Immunizations at Wisconsin Pharmacies: Results of a statewide vaccine registry analysis and pharmacist survey

Ber`ce, Philip; Bernstein, Rebecca; MacKinnon, Gregory; Sorum, Sarah; Martin, Enrico; MacKinnon, Karen J.; Rein, Lisa; Schellhase, Kenneth G.

doi:10.1016/j.vaccine.2020.04.043

Cited by 13 publications

(34 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…abstracted and synthesized all findings. Barrier type categorization was adapted from the findings reported in the included studies [15][16][17]. Some barriers extended, at least partially, across other barrier types.…”

Section: Study Selection and Data Extractionmentioning

confidence: 99%

“…The electronic database searches yielded 444 articles; 292 titles and abstracts were selected, and 13 full-text studies were reviewed for inclusion. In the end, 6 out of 13 studies were selected for this review using the exclusion and inclusion criteria [15][16][17][18][19][20]. Figure 1 illustrates the PRISMA diagram detailing the search and selection process.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…Figure 1 illustrates the PRISMA diagram detailing the search and selection process. Four of the studies [15,16,18,20] examined barriers related to HPV vaccine alone, while the remaining two studies [17,19] included other vaccines in addition to HPV. All included studies were carried out in the United States; however, geographical location and pharmacy setting differ across studies (Table 1).…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…Table 3 presents a summary of the key findings for the included studies. These findings were further grouped by level of barrier into patient, parental, (pharmacist's) personal, and system/organization barrier groups, which were adapted from the findings reported in the included studies (Table 4) [15][16][17]. Some barriers extended, at least partially, across other barrier types.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Pharmacists’ Perceived Barriers to Human Papillomavirus (HPV) Vaccination: A Systematic Literature Review

et al. 2021

View full text Add to dashboard Cite

About 45:000 cancers are linked to HPV each year in the United States alone. The HPV vaccine prevents cancer and is highly effective, yet vaccination coverage remains low. Pharmacies can play a meaningful role in increasing HPV vaccination access due to their availability and convenience. However, little is known about pharmacists’ perceived barriers to HPV vaccination. The objective of this systematic review was to summarize existing literature on perceived barriers to administering HPV vaccination reported by pharmacists. Barriers identified from selected studies were synthesized and further grouped into patient, parental, (pharmacist’s) personal, and system/organization barrier groups. Six studies were included in this review. The cost of the HPV vaccine, insurance coverage and reimbursement were commonly reported perceived barriers. Adolescent HPV vaccination barriers related to parental concerns, beliefs, and inadequate knowledge about the HPV vaccine. Perceived (pharmacist’s) personal barriers were related to lack of information and knowledge about HPV vaccine and recommendations. At the system/organization level, barriers reported included lack of time/staff/space; difficulty in series completion; tracking and recall of patient; perceived competition with providers; and other responsibilities/vaccines taking precedence. Future strategies involving pharmacy settings in HPV-related cancer prevention efforts should consider research on multilevel pharmacy-driven interventions addressing barriers.

show abstract

Section: Study Selection and Data Extractionmentioning

confidence: 99%

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacists’ Perceived Barriers to Human Papillomavirus (HPV) Vaccination: A Systematic Literature Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Better understanding the relationship between PD‐1 and IL‐15 regulation has important implications for tumour immunology. The intratumoural levels of IL‐15 have been previously shown to play an essential role in tumour regression [47], although it has also been shown that IL‐15 may cause upregulation of surface PD‐1 [48, 49]. These two findings appear to be at odds, but may suggest a potential feedback or T‐cell inhibition mechanism.…”

Section: Discussionmentioning

confidence: 99%

PD‐1‐induced proliferating T cells exhibit a distinct transcriptional signature

et al. 2021

View full text Add to dashboard Cite

Summary Ligation of the inhibitory receptor PD‐1 on T cells results in the inhibition of numerous cellular functions. Despite the overtly inhibitory outcome of PD‐1 signalling, there are additionally a collection of functions that are activated. We have observed that CD4+ T cells stimulated through the T‐cell receptor and PD‐1 primarily do not proliferate; however, there is a population of cells that proliferates more than T‐cell receptor stimulation alone. These highly proliferating cells could potentially be associated with PD‐1‐blockade unresponsiveness in patients. In this study, we have performed RNA sequencing and found that following PD‐1 ligation proliferating and non‐proliferating T cells have distinct transcriptional signatures. Remarkably, the proliferating cells showed an enrichment of genes associated with an activated state despite PD‐1 signalling. Additionally, circulating follicular helper T cells were significantly more prevalent in the non‐proliferating population, demonstrated by enrichment of the associated genes CXCR5, CCR7, TCF7, BCL6 and PRDM1 and validated at the protein level. Translationally, we also show that there are more follicular helper T cells in patients that respond favourably to PD‐1 blockade. Overall, the presence of transcriptionally and functionally distinct T cell populations responsive to PD‐1 ligation may provide insights into the clinical differences observed following therapeutic PD‐1 blockade.

show abstract

Pharmacists' perceived barriers and facilitators as immunisers: Mapping COM‐B model to support intervention development

Teo,

Yaw,

Kum

et al. 2023

J Am Coll Clin Pharm

View full text Add to dashboard Cite

IntroductionPharmacists were involved in the education and facilitation of vaccine administration, including more recent roles in vaccine administration. Yet there is a lack of reviews about pharmacists’ motivation as immunisers to improve understanding of the possible gaps in the uptake of the professional roles.ObjectiveThis review aimed to identify perceived barriers and facilitators of pharmacists as immunisers and mapped across the Capability, Opportunity, and Motivation Model of Behaviour (COM‐B).MethodsA total of 5429 articles were identified in four databases from inception until December 2022. Studies exploring pharmacists’ perceptions and attitudes towards their role in vaccine administration were included. Using thematic analysis, the findings were mapped onto the COM‐B model components. All findings are reported following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guideline.ResultsTwenty‐six studies were included in the review. Themes of facilitators and barriers were identified in components of physical capability (training and certificate program), psychological capability (knowledge and awareness), physical opportunity (time and space), social opportunity (support from patients, staff, and general practitioners), reflective motivation (cost and expansion of role) and automatic motivation (legislation and reimbursement).ConclusionBy integrating these findings into the COM‐B framework, a holistic roadmap can assist policymakers in aligning strategies for effective pharmacist‐led vaccinations.This article is protected by copyright. All rights reserved.

show abstract

Immunizations at Wisconsin Pharmacies: Results of a statewide vaccine registry analysis and pharmacist survey

Cited by 13 publications

References 24 publications

Pharmacists’ Perceived Barriers to Human Papillomavirus (HPV) Vaccination: A Systematic Literature Review

Pharmacists’ Perceived Barriers to Human Papillomavirus (HPV) Vaccination: A Systematic Literature Review

PD‐1‐induced proliferating T cells exhibit a distinct transcriptional signature

Pharmacists' perceived barriers and facilitators as immunisers: Mapping COM‐B model to support intervention development

Contact Info

Product

Resources

About