Immuno‐compatibility of amphiphilic ABA triblock copolymer‐based hydrogel films for biomedical applications

Görs, Julia; Roch, Toralf; Tartivel, Lucile; Behl, Marc; Ma, Nan; Lendlein, Andreas

doi:10.1002/pat.3676

Cited by 4 publications

(4 citation statements)

References 40 publications

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“…This photoinitiator was shown to be much less cytotoxic than DMPA , for a similar reactivity with (meth)acrylate moieties. It has been widely used for synthesizing porous photopolymerized hydrogels for biomedical purposes. − However, its drawbacks lie in its low molar absorption coefficient and the need of UV light that may be detrimental to living cells …”

Section: Methodsmentioning

confidence: 99%

“…The concentration of macromonomer also controls the hydrogel pore size. It was usually observed that a higher concentration of precursor led to smaller mesh size. ,, In the case of small organic precursors, e.g., acrylamide monomer and bis(acrylamide) cross-linker, Wang et al , reported a decrease of the pore size with an increase of the monomer concentration, an increase of the cross-linker fraction, and an increase of the UV irradiation intensity. Finally, Cavallo et al reported that irradiation time, ionic strength, and pH might also influence the pore size.…”

Section: Strategies For Generating Porositymentioning

confidence: 99%

“…Equation becomes This technique was successfully applied to various chemically cross-linked hydrogels; see, for instance, refs − . More specifically, it has been used for measuring the pore size of polyacrylamide, poly(vinyl alcohol), or amphiphilic triblock copolymer-based photopolymerized hydrogels. Note that this approach can only be applied to homogeneous hydrogels.…”

Section: Porosity Characterization Techniquesmentioning

confidence: 99%

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Photopolymerized Porous Hydrogels

Nicol

2021

Biomacromolecules

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Hydrogels are polymeric networks highly swollen with water. Because of their versatility and properties mimicking biological tissues, they are very interesting for biomedical applications. In this aim, the control of porosity is of crucial importance since it governs the transport properties and influences the fate of cells cultured onto or into the hydrogels. Among the techniques allowing for the elaboration of hydrogels, photopolymerization or photo-cross-linking are probably the most powerful and versatile synthetic routes. This Review aims at giving an overview of the literature dealing with photopolymerized hydrogels for which the generation or characterization of porosity is studied. First, the materials (polymers and photoinitiating systems) used for synthesizing hydrogels are presented. The different ways for generating porosity in the photopolymerized hydrogels are explained, and the characterization techniques allowing adequate study of the porosity are presented. Finally, some applications in the field of controlled release and tissue engineering are reviewed.

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Section: Methodsmentioning

confidence: 99%

Section: Strategies For Generating Porositymentioning

confidence: 99%

Section: Porosity Characterization Techniquesmentioning

confidence: 99%

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Photopolymerized Porous Hydrogels

Nicol

2021

Biomacromolecules

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“…Hydrogels are versatile in their applications in different fields like industry, [60] removal of metal ions, [61,62] absorption of dyes, [63] controlled released devices in agriculture, [64] diaper industry, [65] biosensors, [66] growth nurseries, [67] water proofing, [68] solar steam generation, [69] 3D printing, [70] permeable membranes, [71] and hygiene products. [72] In biomedical field, hydrogels are employed in drug delivery, [73] wound dressing, [74] actuator, [75] contact lenses, [76] artificial blood vessels, [77] immuno-modulation, [78] cell encapsulation, [79] surgical adhesives, [80] regenerative medicines, [81] and wound healing applications. [82][83][84] In tissue engineering, hydrogels are used as filling agent, support for cells and helper in ideal tissue formation.…”

Section: Applications Of Hydrogelsmentioning

confidence: 99%

Chitosan and Carrageenan‐Based Biocompatible Hydrogel Platforms for Cosmeceutical, Drug Delivery, and Biomedical Applications

et al. 2022

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Hydrogels are three‐dimensional water hungry networks that are currently the focus of intense scientific investigations owing to their potential applications in biomedicine, pharmaceuticals, biotechnology, biosensing, agriculture and cosmetics. Traditional hydrogels are incorporated with toxic cross‐linkers, lower drug loading and are shorter in load bearing capacity. Hydrogels demonstrate significant physiochemical modification in reaction to minor fluctuations in surrounding medium. Therefore, diverse cross‐linkers, polymer blending, modification in polymers/cross‐linkers and addition of reinforcement approaches are used. This review offers a comprehensive overview of application prospects of chitosan and carrageenan‐based hydrogel materials in biomedical sector. Initially, properties of hydrogels, their types, impact of natural‐synthetic polymer blending, requirement of filler and applications of hydrogels are summarized. Afterward, the applications of chitosan and carrageenan hydrogel platforms for drug delivery, tissue engineering, cosmetics, dentistry and ophthalmic treatment are thoroughly vetted. In conclusion, the extraordinary biocompatible, biodegradable and non‐toxic features of chitosan and carrageenan‐based hydrogel systems promote their applicability in biomedical fields.

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An Inverse Shape‐Memory Hydrogel Scaffold Switching Upon Cooling in a Tissue‐Tolerated Temperature Range

Tartivel

Blocki

Braune

et al. 2022

Adv Materials Inter

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either by covalent or physical interaction) is heated above a thermal transition temperature T trans (a glass (T g ) or melting transition temperature (T m )) associated to the switching domains and deformed into a new shape. The temporary shape is obtained after cooling of the sample below T trans and release of external stress. This temporary shape is stable until it is exposed to heat and a switching temperature T sw is exceeded. If the SME is triggered, the material recovers its original shape. It is a one-way effect, meaning that the original shape will not change upon cooling. The fixation of the temporary shape is caused by the formation of temporary cross-links in addition to the netpoints of the polymer network (e.g., phase transition within a semi-crystalline matrix). Various material concepts with sophisticated functions and abilities based on this technology have been reported, [2] e.g., in triblock copolymers from poly(raclactide)-b-poly(propylene oxide)-b-poly(raclactide) dimethacrylates the classical SME functionality based on the T g of the poly(rac-lactide segments) could be combined with degradability. [3] In addition to the classical SME, materials with advanced functions such as triple-or multi-shape-effect were created. [1b,4] Similarly to classical SME, in triple-or multi-shapeeffect polymers the temporary shape is reversed by heating.SME materials have great potential in biomedical application scenarios spanning from a SMP-based self-tightening suture for wound closure up to stents or aneurysm occlusion devices. [5] Of special interest are application scenarios for minimally invasive surgery based on their capability to change shape. So far SMP became elastic when heated. It was the aim of this study to design and fabricate a cell-compatible poly mer-based network with a cooling-induced inverse SME (iSME) within a tissue-tolerated temperature range. In case of an iSME the temporary shape is stable until the material is cooled to T sw . In analogy to the SME, the iSME is a one-time, one-way effect. Once the original shape is recovered, the material does not switch back. Even if heated again, the material remains in its permanent shape obtained during cooling. In this way iSME materials differ from soft artificial muscles (actuators [6] ), who lose their shape obtained during cooling when heated. Potential applications for such a biomaterial system with an iSME are envisaged in soft tissue reconstruction where the device needs to be placed minimally invasively.Soft tissue reconstruction faces various challenges. Current clinically established approaches are based on multiple surgical Tissue reconstruction has an unmet need for soft active scaffolds that enable gentle loading with regeneration-directing bioactive components by soaking up but also provide macroscopic dimensional stability. Here microporous hydrogels capable of an inverse shape-memory effect (iSME) are described, which in contrast to classical shape-memory polymers (SMPs) recover their permanent shape upon cooling. These hyd...

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Immuno‐compatibility of amphiphilic ABA triblock copolymer‐based hydrogel films for biomedical applications

Cited by 4 publications

References 40 publications

Photopolymerized Porous Hydrogels

Photopolymerized Porous Hydrogels

Chitosan and Carrageenan‐Based Biocompatible Hydrogel Platforms for Cosmeceutical, Drug Delivery, and Biomedical Applications

An Inverse Shape‐Memory Hydrogel Scaffold Switching Upon Cooling in a Tissue‐Tolerated Temperature Range

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