Immunocompetent Cells in the Blood of Immunized Chickens

Seto, Frank

doi:10.3382/ps.0491673

Cited by 15 publications

(9 citation statements)

References 28 publications

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“…Solomon (1968) detected opsonising antibody at hatching, following immunisation of the embryo, showing that the chick becomes immuno-competent just before hatching. It is not until the 3rd to 5th week after hatching, however, that the various cellular components of the chick immune system are fully functional and in their final locations, and no longer dependent on bone marrow, bursa or thymus (Cooper et al, 1966;Seto and Henderson, 1968;Seto, 1970).…”

Section: Introductionmentioning

confidence: 99%

The ontogeny of the Humoral immune response toE. colivaccine and to sheep red blood cells in young chicks

Peleg¹,

Heller²,

Pitkovsky³

1985

Avian Pathology

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Section: Introductionmentioning

confidence: 99%

The ontogeny of the Humoral immune response toE. colivaccine and to sheep red blood cells in young chicks

Peleg¹,

Heller²,

Pitkovsky³

1985

Avian Pathology

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“…The earliest studies on antibody response by transferred cells suffered from allogeneic rejection (6, 7). To avoid such rejection, newly hatched and embryonic recipients have been used to demonstrate antibody production by spleen, bone marrow, and thymus cells from immunized and normal donors (8)(9)(10)(11)(12)(13)(14)(15)(16). In these models, however, the transplanted cells induced a graft-vs.-host reaction in the young recipients.…”

mentioning

confidence: 99%

Ontogeny of Bursal Function in Chicken

Toivanen

Good

1972

The Journal of Experimental Medicine

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During our studies on the progenitor or stem cell responsible for humoral immunity (1, 2) it became evident that the organ distribution of the stem cell does not parallel the distribution of immunocompetent cells. In the present work, we have studied the occurrence of immunocompetent cells in different chicken tissues during different stages of ontogeny. For this purpose, immunoeompetent cells for humoral immunity are considered those cells which react with antigens and produce antibodies, without defining how many cell types are involved.Previously, different methods have been applied to studies of the immunocompetent cells in avian tissues. Studies by several investigators (3-5) have demonstrated that spleen cells of immunized adult and young chickens adhere and lyse sheep red blood cells (SRBC), ~ whereas cells taken from bursa of Fabricius are inactive in this respect. The earliest studies on antibody response by transferred cells suffered from allogeneic rejection (6, 7). To avoid such rejection, newly hatched and embryonic recipients have been used to demonstrate antibody production by spleen, bone marrow, and thymus cells from immunized and normal donors (8)(9)(10)(11)(12)(13)(14)(15)(16). In these models, however, the transplanted cells induced a graft-vs.-host reaction in the young recipients. Graft-vs.-host reactions were also obtained when hormonally bursectomized recipients were used (13,17). In surgically bursectomized chickens, bursal transplants, as such or in a diffusion chamber, were found to increase antibody synthesis if the chickens were stimulated within 3 days after transplantation (18-21).The histoincompatibility reactions can be mostly avoided by having birds isogeneic at the B locus. Using this model, Orlans and Rose (22) showed that preimmunized

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“…These antigen sensitive cells are infrequent in unimmunized birds. Within a few days after immunization, however, they appear in abundance in the spleen and blood stream where they persist for weeks (Seto, 1970b). When transferred to embryonic hosts they remain quiescent but can be activated by antigen to form PFC's and HA-forming cells.…”

Section: Discussionmentioning

confidence: 99%

Antigen Responsive Cells in Unprimed and Antigen-Primed Chickens

Seto

1981

Poultry Science

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The frequency of antigen responsive cells (ARC) specific for mouse red blood cells (MRBC), as measured with the cell transfer assay, was consistently high in the spleen and blood of MRBC-immunized chickens but negligible in unprimed juvenile birds. Practically all of the adoptive antibody formation in the host embryos could be attributed to the presence of ARC's in the cell suspensions from immunized birds and very little to passively acquired donor plaque-forming cells (PFC). When the spleen and blood cells from unprimed donors were retested in the in vivo immune assay, as found before, the host embryos failed to respond to a single MRBC exposure given at the time of cell transfer. However, substantial splenic PFC formation occurred in response to a second MRBC injection given four days later. In addition to the spleen, the peripheral blood of the unprimed and antigen-primed chicken represents a significant reservoir of immunocyte precursors.

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Immunocompetent Cells in the Blood of Immunized Chickens

Cited by 15 publications

References 28 publications

The ontogeny of the Humoral immune response toE. colivaccine and to sheep red blood cells in young chicks

The ontogeny of the Humoral immune response toE. colivaccine and to sheep red blood cells in young chicks

Ontogeny of Bursal Function in Chicken

Antigen Responsive Cells in Unprimed and Antigen-Primed Chickens

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