Immunizations following solid-organ transplantation

Kumar, Deepali

doi:10.1097/qco.0000000000000078

Cited by 20 publications

(19 citation statements)

References 61 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current standard of care during pre‐LT evaluation involves assessing pretransplant immunity to VPDs. Pediatric patients who are unprotected are offered the MMR or varicella vaccines prior to transplant if possible, with the goal of full immunization and seroconversion prior to transplant . However, these patients remain at risk for loss of immunity even with revaccination.…”

Section: Introductionmentioning

confidence: 98%

“…Live‐attenuated vaccines are not generally recommended in immunocompromised individuals . Post‐LT, pediatric patients on high levels of immunosuppression are considered compromised hosts and as such are unable to receive the MMR or VZV vaccines.…”

Section: Introductionmentioning

confidence: 99%

“…Live-attenuated vaccines are not generally recommended in immunocompromised individuals. 5,6 Post-LT, pediatric patients on high levels of immunosuppression are considered compromised hosts and as such are unable to receive the MMR or VZV vaccines. Historically, the widespread administration of vaccines and resulting herd immunity in the United States helped protect transplant patients.…”

Section: Introductionmentioning

confidence: 99%

“…Pediatric patients who are unprotected are offered the MMR or varicella vaccines prior to transplant if possible, with the goal of full immunization and seroconversion prior to transplant. 5 However, these patients remain at risk for loss of immunity even with revaccination. Pediatric studies have demonstrated that waning immunity following LT is a significant issue placing patients at risk for contracting VPDs.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Measles, mumps, rubella (vaccine) and varicella vaccines in pediatric liver transplant: An initial analysis of post‐transplant immunity

Yoeli

Miloh

et al. 2019

Pediatric Transplantation

View full text Add to dashboard Cite

Varicella and measles infection represents a significant source of morbidity and mortality for pediatric LT recipients. We evaluated the prevalence and correlates of post‐transplant immunity in pediatric LT recipients previously immunized against measles (n = 72) and varicella (n = 67). Sixteen of seventy‐two (22%) patients were measles non‐immune, and 42/67 (63%) were varicella non‐immune after LT. Median time from LT to titers for measles and varicella was 4.0 and 3.3 years, respectively. In the measles cohort, non‐immune patients received fewer pretransplant vaccine doses (P = 0.026) and were younger at both time of vaccination (P = 0.006) and LT (P = 0.004) compared with immune patients. Upon multivariable analysis, weight > 10 kg at LT (OR 5.91, 95% CI 1.27‐27.41) and technical variant graft (OR 0.07, 95% CI 0.01‐0.37) were independently, significantly associated with measles immunity. In the varicella cohort, non‐immune patients received fewer pretransplant vaccine doses (P = 0.028), were younger at transplant (P = 0.022), and had less time lapse between their last vaccine and transplant (P = 0.012) compared with immune patients. Upon multivariate analysis, time > 1 year from last vaccine to LT was independently, significantly associated with varicella immunity (OR 3.78, CI 1.30‐11.01). This study demonstrates that non‐immunity to measles and varicella is a prevalent problem after liver transplantation in children and identifies 3 unique risk factors for non‐immunity in this high‐risk population.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Measles, mumps, rubella (vaccine) and varicella vaccines in pediatric liver transplant: An initial analysis of post‐transplant immunity

Yoeli

Miloh

et al. 2019

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…The guidelines recommend that the influenza vaccine be given both pre-transplant and post-transplant. It is thought that the timing of influenza vaccination post-transplant is key to immunologic response, although there are limited data regarding optimal timing post-transplant (12,13). The Advisory Committee on Immunization Practices (ACIP) makes no specific recommendation regarding the timing of the influenza vaccine in SOT recipients (14).…”

mentioning

confidence: 99%