Immunochemical quantitation of acute phase reactive proteins in myocardial infarction

Agostoni, A; Vergani, Carlo; Stabilini, R.; Marasini, Bianca; Arcidiacono, R; Sbaffi, Andrea; Binaghi, P

doi:10.1016/0002-8703(70)90096-7

Cited by 30 publications

(11 citation statements)

References 5 publications

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“…Owen et al5) noticed the peak level on the third day of coronary attack but Agostoni et al8),13) have reported a rise of Hp level from the third day and the peak level reaching on the 6th day and values returning to normal in about 2 months. The observations in the present study were in conformity with those of Agostoni et al 8) The rise of Hp level was more in male patients as compared to females though in control cases Hp level was more or less the same in either sex. This disparity could be accounted for by the hormonal make up of the females which provided a protective role against IHD hence the incidence of the disease as well as its severity is low in females as compared to their male counterparts.14)…”

Section: Discussionsupporting

confidence: 93%

Serum Haptoglobin in Cases of Ischemic Heart Diseases

1980

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SUMMARYSerum haptoglobin (Hp) was estimated in 76 cases of ischemic heart diseases (IHD) and 151 healthy individuals. A statistically significant rise in Hp level was observed in IHD cases. The rise was independent on the age and blood type of the cases but was more predominent in males as compared to females.The increase in Hp level was noticed after the third day of coronary attack and peak level was obtained between the 7th to 9th day. Hp level was closely related to the degree of myocardial damage. No rise was seen in cases of angina whereas maximum rise was noticed in patients with multiple infarcts.Hp phenotype pattern in IHD cases was not different from that of control cases. Additional Indexing Words: HaptoglobinsImportance in myocardial infarct ERUM haptoglobin level has been used as an indicator of the degree of activity of various diseases particularly those characterized by the tissue destruction,1),2) malignancy,3) renal disorders,4) and myocardial infarction. Increasing levels of haptoglobin (Hp) in ischemic heart diseases (IHD) have been observed by different workers5)-9) and a close correlation between the Hp level and extent of heart damage has been reported.The present communication deals with the observations on serum Hp level in cases of IHD and its diagnostic and prognostic significance in these cases.

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Section: Discussionsupporting

confidence: 93%

Serum Haptoglobin in Cases of Ischemic Heart Diseases

1980

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“…Changes in this acute phase reactant have been described in acute inflammatory settings such as myocardial infarction. In acute myocardial infarction, peak AAG increases of 4545% occur during the first 3-4 days after patients experience the infarction (16,17). Although these changes have been sug- gested to result in alterations in CBZ binding, our data indicate that the free fractions of CBZ and CBZ-E do not decrease as would be expected, but rather remain unchanged after epilepsy surgery.…”

Section: Discussionmentioning

confidence: 43%

Evaluation of Carbamazepine and Carbamazepine‐Epoxide Protein Binding in Patients Undergoing Epilepsy Surgery

et al. 1996

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Carbamazepine (CBZ) serum concentrations increase after epilepsy surgery. A possible mechanism may be acute changes in protein binding, specifically those involving the acute phase reactant alpha(1)-acid glycoprotein (AAG). We prospectively evaluated 16 adults (11 receiving CBZ) with epilepsy (mean age 30 +/- 9.9 years, 8 women and 8 men) undergoing temporal lobe resections and characterized AAG, albumin, CBZ, and CBZ-epoxide (CBZ-E) free fractions over time. AAG, ALB, CBZ, and CBZ-E free fractions were determined before surgery (baseline) and on postoperative days 1-5, 14, and 30. AAG was measured with a radial immunodiffusion assay method, CBZ and CBZ-E serum concentrations were determined by high-performance liquid chromatography (HPLC). Free fractions of CBZ and CBZ-E were calculated as the ratio of unbound (determined after ultracentrifugation) to total serum drug concentrations. Statistical analysis included analysis of variance (ANOVA) and Student's t test for paired data when appropriate, with significance assigned at p<0.05. All data are mean +/- SD. AAG concentrations increased significantly from baseline 61.9 +/- 21.3 mg/dl), peaking at postoperative day 3 (116.8 +/- 20.6 mg/gl) and decreasing to baseline levels between days 14 and 30. CBZ serum concentrations were significantly increased in the immediate postoperative period (day 3), but albumin concentrations and CBZ and CBZ-E free fractions did not differ significantly between baseline and the postoperative time points. Temporal lobe resection results in an acute phase reaction which is manifested in part by significant changes in AAG. Although CBZ and CBZ-E total serum concentrations increased significantly in the immediate postoperative period, epilepsy surgery did not appear to result in significant overall changes in drug binding to plasma proteins.

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“…Elevated serum concentrations of haptoglobin also occur in the setting of pregnancy (38), myocardial infarction (39), and cancer (39,40). In a variety ofmalignancies, haptoglobin concentration correlates with disease progression (40)(41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis.

et al. 1993

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Angiogenesis is an important process in chronic inflammatory diseases. We observed that sera from patients with systemic vasculitis stimulated angiogenesis in an in vitro model using human umbilical vein endothelial cells cultured on a basement membrane (Matrigel) substrate. After 40% ammonium sulfate precipitation, angiogenic activity remained in the low molecular weight fraction and could be inactivated by heat. SDS-page of serum FPLC fractions exhibiting maximal angiogenic activity demonstrated two prominent species of 45 and 16-20 kD in patients' sera. These bands were much less apparent in sera obtained from control subjects. Amino-terminal sequencing of the 45-kD protein demonstrated that it was haptoglobin. Purified haptoglobin stimulated angiogenesis in a dose-dependent manner. The angiogenic activity of vasculitis patients' sera was partially inhibited by an antihaptoglobin antibody. Furthermore, serum haptoglobin levels in vasculitis patients correlated both with disease and angiogenic activity. Haptoglobin angiogenic activity was confirmed in two in vivo models using an implanted disc and a subcutaneous injection of basement membrane. Stimulation ofangiogenesis is a newly recognized biological function of haptoglobin. The increased levels of haptoglobin found in chronic inflammatory conditions may play an important role in tissue repair. In systemic vasculitis, haptoglobin might also compensate for ischemia by promoting development of collateral vessels. (J. Clin. Invest. 1993. 91:977-985.)

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Immunochemical quantitation of acute phase reactive proteins in myocardial infarction

Cited by 30 publications

References 5 publications

Serum Haptoglobin in Cases of Ischemic Heart Diseases

Serum Haptoglobin in Cases of Ischemic Heart Diseases

Evaluation of Carbamazepine and Carbamazepine‐Epoxide Protein Binding in Patients Undergoing Epilepsy Surgery

Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis.

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