Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis

Naber, Kurt G.; Cho, Yong Hyun; Matsumoto, Tetsuro; Schaeffer, Anthony J.

doi:10.1016/j.ijantimicag.2008.08.011

Cited by 141 publications

(113 citation statements)

References 44 publications

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“…8 Immunoactive prophylaxis of recurrent UTIs with lyophilized lysate of E. coli (OM-89) has been shown to be more effective than placebo in randomized trials with a good safety profile. 11,12 It is recommended for RUTI prevention by the 2015 European Association of Urology guidelines and the 2015 Febrasgo Manual of Urogynecology. 6,7 The accessibility of clinically proven probiotics for UTI prophylaxis is currently not universal.…”

Section: Non-antimicrobial Methods Should Be Considered For Ruti Prevmentioning

confidence: 99%

Recurrent Urinary Tract Infection in the Gynecologic Practice: Time for Reviewing Concepts and Management

Filho

Contreras

Haddad

2016

Rev Bras Ginecol Obstet

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Section: Non-antimicrobial Methods Should Be Considered For Ruti Prevmentioning

confidence: 99%

Recurrent Urinary Tract Infection in the Gynecologic Practice: Time for Reviewing Concepts and Management

Filho

Contreras

Haddad

2016

Rev Bras Ginecol Obstet

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“…Naber et al [49] , indicating that it was more effective than placebo [50,51]. In a large-scale controlled study conducted subsequently in which 453 women took oral Uro-Vaxom Ⓡ for a year, the occurrence of UTI was reduced by 34% [51].…”

Section: Immunostimulationmentioning

confidence: 99%

“…SolcoUrovac Ⓡ is a vaginal tablet containing 10 types of urologic microbiological strains. It is reported to have a prophylactic effect against moderate UTI but the effect is limited to the period during which the drug is taken [49,54]. Recent advances in technology have led to greater understanding of the effects of E. coli on UTI, and it is anticipated that a longer-lasting and more specific recurrent UTI-enhancing agent or vaccine could be developed.…”

Section: Immunostimulationmentioning

confidence: 99%

2017 Guidelines of The Korean Association of Urogenital Tract Infection and Inflammation: Recurrent Urinary Tract Infection

Lee

Choe

et al. 2017

Urogenit Tract Infect

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Recurrent infection after an acute urinary tract infection (UTI) episode is common in adult women. It is onerous to both the patient and the physician to treat frequent recurrent UTI. Every time when UTI recurs, patients experience lower urinary tract symptoms, fatigue, and limitation in everyday life, while the physician has difficulty in counseling patients with a disease entity whose pathophysiology is less known. Currently, prophylactic treatment for recurrent UTI is limited, is ineffective in most cases, and sometimes accompanies unexpected side effects. In this guideline, we aimed to establish feasible and effective recommendations for the treatment of recurrent UTI in healthy adult women.

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“…Posle gotovo dvadeset godina od poč-etka primene vakcina u profilaksi infekcija mokraćnih puteva urađena je meta-analiza objavljenih studija i zaključeno da, osim za vakcinu OM-89/Uro-Vaxom, nedostaju studije sa rezultatima faze III kliničkog ispitivanja za većinu preparata pa da se ne može izvesti definitivan zaključak o njihovoj efikasnosti [42].…”

Section: Imunoaktivna Profilaksa (Vakcine)unclassified

Rekurentne infekcije mokraćnih puteva: antimikrobna i imunoaktivna profilaksa

Djukanović

2015

Biomedicinska istraž.

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Kratak sadržajInfekcije mokraćnih puteva su najčešće bakterijske vanbolničke infekcije od kojih češće oboljevaju žene, а оko 20% do 35% žena nakon prve ima ponovnu infekciju mokraćnih puteva. Rekurentnom infekcijom mokraćnih puteva se smatra infekcija koje se ponavljala najmanje tri puta u prethodnoj godini. Faktori rizika za rekurentne infekcije mokraćnih puteva su menopauza, pozitivna porodična anamneza o urinarnim infekcijama, seksualna aktivnost, promena seksualnog partnera, korišćenje spermicida, kao i deficit lokalnog imuniteta. U svim slučajevima u kojima se dokaže da se radi o renfekcijama neophodno je da se primene mere profilakse.Profilaksa se može sprovoditi antimikrobnim lekovima i drugim metodama i sredstvima. Antimikrobni lekovi se primenjuju kontinuirano ili postkoitalno u trajanju od godinu dana, a kod motivisanih bolesnica može se primeniti samozapočinjanje antimikrobne terapije pri recidivu infekcije.Ostale ne-antimikrobne mere profilakse obuhvataju vaginalnu primenu estrogena kod žena u postmenopauzi koje nisu na hormonskoj supstitucionoj terapiji estrogenima, vaginalnu primenu laktobacila, imunoprofilaksu, kao i korišćenje produkata brusnice, izbegavanje primene spermicida, izbegavanje kupanja u kadi i penama. Imunoaktivna profilaksa (vakcine) rekurentnih infekcija mokraćnih puteva je uvedena sa ciljem da se stimuliše lokalni imunski odgovor protiv uropatogenih bakterija. Vakcine su sastavljene ili od umrtvljenih uropatogenih bakterija ili od liofilizovanih proteina membrane uropatogenih bakterija. Da bi se prevazišla velika antigenska varijabilnost uropatogenih bakterija i njihovi različiti mehanizmi virulencije, brojna eksprimentalna istraživanja su usmerena ka proizvodnji vakcina protiv pojedinih komponenti virulencije bakterija, kao i vakcina protiv genetski modifikovanih sojeva bakterija.Postojanje brojnih mera profilakse govori o njihovoj nedovoljnoj efikasnosti, a kombinovano i uporno sprovođenje proverenih mera predstavlja, za sada, jedini način za sprečavanje recidiva infekcije.Ključne reči: rekurentne infekcije mokraćnih puteva, profilaksa, vakcine UvodInfekcija mokraćnih puteva je naziv koji označava prodor mikroorganizama u prethodno sterilan mokraćni sistem, njihovo razmnožavanje i održavanje koje izaziva zapaljenje kao odgovor domaćina. One predstavljaju ne samo ozbiljan zdravstveni nego

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Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis

Cited by 141 publications

References 44 publications

Recurrent Urinary Tract Infection in the Gynecologic Practice: Time for Reviewing Concepts and Management

Recurrent Urinary Tract Infection in the Gynecologic Practice: Time for Reviewing Concepts and Management

2017 Guidelines of The Korean Association of Urogenital Tract Infection and Inflammation: Recurrent Urinary Tract Infection

Rekurentne infekcije mokraćnih puteva: antimikrobna i imunoaktivna profilaksa

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