Immunoactive products of human placenta IV. Immunoregulatory factors obtained from cultures of human placenta inhibit in vivo local and systemic allogeneic and graft versus-host reactions in mice

Pregnancy specific glycoprotein 18 induces IL-10 expression in murine macrophages

“…Hormones have been shown to modulate macrophage function and to induce the production of Th2 cytokines by T cells [18][19][20]. Other immunomodulators have also been reported to contribute to a successful pregnancy [21,22].…”

Effects of 1,25-Dihydroxyvitamin D₃ on in vitro Lymphocyte Reactions: Arguments for a Role at the Maternofetal Interface

“…Moreover a synergistic interac tion between PGE2 and calcitriol in the inhibition of mitogenic stimulation of human lymphocytes has re cently been demonstrated [23], NK cells have been reported to exhibit functional activity in NKH-1-enriched first-trimester human decid ua cells [24], However, although human fetal fibroblasts and probably trophoblasts as well possess the target structure necessary for NK-mediated toxicity, locally produced NK suppressor factor may regulate decidual activity in vivo. Here, we found that calcitriol reduced non-MHC-restricted cytotoxicity; it potentiated the ef fect of placental supernatant [25] which in this system was earlier shown to inhibit NK cytotoxicity in mice [26] and in humans [27], NK cells are currently considered to be a subpopulation of naturally activated lymphocytes which might constitutively express the vitamin D recep tors that mediate the biological effects of 1,25(OH)2D3. An overnight preincubation of PBLs with calcitriol was necessary for the latter to inhibit NK activity, and as previously described [28], calcitriol was thought to in hibit the generation of NK-like activity without directly affecting NK effector activity.…”

Biological Activity of the Suppressor Cells Inducer Factor Secreted by the Jeg‐3 Choriocarcinoma Cell Line

“…BA11 is a protective monoclonal antibody against the R80k antigen on trophoblast surface, and human placenta supernatant (HPS) was obtained from trophoblast cultures from healthy human term placentae. 9,11 Animals were killed at day 12.5 and resorbed fetuses were counted macroscopically. The total number of fetuses (n) and pregnant mice (m) is indicated on the top of each bar.…”