Immunocompetent cells in amalgam‐associated oral lichenoid contact lesions

Laine, Juhani; Konttinen, Yrjö T.; Beliaev, Nikita; Happonen, Risto‐Pekka

doi:10.1111/j.1600-0714.1999.tb02008.x

Cited by 34 publications

(25 citation statements)

References 28 publications

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“…The difference in mean LI among the study groups showed statistical significance. These observations were consistent with that of McCartan and Lamey,[4] Regezi et al .,[10] Laine et al .,[11] who reported statistically significant higher number of LC in LP. However they did not observe significant difference of CD1a LI between the different layers of the epithelium of LP.…”

Section: Discussionsupporting

confidence: 93%

Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study

et al. 2014

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Aim:The aim of this study is to identify and evaluate Langerhans cell (LC) in lichen planus (LP), lichenoid mucositis (LM) and normal mucosa (NM) using CD1a monoclonal antibody immunohistochemically.Materials and Methods:A total of 15 cases of oral lichen planus and 15 cases of LM were selected based on clinical examination and confirmed by histopathological analysis. The biopsies from the 10 patients were taken from normal buccal mucosa as control. Paraffin blocks of tissue were made, which are used for routine hematoxylin and eosin staining and immunohistochemical staining using biotin streptavidin methods (CD1a monoclonal antibody). Analysis of CD1a expression was performed by evaluating the labeling index (LI) for each slide.Results:The mean CD1a LI for LP was significantly higher than that of LM and NM in the basal and supra basal layer. The mean CD1a positive cells in the connective tissues for LP were higher than that of LM and NM.Conclusion:This study clearly demonstrates a statistically significant increase in number of LC in LP than in LM, indicating the possible different immunopathogenic mechanisms.

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Section: Discussionsupporting

confidence: 93%

Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study

et al. 2014

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“…Mercury compounds may also cause musculoskeletal and neuropsychological symptoms (9). It has been proven that contact allergy to mercury is directly correlated with the incidence of oral lichen planus (5). The term 'oral lichenoid lesion' is commonly used to describe such lesions that develop as a consequence of dental restorations (1,5,9).…”

Section: Discussionmentioning

confidence: 99%

“…It has been proven that contact allergy to mercury is directly correlated with the incidence of oral lichen planus (5). The term 'oral lichenoid lesion' is commonly used to describe such lesions that develop as a consequence of dental restorations (1,5,9). The clinical appearances and histopathologic changes associated with oral lichenoid lesions and oral lichen planus are similar.…”

Section: Discussionmentioning

confidence: 99%

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Oral leukoplakia associated with amalgam restorations

Gönen

Asan

Etöz

et al. 2016

Journal of Oral Science

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IntroductionOral leukoplakia (OL) is defined by the World Health Organization as "a white patch or plaque of the oral mucosa that cannot be characterized clinically or pathologically as any other disease" (1). The prevalence of OL ranges from 0.5 to 3.4% with a peak incidence rate in individuals older than 50 years. According to the literature, most oral carcinoma cases are associated with, or preceded by, clinically detectable premalignant lesions such as OL. The malignant transformation rate of OL is reported to be in the range of 0.1 to 17% (2).The etiological factors most commonly associated with OL have been smoking, alcohol abuse, candidiasis, HPV infection, iron deficiency, and low serum levels of vitamin A and beta-carotene (3). Zinsser-Cole Engman syndrome, a genodermatosis commonly known as dyskeratosis congenita, includes oral manifestations such as OL. Many different non-surgical and surgical modalities such as conventional surgery, electrocauterization, laser ablation, cryosurgery, and medications such as vitamin A, vitamin B, and bleomycin, have been reported for treatment of OL (4).Dental amalgams remain the most commonly used posterior restorative material in dental practice. A relationship has been established between contact allergy to mercury and oral lichen planus (5). Although amalgamrelated conditions such as burning mouth, xerostomia, and musculoskeletal and neuropsychological symptoms have been reported, the relationship between amalgam and OL has not yet been examined.This report documents a patient with OL lesions who showed a positive skin patch test reaction to amalgam and who subsequently recovered after his amalgam restorations had been removed and replaced with a different material. Case ReportA 21-year-old male was referred to the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, with suspected OL. His major complaint was a bilateral burning sensation in the buccal mucosa. The patient had previously received cryotherapy and laser treatment at a dermatology clinic, but the OL lesions had not healed. Intraoral examination revealed white lesions bilaterally affecting the buccal mucosa and tongue (Figs. 1-3). The patient had no systemic disease and no history of tobacco or alcohol consumption. In order to confirm the histological nature of the lesion, an incisional biopsy

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“…Studies with biopsies showed increased mercury levels in the adjacent tissue and increased counts of mononuclear cells. These in- creased cell counts are believed to be associated with a type 4 allergic reaction in some patients and with an unspecific reaction of the immune system in others [125][126][127]. When amalgam is removed, the alterations of the oral mucous membranes are usually reversible [128][129][130][131].…”

Section: Hypersensitivity In Humansmentioning

confidence: 99%

Immunological effects of mercury (IUPAC Technical Report)

Schwenk

Klein

Templeton

2009

Pure and Applied Chemistry

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Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the Immunological effects of mercury (IUPAC Technical Report)Abstract: Various chemical species of mercury differ considerably with regard to their route of absorption and their distribution in the body, yet many of them and their metabolites exhibit high-affinity binding to sulfanyl groups of proteins. Among all metals, mercury appears to have the most diverse effects on the immune system. Depending on the animal species and experimental conditions, mercury compounds may cause immunosuppression or immunostimulation, autoimmune reactions, or hypersensitivity. Mercury-sensitive strains of rats and mice are often used as model organisms to study the time course and events in autoimmunity. Within about 14 days after onset of oral mercury(II) exposure, levels of immunoglobulins E and G (IgE and IgG) increase, including autoantibodies to biomolecules such as laminin and fibrillarin. Antigen-antibody complexes are formed and are the cause of subsequent autoimmune diseases of blood vessels and organs. Mercury may induce local mercury hypersensitivity in humans, but the evidence for a role of mercury in autoimmune disease of humans is at best weak. Models for the immune effects of mercury are presented on the basis of current knowledge.

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Immunocompetent cells in amalgam‐associated oral lichenoid contact lesions

Cited by 34 publications

References 28 publications

Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study

Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study

Oral leukoplakia associated with amalgam restorations

Immunological effects of mercury (IUPAC Technical Report)

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