Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein

Moutachakkir, Mariame; Hanchi, Asma Lamrani; Baraou, Azzedine; Boukhira, Abderrahman; Chellak, Saliha

doi:10.1684/abc.2017.1232

Cited by 79 publications

(73 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that these indicators have directive effects on the infection and condition judgment of other viral diseases (Vollmer et al, 2016;Moutachakkir et al, 2017;Piedra et al, 2017;Yuan et al, 2015). This study also reveals the relationship between these indicators and viral load among COVID-19 patients and provides clues for the prevention and control of the disease.…”

Section: Discussionsupporting

confidence: 53%

Association of viral load with serum biomakers among COVID-19 cases

Shi

Zhu

et al. 2020

Virology

View full text Add to dashboard Cite

Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. We measured and compared viral loads of SARS-CoV-2 from pharyngeal swab, IgM anti-SARS-CoV-2, CRP and SAA from serum of 114 COVID-19 patients on admission. Positive rates of IgM anti-SARS-CoV-2, CRP and SAA were 80.7%, 36% and 75.4% respectively. Among IgMpositive patients, viral loads showed different trends among cases with different severity, While viral loads of IgM-negative patients tended to increase along with the time after onset. As the worsening of severity, the positive rates of CRP and SAA also showed trends of increase. Different CRP/SAA type showed associations with viral loads in patients in different severity and different time after onset. Combination of the IgM and CRP/SAA with time after onset and severity may give suggestions on the viral load and condition judgment of COVID-19 patients. Dear Editor I'm sending a original article entitled "Association of Viral Load With Serum Biomakers Among COVID-19 Cases", which we would like to submit for publication in VIROLOGY. No part of this article has been published or submitted elsewhere, and no conflict of interest exists in the submission of this manuscript. In this article, we investigated the natural fluctuation of viral load among COVID-19 cases before antiviral therapy and the serum biomarkers associated with it. We found the viral loads had different trends and peaked at different time among COVID-19 patients. Combining the detection of IgM anti-SARS-CoV-2, C-reactive protein and Serum amyloid A may give suggestions on the viral load and condition judgment of COVID-19 patients at different stages of illness. The changes of viral load among patients of different clinical severity and different time after onset also can be tracked and used to inform public health policies to prevent the spread of SARS-CoV-2. The findings may facilitate the prevention and control of COVID-19.

show abstract

Section: Discussionsupporting

confidence: 53%

Association of viral load with serum biomakers among COVID-19 cases

Shi

Zhu

et al. 2020

Virology

View full text Add to dashboard Cite

show abstract

“…From animal studies to the clinic (Review) a more sensitive method for detecting atherosclerotic inflammation. The reason for this is that in order to detect CRP with high sensitivity, the detection limit needs to be minimized as far as possible (13)(14)(15). The US Centers for Disease Control and Prevention has previously issued a statement that classifies hs-CRP levels and risk categories as follows: low risk <1.0 mg/l; intermediate risk 1.0-3.0 mg/l; and high risk >3.0 mg/l (16,17).…”

Section: C-reactive Protein and Cardiovascular Diseasementioning

confidence: 99%

C‑reactive protein and cardiovascular disease: From animal studies to the clinic (Review)

Liu

2020

Exp Ther Med

View full text Add to dashboard Cite

C-reactive protein (CRP) and cardiovascular disease (CVD) have long been important research topics. CRP is an acute phase protein, while CVD is an inflammatory condition. The association between CRP and CVD remains controversial and has been attracting increasing attention. Traditionally, the main marker of CVD is considered to be low-density lipoprotein cholesterol. However, due to its unique characteristics, CRP may represent a novel marker or a new therapeutic target for CVD. Clinical studies have demonstrated that CRP is a predictor of CVD, but whether it is directly involved in the development and progression of CVD has yet to be fully elucidated. Recent clinical studies have demonstrated that lowering plasma CRP levels may reduce the incidence of CVD. The aim of the present review was to investigate the association between CRP and CVD, particularly atherosclerosis, from laboratory animal studies to clinical research.

show abstract

“…Genotypes reflect how MBL levels behave most of the time and it is a more constant variable. The second interesting observation is that MBL genotypes show an inverse relationship of MBL production, not only with IMT but also with serum CRP levels, already recognized to be linked to the atherosclerotic process [ 26 ]. Lower MBL producers had higher IMT and higher CRP serum levels.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk and mannose binding lectin in patients with rheumatoid arthritis from southern Brazil

Kahlow

Nisihara

Petisco

et al. 2018

IJC Heart & Vasculature

View full text Add to dashboard Cite

BackgroundMannose binding lectin (MBL) appears to be involved in susceptibility to rheumatoid arthritis (RA), in the inflammatory process and in the genesis of atherosclerotic disease.ObjectiveTo study the association of MBL serum levels and its genotypic variation with carotid arteries intimal thickness (IMT) in RA patients from Southern Brazil.MethodsMBL serum levels, MBL2 genotyping and IMT were investigated in 90 RA patients along with their demographic, clinical and laboratory profile. MBL levels and MBL2 genotyping were evaluated in 90 healthy controls.ResultsA significant lower MBL serum concentration was observed in patients with RA in relation to controls (528 ng/mL vs 937.5 ng/mL, p = 0.05, respectively). The median IMT in RA patients was 0.59 mm (0.51 to 0.85 mm). There was no correlation between levels of MBL with disease activity, erythrocyte sedimentation rate, autoantibodies presence or IMT (p = NS). A weak and negative correlation was found between MBL and CRP levels (Rho = −0.24; p = 0.02;). The MBL2 variant at codon 54 (variant B) and HYPA haplotype were the most frequently observed in the RA sample (67.5% and 31.7%). MBL2 wild type (A/A) were associated with lower IMT when compared with heterozygotes (A/O; p = 0.04) and low producers (O/O; p = 0.05). In addition, high producers genotypes had lower levels of CRP when compared with medium (p = 0.04) or with low producers (p = 0.05).ConclusionRA patients had lower MBL levels than controls. MBL were negatively associated with CRP serum levels; low MBL genotypes producers increased thickness of the IMT than high producers.

show abstract

Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein

Cited by 79 publications

References 0 publications

Association of viral load with serum biomakers among COVID-19 cases

Association of viral load with serum biomakers among COVID-19 cases

C‑reactive protein and cardiovascular disease: From animal studies to the clinic (Review)

Cardiovascular risk and mannose binding lectin in patients with rheumatoid arthritis from southern Brazil

Contact Info

Product

Resources

About