Immunochemical Composition of Cryoglobulins Generated in Stroke

Manukyan, Levon; Boyajyan, Anna; Arakelyan, Arsen; Ayvazyan, Violetta; Arakelova, Elina; Sim, Robert B.; Grigoryan, George

doi:10.1007/s10875-008-9257-5

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…18 Lipoprotein X has been also detected in the blood of patients with acute viral hepatitis, 19 drug-induced cholestatic hepatitis 20 and in patients with ischaemic stroke. 21…”

Section: Lipoprotein Xmentioning

confidence: 99%

“…18 Lipoprotein X has been also detected in the blood of patients with acute viral hepatitis, 19 drug-induced cholestatic hepatitis 20 and in patients with ischaemic stroke. 21 The effect of hypercholesterolemia and hypertriglyceridaemia on the measurements of electrolytes has been well investigated. 22 Similarly, the presence of very high levels of lipoprotein X has been shown to be a rare cause of pseudohyponatraemia, 23 that we also noticed in our patient at the acute presentation.…”

Section: Lipoprotein Xmentioning

confidence: 99%

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Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia

et al. 2013

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Hypertriglyceridaemia is an established cause of acute pancreatitis and responds to insulin therapy in addition to lipid lowering medication. We report a case of severe hypertriglycaeridemia of 149 mmol/L in a 36-year-old man with type 2 diabetes who presented to the surgical ward with abdominal pain due to pancreatitis and developed acute cholestasis, jaundice and eruptive xanthomata. His triglycerides improved to 3.8 mmol/L with sliding scale insulin within two weeks of in-hospital stay. However, his total cholesterol remained raised at 23.7 mmol/L. The lipoprotein electrophoresis confirmed the presence of lipoprotein X associated with bile obstruction, which contributed to an increase in total cholesterol. The total cholesterol normalized on improvement of his cholestasis. 2013; 50: 173-175. DOI: 10.1258 50: 173-175. DOI: 10. /acb.2012 Case A 36-year-old Caucasian man was admitted to the surgical ward in this hospital with the third episode of acute on chronic pancreatitis in the previous six years. Two earlier such events were followed by recurrent complex pancreatic surgery. He also had a cholecystectomy performed for gallstones. The patient had an eight-year history of type 2 diabetes, poorly controlled by treatment with metformin and insulin (glycosylated haemoglobin [HbA1c] 12.5%, 113 mmol/mol) and a history of non-alcoholic steatohepatitis. Prior to the admission in order to control his lipid profile he had been on atorvastatin tablets for months but had run out of his medications and was off them for approximately eight weeks. He has never smoked and ceased drinking alcohol after the first episode of pancreatitis in 2005. His past history included self-administration of steroid and testosterone injections in the year 2000 for building muscle strength before participating in heavy-lifting competitions. Ann Clin Biochem

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“…18 Lipoprotein X has been also detected in the blood of patients with acute viral hepatitis, 19 drug-induced cholestatic hepatitis 20 and in patients with ischaemic stroke. 21…”

Section: Lipoprotein Xmentioning

confidence: 99%

Section: Lipoprotein Xmentioning

confidence: 99%

Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia

et al. 2013

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Role of complement in the pathomechanism of atherosclerotic vascular diseases

Varga

Füst

Prohászka

2009

Molecular Immunology

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Anomalous lipoprotein-X in type 2 diabetes mellitus

Овсепян¹,

Ébragimzade²,

Габриелян³

et al. 2012

Probl Endokrinol (Mosk)

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Type 2 diabetes mellitus (DM2) is the most common form of diabetes characterized by the disturbances of carbohydrate, protein, and lipid metabolism including dyslipidemia and elevation of the low-density lipoprotein (LDLP) levels. Lipoprotein-X (LP-X) represents an anomalous subclass of LDLP a distinctive feature of which is the high content of phospholipids and non-esterified cholesterol coupled with the low level of cholesterol ethers, triglycerides, and proteins. LP-X was detected in the blood of the patients with various diseases of the liver and biliary ducts associated with cholestasis. The results of our previous investigations suggest the presence of LP-X in the blood of the patients with familial Mediterranean fever and ischemic stroke complicated by concomitant diabetes mellitus. The objective of the present work was to elucidate whether LP-X actually occurs in the blood of the patients presenting with type 2 diabetes mellitus. We used the method of polyanionic precipitation of LDLP preliminarily separated by agar gel electrophoresis. The study has demonstrated for the first time the presence of LP-X in the blood of the patients with type 2 diabetes mellitus. Its possible pathogenetic role and mechanisms of LP-X generation in DM2 are discussed.

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Immunochemical Composition of Cryoglobulins Generated in Stroke

Abstract: We suggest that cryoglobulins are involved in post-ischemic inflammatory response through activation of the complement cascade and cytokines production.

Cited by 3 publications

References 37 publications

Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia

Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia

Role of complement in the pathomechanism of atherosclerotic vascular diseases

Anomalous lipoprotein-X in type 2 diabetes mellitus

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