(Immuno)histological Analysis of Ewing Sarcoma

Marcilla, David; Machado, Isidro; Grünewald, Thomas G.P.; Llombart‐Bosch, Antonio; Álava, Enrique de

doi:10.1007/978-1-0716-1020-6_5

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…In gross examination, the cut surface of untreated EwS is grey-white, soft and frequently includes areas of hemorrhage and necrosis. Histologically, EwS has a solid pattern of growth, and is composed of monomorphic small cells with round nuclei [68]. The chromatin is finely stippled, and nucleoli are usually not apparent.…”

Section: Biopsy-the Holy Tissue Grailmentioning

confidence: 99%

“…CD99 is a cell surface glycoprotein and a very sensitive but poorly specific diagnostic marker for EwS [70,71]. Strong, diffuse membranous expression of CD99 is evident by immunohistochemistry in~95% of EwS [68]. However, CD99 expression occurs in many normal tissues and a wide variety of tumor types, including other SRCSs, and lymphoblastic lymphoma, and leukemia [71].…”

Section: Biopsy-the Holy Tissue Grailmentioning

confidence: 99%

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Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives

Zöllner

Amatruda

Bauer

et al. 2021

JCM

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131

114

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Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime example of the paradigms of a translocation-positive sarcoma: a genetically rather simple disease with a specific and neomorphic-potential therapeutic target, whose oncogenic role was irrefutably defined decades ago. This is a disease that by definition has micrometastatic disease at diagnosis and a dismal prognosis for patients with macrometastatic or recurrent disease. International collaborations have defined the current standard of care in prospective studies, delivering multiple cycles of systemic therapy combined with local treatment; both are associated with significant morbidity that may result in strong psychological and physical burden for survivors. Nevertheless, the combination of non-directed chemotherapeutics and ever-evolving local modalities nowadays achieve a realistic chance of cure for the majority of patients with Ewing sarcoma. In this review, we focus on the current standard of diagnosis and treatment while attempting to answer some of the most pressing questions in clinical practice. In addition, this review provides scientific answers to clinical phenomena and occasionally defines the resulting translational studies needed to overcome the hurdle of treatment-associated morbidities and, most importantly, non-survival.

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Section: Biopsy-the Holy Tissue Grailmentioning

confidence: 99%

Section: Biopsy-the Holy Tissue Grailmentioning

confidence: 99%

Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives

Zöllner

Amatruda

Bauer

et al. 2021

JCM

Self Cite

131

114

View full text Add to dashboard Cite

show abstract

“…Glycogen deposition results in cells being periodic acid-Schiff (PAS) stain positive cells. Cells with larger nuclei that are PAS negative characterize the atypical variant of Ewing sarcoma (9,10).…”

Section: Discussionmentioning

confidence: 99%

Misdiagnosis of Ewing’s sarcoma, A tragedy of a young female initially diagnosed with chronic osteomyelitis and ended with disarticulation (Case report)

Elbahri

Abdulkarim

Gashi

et al. 2022

Preprint

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“…Analyses of EwS tissue was carried out as previously described. 106 On hematoxylin & eosin (HE) stained slides of the EwS xenograft tumors grown in NSG mice, representative areas with vital tumor tissue were marked. Three tissue cores (each 1 mm in diameter) per tumor were extracted from these areas.…”

Section: Methodsmentioning

confidence: 99%