Immunobiotic Strains Modulate Toll-Like Receptor 3 Agonist Induced Innate Antiviral Immune Response in Human Intestinal Epithelial Cells by Modulating IFN Regulatory Factor 3 and NF-κB Signaling

Kanmani, Paulraj; Kim, Hojun

doi:10.3389/fimmu.2019.01536

Cited by 13 publications

(16 citation statements)

References 58 publications

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“…In the intestinal human colon cell line (HCT116), regulation of Poly I/C response by Lactiplantibacillus plantarum subsp. plantarum DU1, Latilactobacillus sakei DU2, and Weissella cibaria DU1 was examined [ 67 ]. These strains modified Poly I/C-induced expression of cytokines and antiviral genes by upregulating IFN-β, TLR3, and RIG-I while dampening the inflammatory response.…”

Section: Probiotics and Immune Modulation In Viral Respiratory Infmentioning

confidence: 99%

“…These strains modified Poly I/C-induced expression of cytokines and antiviral genes by upregulating IFN-β, TLR3, and RIG-I while dampening the inflammatory response. Moreover, the probiotic strains induced IFN-α, IFN-β, and IL-10 and reduced the expression of inflammatory cytokines IL-1β and TNF-α in human monocytic THP-1 macrophages [ 67 ]. In addition to the pro-inflammatory and antiviral gene activation described above, also direct interactions of viruses and probiotic bacteria have been demonstrated between porcine influenza A virus and Enterococcus faecium in vitro [ 68 ].…”

Section: Probiotics and Immune Modulation In Viral Respiratory Infmentioning

confidence: 99%

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Role of Probiotics in Stimulating the Immune System in Viral Respiratory Tract Infections: A Narrative Review

2020

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Viral respiratory tract infection (RTI) is the most frequent cause of infectious illnesses including the common cold. Pharmacological solutions for treating or preventing viral RTIs are so far limited and thus several self-care products are available in the market. Some dietary supplements such as probiotics have been shown to modulate immune system function and their role in reducing the risk and the course of RTIs has been investigated extensively within the past decade. However, the mechanism of action and the efficacy of probiotics against viral RTIs remains unclear. We searched PubMed, Google Scholar, and Web of Knowledge for pre-clinical and clinical studies investigating the effect of probiotics on respiratory virus infections, immune response, and the course of upper and lower respiratory tract illness. The literature summarized in this narrative review points out that specific probiotic strains seem effective in pre-clinical models, through stimulating the immune system and inhibiting viral replication. Clinical studies indicate variable efficacy on upper respiratory illnesses and lack proof of diagnosed viral infections. However, meta-analyses of clinical studies indicate that probiotics could be beneficial in upper respiratory illnesses without specific etiology. Further studies aiming at discovering the mechanisms of action of probiotics and clinical efficacy are warranted.

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Section: Probiotics and Immune Modulation In Viral Respiratory Infmentioning

confidence: 99%

Section: Probiotics and Immune Modulation In Viral Respiratory Infmentioning

confidence: 99%

Role of Probiotics in Stimulating the Immune System in Viral Respiratory Tract Infections: A Narrative Review

2020

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“…On the other hand, probiotics may exert immunomodulatory effects in viral and bacterial infections through modulation of cytokine levels [ 21 , 22 ]. Particularly, DR7 reduced pro-inflammatory cytokine IFN-γ and increased anti-inflammatory cytokines IL-10 in plasma, and targeted the tryptophan-5HTT-kynurenine pathway [ 12 ] via downregulation of IDO and TDO [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Lactobacilli Probiotic on Reducing Duration of URTI and Fever, and Use of URTI-Associated Medicine: A Re-Analysis of a Randomized, Placebo-Controlled Study

2021

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We previously reported on the effects of Lactoplantibacillus plantarum DR7 on reducing Upper Respiratory Tract Infections (URTI) symptoms’ score and frequency in 109 adults upon a 12-week consumption at 109 colony-forming units (CFU)/day, but several limitations were detected in the publication. Thus, the present study re-analyzed some data with the aim to address some of these weaknesses, and presents new data on duration of URTI and consumption of URTI-associated medication, as compared to the placebo. Our re-analyses found probiotic administration significantly reduced the proportion of patient days of URTI and of fever (all p < 0.05). Recent history of URTI was a prevalent co-factor in affecting duration of URTI symptoms and fever, while other demographic and clinical factors had no influence. Exploratory analyses suggested probiotic had an earlier benefit in patients without a recent history of URTI compared to those with a recent history of URTI. Therefore, recent history of infections could have a modulatory effect on probiotic efficacy. Average number of months with reported use of URTI-related medication was 3.4-times lower in the probiotic group as compared to placebo (p = 0.016) during the intervention. Taken together, our present new data further support previous findings that DR7 probiotic had a beneficial effect on URTI.

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“…This thus increases the number of macrophages and dendritic cells in the intestinal lamina propria, with greater production of TNF-a and IFN-g that favor a state of tolerance with increased immunoglobulin (Ig)Aþ cells. [111][112][113] Cytokines produced locally in the intestine can influence the activity of immune cells at distant sites, including the bronchi, inducing the activation of regulatory T cells that release IL-10. Additionally, probiotics strengthen the intestinal barrier by increasing mucin and tightjunction proteins, as well as goblet and Paneth cells that produce bactericidal substances.…”

Section: Probioticsmentioning

confidence: 99%

“…Additionally, probiotics strengthen the intestinal barrier by increasing mucin and tightjunction proteins, as well as goblet and Paneth cells that produce bactericidal substances. [111][112][113] Modulation of the gut microbiota is a mechanism by which probiotics maintain the balance and suppression of harmful pathogens. The viability of probiotics is crucial for the interaction with epithelial cells and macrophages, mainly favoring the innate immune response, with increased microbicidal activity of peritoneal and splenic macrophages.…”

Section: Probioticsmentioning

confidence: 99%

Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions

Larenas‐Linnemann¹,

Rodríguez-Pérez²,

Arias-Cruz³

et al. 2020

World Allergy Organization Journal

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Introduction In the light of the current COVID-19 pandemic, during which the world is confronted with a new, highly contagious virus that suppresses innate immunity as one of its initial virulence mechanisms, thus escaping from the first-line human defense mechanisms, enhancing innate immunity seems a good preventive strategy. Methods Without the intention to write an official systematic review, but more to give an overview of possible strategies, in this review article we discuss several interventions that might stimulate innate immunity and thus our defense against (viral) respiratory tract infections. Some of these interventions can also stimulate the adaptive T- and B-cell responses, but our main focus is on the innate part of immunity. We divide the reviewed interventions in: 1) lifestyle related (exercise, >7 hours sleep, forest walking, meditation/mindfulness, vitamin supplementation); 2) Non-specific immune stimulants (letting fever advance, bacterial vaccines, probiotics, dialyzable leukocyte extract, pidotimod) and 3) specific vaccines with heterologous effect (BCG vaccine, mumps-measles-rubeola vaccine, i.e.). Results For each of these interventions we briefly comment on their definition, possible mechanisms and evidence of clinical efficacy or lack of it, especially focusing on respiratory tract infections, viral infections and eventually a reduced mortality in severe respiratory infections in the intensive care unit. At the end a summary table demonstrates the best trials supporting (or not) clinical evidence. Conclusion Several interventions have some degree of evidence for enhancing the innate immune response and thus conveying possible benefit, but specific trials in COVID-19 should be conducted to support solid recommendations.

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Immunobiotic Strains Modulate Toll-Like Receptor 3 Agonist Induced Innate Antiviral Immune Response in Human Intestinal Epithelial Cells by Modulating IFN Regulatory Factor 3 and NF-κB Signaling

Cited by 13 publications

References 58 publications

Role of Probiotics in Stimulating the Immune System in Viral Respiratory Tract Infections: A Narrative Review

Role of Probiotics in Stimulating the Immune System in Viral Respiratory Tract Infections: A Narrative Review

Effects of a Lactobacilli Probiotic on Reducing Duration of URTI and Fever, and Use of URTI-Associated Medicine: A Re-Analysis of a Randomized, Placebo-Controlled Study

Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions

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