Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection

Chiba, Eriko; Tomosada, Yohsuke; Vizoso-Pinto, María Guadalupe; Salva, Susana; Takahashi, Takuya; Tsukida, Kohichiro; Kitazawa, Haruki; Alvarez, Susana; Villena, Julio

doi:10.1016/j.intimp.2013.06.024

Cited by 76 publications

(132 citation statements)

References 38 publications

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“…Based on previous results using the immunobiotic strain L. rhamnosus CRL1505 for enhancing antiviral immunity against RSV and modulating inflammation [21,28], we explored the effectiveness of this strain (alive or heatkilled) to reduce the influenza burden of disease. IFV-infected mice receiving Lr1505 or HK-Lr1505 showed a milder disease course than non-treated mice, and presented a significantly higher survival rate.…”

Section: Discussionmentioning

confidence: 99%

Nasal priming with immunobiotic Lactobacillus rhamnosus modulates inflammation–coagulation interactions and reduces influenza virus-associated pulmonary damage

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Nasal priming with immunobiotic Lactobacillus rhamnosus modulates inflammation–coagulation interactions and reduces influenza virus-associated pulmonary damage

et al. 2015

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“…Therefore, we next examined whether oral administration of L. rhamnosus CRL1505 was able to reduce the susceptibility of infant mice to RSV infection. We demonstrated that oral administration of L. rhamnosus CRL1505 contributed to a significant decrease of RSV titers and lung tissue damage after the challenge with the respiratory pathogen (64). The protective effect achieved by the immunobiotic strain was related to its ability to modulate the respiratory anti-viral response.…”

Section: Distal Modulation Of Respiratory Anti-viral Immunity By L Rmentioning

confidence: 97%

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

Kitazawa

Villena

2014

Front. Immunol.

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Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illness in infants and young children. Host immune response is implicated in both protective and immunopathological mechanisms during RSV infection. Activation of Toll-like receptor (TLR)-3 in innate immune cells by RSV can induce airway inflammation, protective immune response, and pulmonary immunopathology. A clear understanding of RSV–host interaction is important for the development of novel and effective therapeutic strategies. Several studies have centered on whether probiotic microorganisms with the capacity to stimulate the immune system (immunobiotics) might sufficiently stimulate the common mucosal immune system to improve defenses in the respiratory tract. In this regard, it was demonstrated that some orally administered immunobiotics do have the ability to stimulate respiratory immunity and increase resistance to viral infections. Moreover, during the last decade scientists have significantly advanced in the knowledge of the cellular and molecular mechanisms involved in the protective effect of immunobiotics in the respiratory tract. This review examines the most recent advances dealing with the use of immunobiotic bacteria to improve resistance against viral respiratory infections. More specifically, the article discuss the mechanisms involved in the capacity of the immunobiotic strain Lactobacillus rhamnosus CRL1505 to modulate the TLR3-mediated immune response in the respiratory tract and to increase the resistance to RSV infection. In addition, we review the role of interferon (IFN)-γ and interleukin (IL)-10 in the immunoregulatory effect of the CRL1505 strain that has been successfully used for reducing incidence and morbidity of viral airways infections in children.

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“…These successful preclinical and clinical trials highlight the potential of LAB probiotics as preventive and therapeutic agents in RVI. Protective effect achieved by strain CRL1505 was related to its capacity to modulate respiratory antiviral immune response by secretion of IFN-c and IL (Salva et al, 2013). In direct line, Chiba et al 2013, showed that oral administration of L. rhamnosus CRL1505 to of BALB/cmice permitted a protective effect by modulating pulmonary innate immune microenvironment.…”

Section: Antiviral Activity Of Labmentioning

confidence: 95%

“…Protective effect achieved by strain CRL1505 was related to its capacity to modulate respiratory antiviral immune response by secretion of IFN-c and IL (Salva et al, 2013). In direct line, Chiba et al 2013, showed that oral administration of L. rhamnosus CRL1505 to of BALB/cmice permitted a protective effect by modulating pulmonary innate immune microenvironment. The use of LAB as antiviral agents is relevant for agriculture poultry industry and medical applications for treatment of various viral infections.…”

Section: Antiviral Activity Of Labmentioning

confidence: 95%

Overview of Anticancer activity of Lactic Acid bacteria

Delesa¹

2017

Int. J. Adv. Res. Biol. Sci.

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Cancer vestiges one of the leading causes of deaths worldwide despite its advances treatment and detection and the conventional chemotherapeutic agents used for the treatment of cancer have non-specific toxicity toward normal body cells that cause various side effects. In addition, cancer cells are known to develop chemotherapy resistance in due course of treatment, so, it's difficult and not easy to treat cancer using normal antiviral drugs. Thus, the demand for novel anti-cancer agents is increasing important to develop novel biological control approach. Some research reports have shown the therapeutic potential of LAB against various types of cancer cell lines. This makes them promising candidates for further investigation and clinical treatments. While a myriad of healthful effects have been attributed to lactic acid bacteria (LAB), perhaps the most controversial remains that of anticancer activity. The precise mechanisms by which LAB may inhibit any cancer are currently unknown. However, such mechanisms might include: alteration of the metabolic activities of intestinal microflora; alteration of physico-chemical conditions in the colon and gut; binding and degrading potential carcinogens; quantitative and/or qualitative alterations in the intestinal microflora incriminated in producing putative carcinogen(s) and promoters; production of antitumourigenic or antimutagenic compounds; enhancing the host's immune response; and effects on physiology of the host. In this review article, we present the overview of anticancer activity of the lactic acid bacteria.

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Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection

Cited by 76 publications

References 38 publications

Nasal priming with immunobiotic Lactobacillus rhamnosus modulates inflammation–coagulation interactions and reduces influenza virus-associated pulmonary damage

Nasal priming with immunobiotic Lactobacillus rhamnosus modulates inflammation–coagulation interactions and reduces influenza virus-associated pulmonary damage

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

Overview of Anticancer activity of Lactic Acid bacteria

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