Immunization with centrin-Deficient Leishmania braziliensis Does Not Protect against Homologous Challenge
Francys Avendaño-Rangel,
Gabriela Agra-Duarte,
Pedro B. Borba
et al.
Abstract:Immunization with various Leishmania species lacking centrin induces robust immunity against a homologous and heterologous virulent challenge, making centrin mutants a putative candidate for a leishmaniasis vaccine. Centrin is a calcium-binding cytoskeletal protein involved in centrosome duplication in higher eukaryotes and Leishmania spp. lacking centrin are unable to replicate in vivo and are non-pathogenic. We developed a centrin-deficient Leishmania braziliensis (LbCen−/−) cell line and confirmed its impai… Show more
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