Naz

Saver

2015

American J Rep Immunol

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An alternative to surgical sterilization for fertility control of animals (wild, zoo, farm, and domestic) is needed to prevent problems related to overpopulation, including culling and relocation. A PubMed and Google Scholar database search was conducted using the keywords 'contraceptive vaccine animals,' 'immunocontraception animals,' 'non-surgical sterilization animals,' 'PZP vaccine,' and 'GnRH vaccine.' The searches from 1972 to 2015 yielded over 1500 publications. These articles were read, and 375 were selected for detailed analysis. Articles referenced in these publications were also thoroughly examined. PZP and GnRH contraceptive vaccines (CVs) have been extensively investigated for fertility control of wild, zoo, farm, and domestic animal populations. Both vaccines have shown tremendous success with PZP vaccines taking the lead. Novel technologies and targets are being developed to improve existing vaccines and generate second-generation CVs. Single-shot vaccines, which can be delivered remotely, will greatly advance the field of immunocontraception for animal use with potential human application.

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“…All the immunized animals became pregnant upon mating once the levels were less than the 2 × 10 3 antibody units. Significant curtailment of fertility was also observed by using recombinant possum ZP3 in grey kangaroos [45, 46]. Though the results were quite exciting, histological examination of ovaries of immunized animals revealed the presence of atretic follicles with degenerating oocytes.…”

Section: Immunocontraceptionmentioning

confidence: 99%

Immunocontraceptives: New Approaches to Fertility Control

Kaur

Prabha

2014

BioMed Research International

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The rapidly increasing global population has bowed the attention of family planning and associated reproductive health programmes in the direction of providing a safe and reliable method which can be used to limit family size. The world population is estimated to exceed a phenomenal 10 billion by the year 2050 A.D., thus presenting a real jeopardy of overpopulation with severe implications for the future. Despite the availability of contraceptive methods, there are over one million elective abortions globally each year due to unintended pregnancies, having devastating impact on reproductive health of women worldwide. This highlights the need for the development of newer and improved contraceptive methods. A novel contraceptive approach that is gaining substantial attention is “immunocontraception” targeting gamete production, gamete outcome, or gamete function. Amongst these, use of sperm antigens (gamete function) seems to be an exciting and feasible approach. However, the variability of immune response and time lag to attain titer among vaccinated individuals after active immunization has highlighted the potential relevance of preformed antibodies in this league. This review is an attempt to analyze the current status and progress of immunocontraceptive approaches with respect to their establishment as a future fertility control agent.

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Immunocontraception of Eastern Grey kangaroos (Macropus giganteus) with recombinant brushtail possum (Trichosurus vulpecula) ZP3 protein

Cited by 26 publications

References 23 publications

Contraceptive Vaccines Based on the Zona Pellucida Glycoproteins for Dogs and Other Wildlife Population Management

Contraceptive Vaccines Based on the Zona Pellucida Glycoproteins for Dogs and Other Wildlife Population Management

Immunocontraception for Animals: Current Status and Future Perspective

Immunocontraceptives: New Approaches to Fertility Control

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