Immuno-protective role of biologically synthesized dietary selenium nanoparticles against multiple stressors in Pangasinodon hypophthalmus

Kumar, Neeraj; Krishnani, Kishore Kumar; Gupta, Sanjay Kumar; Sharma, Rupam; Baitha, Raju; Singh, Dilip K.; Singh, Narendra Pratap

doi:10.1016/j.fsi.2018.04.051

Cited by 68 publications

(29 citation statements)

References 65 publications

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“…The highest mortality was observed in the multiple stressors group (arsenic and temperature) and the lowest was observed in the supplemental group with dietary Se-NPs and RF. Lower mortality demonstrated in the group supplemented with dietary Se-NPs is in accordance with our previous report 34 . The protective effect of Se-NPs against pathogenic infection might be associated due to its role in immunostimulation in fish as reported in our previous study 33 .…”

Section: Discussionsupporting

confidence: 93%

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Mitigation potential of selenium nanoparticles and riboflavin against arsenic and elevated temperature stress in Pangasianodon hypophthalmus

Kumar

Gupta

Chandan

et al. 2020

Sci Rep

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Climate change impact has disturbed the rainfall pattern worsening the problems of water availability in the aquatic ecosystem of India and other parts of the world. Arsenic pollution, mainly through excessive use of groundwater and other anthropogenic activities, is aggravating in many parts of the world, particularly in South Asia. We evaluated the efficacy of selenium nanoparticles (Se-NPs) and riboflavin (RF) to ameliorate the adverse impacts of elevated temperature and arsenic pollution on growth, anti-oxidative status and immuno-modulation in Pangasianodon hypophthalmus. Se-NPs were synthesized using fish gill employing green synthesis method. Four diets i.e., Se-NPs (0 mg kg−1) + RF (0 mg kg−1); Se-NPs (0.5 mg kg−1) + RF (5 mg kg−1); Se-NPs (0.5 mg kg−1) + RF (10 mg kg−1); and Se-NPs (0.5 mg kg−1) + RF (15 mg kg−1) were given in triplicate in a completely randomized block design. The fish were treated in arsenic (1/10th of LC50, 2.68 mg L−1) and high temperature (34 °C). Supplementation of the Se-NPs and RF in the diets significantly (p < 0.01) enhanced growth performance (weight gain, feed efficiency ratio, protein efficiency ratio, and specific growth rate), anti-oxidative status and immunity of the fish. Nitroblue tetrazolium (NBT), total immunoglobulin, myeloperoxidase and globulin enhanced (p < 0.01) with supplementation (Se-NPs + RF) whereas, albumin and albumin globulin (A:G) ratio (p < 0.01) reduced. Stress biomarkers such as lipid peroxidation in the liver, gill and kidney, blood glucose, heat shock protein 70 in gill and liver as well as serum cortisol reduced (p < 0.01) with supplementation of Se-NPs and RF, whereas, acetylcholine esterase and vitamin C level in both brain and muscle significantly enhanced (p < 0.01) in compared to control and stressors group (As + T) fed with control diet. The fish were treated with pathogenic bacteria after 90 days of experimental trial to observe cumulative mortality and relative survival for a week. The arsenic concentration in experimental water and bioaccumulation in fish tissues was also determined, which indicated that supplementation of Se-NPs and RF significantly reduced (p < 0.01) bioaccumulation. The study concluded that a combination of Se-NPs and RF has the potential to mitigate the stresses of high temperature and As pollution in P. hypophthalmus.

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Section: Discussionsupporting

confidence: 93%

“…The tissues were dissected out from morbid fish for confirmation of A. hydrophilla as a causative agent for death. This method was used in our previous works 22,34 .…”

Section: Blood Glucose the Determination Of Blood Glucose Was Determmentioning

confidence: 99%

Mitigation potential of selenium nanoparticles and riboflavin against arsenic and elevated temperature stress in Pangasianodon hypophthalmus

Kumar

Gupta

Chandan

et al. 2020

Sci Rep

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“…Similar to our results, Kumar et al. (2018) observed that iridescent sharks ( Pangasinodon hypophthalmus ) fed for 60 days with feed containing 1 mg Se nanoparticles/kg presented increases in weight gain and SGR, neither of which was observed using free Se. Similarly, Baldissera, Souza, Zeppenfeld, et al (2020) found that Nile tilapia fed 60‐days with 1.0 ml nerolidol‐loaded nanospheres presented significant increases in final mean weight and average daily weight gain compared with Nile tilapia fed with basal and free nerolidol‐supplemented diets.…”

Section: Discussionsupporting

confidence: 92%

Diphenyl diselenide‐loaded nanocapsules in silver catfish feed enhance growth, improve muscle antioxidant/oxidant status and increase selenium deposition: Advantages of nanotechnology for fish health

et al. 2020

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The aim of this study was to determine whether feed supplementation with nanoencapsulated Ph2Se2 would improve the growth performance of silver catfish and would maintain or improve the muscle antioxidant system. Final mean weight (p = .031), weight gain (p = .014) and specific growth rates (p = .045) were significantly higher in supplemented fish than in the control group. Muscle reactive oxygen species (p = .0001) levels were significantly lower in supplemented fish than in the control group. Also, muscle hydrogen peroxide (p = .0001) and lipid peroxidation (p = .0001) levels were significantly lower in supplemented fish than in the control group. Muscle antioxidant capacity against peroxyl radical (p = .00001) levels were significantly higher in fish supplemented with both Ph2Se2 forms (free or nanocapsules) than in the control group, while muscle superoxide dismutase (p = .001) and catalase (p = .0001) activities were significantly higher in supplemented fish than in the control group. Finally, selenium (Se) deposition (p = .00001) was significantly higher in the muscle of fish supplemented with free and nanoencapsulated forms compared with the control; and deposition levels were significantly higher in fish supplemented with Ph2Se2‐loaded in nanocapsules compared with the free form. Based on this evidence, Ph2Se2‐loaded in nanocapsules improves silver catfish performance and antioxidant/oxidant status. The greater content of Se (1.22 µg/g muscle) in the muscle of fish fed with dietary Ph2Se2‐loaded nanocapsules indicates that it may be considered a nutraceutical for fish.

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“…In Pangasius hypophthalmus fed with a diet incorporating 10 and 20 mg/kg ZnNPs and exposed to abiotic stress (sublethal dose of Pb 4ppm and temperature 34 °C), a considerably enhanced growth performance and improved immunological parameters (total protein, Alb, Glb, and Alb/Glb ratio) were observed, and reduced oxidative stress reflected in lower levels of blood glucose, cortisol, and HSP 70 suggested that the supplementation of dietary ZnNPs could alleviate abiotic stress in P. hypophthalmus [262]. In Mozambique tilapia ( Oreochromis mossambicus ) receiving a diet supplemented with 0.004% of Portunus pelagicus β-1,3-glucan binding protein based ZnO NPs, considerable increases in growth performance and in cellular and humoral immune responses were estimated.…”

Section: Veterinary Nanoscale Nutraceuticals and Dietary Supplementsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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Immuno-protective role of biologically synthesized dietary selenium nanoparticles against multiple stressors in Pangasinodon hypophthalmus

Cited by 68 publications

References 65 publications

Mitigation potential of selenium nanoparticles and riboflavin against arsenic and elevated temperature stress in Pangasianodon hypophthalmus

Mitigation potential of selenium nanoparticles and riboflavin against arsenic and elevated temperature stress in Pangasianodon hypophthalmus

Diphenyl diselenide‐loaded nanocapsules in silver catfish feed enhance growth, improve muscle antioxidant/oxidant status and increase selenium deposition: Advantages of nanotechnology for fish health

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

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