Immunobiochemical assay for determination of nuclear steroid receptors

Vering, A.; Hg, Schnürch; Lennartz, L.

doi:10.1016/0090-8258(92)90275-n

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Gynecologic Oncology

1992

DOI: 10.1016/0090-8258(92)90275-n

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Immunobiochemical assay for determination of nuclear steroid receptors

A. Vering

Schnürch Hg

L. Lennartz

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1993

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Immuno-biochemical assay for determination of nuclear steroid receptors during tamoxifen therapy

Vering

Vockel

Stegmüller

1993

J Cancer Res Clin Oncol

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The exact knowledge of hormone receptor status is critical for therapeutic strategies in hormone-dependent tumors. The influence of tamoxifen on estrogen receptor concentration has to be taken into account when evaluating results in tamoxifen-treated patients. We studied the receptor modulation of tumors xenotransplanted into nude mice (one breast and one endometrial carcinoma) after injection of 50 micrograms tamoxifen/mouse. To differentiate between unoccupied and occupied receptors, determinations were done by an enzyme immunoassay for the estrogen receptor under low- and high-salt extraction. With low-salt extraction we found a temporary decrease of the estrogen receptor concentration within the first hours after tamoxifen treatment. This decrease lasted for several days before recovery to pretreatment levels occurred. The hormone-receptor complexes, tightly bound to acceptor sites of the DNA, increased more than 15 times within 24 h. These values remained at increased levels for 2-7 days, after which a decrease to initial level was observed.

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Immuno-biochemical assay for determination of nuclear steroid receptors during tamoxifen therapy

Vering

Vockel

Stegmüller

1993

J Cancer Res Clin Oncol

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Immunobiochemical assay for determination of nuclear steroid receptors

Cited by 1 publication

References 15 publications

Immuno-biochemical assay for determination of nuclear steroid receptors during tamoxifen therapy

Immuno-biochemical assay for determination of nuclear steroid receptors during tamoxifen therapy

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