Immunization Therapy of Warts

Biberstein, Hans

doi:10.1001/archderm.1944.01510130015005

Cited by 63 publications

(9 citation statements)

References 17 publications

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“…There are many methods of immunotherapy for warts, such as vaccination for wart (21), smallpox vaccination (22), and contact sensitization with DNCB (14)(15)(16)(17)(18)(19)23). DNCB application is the most widely used, especially in cases of recurrent or resistant warts, verruca plana, long lasting warts, or subungual or mucosal Warts (14,15).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cimetidine on Verruca Plana Juvenilis: Clinical Trials in Six Patients

Choi

Hann

Park

1993

The Journal of Dermatology

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Cimetidine is an H2-receptor antagonist which is mainly used to treat gastrointestinal diseases. Recently, many authors have suggested that cimetidine has the ability to reverse acquired tolerance to dinitrochlorobenzene (DNCB). We have used cimetidine in six patients with verruca plana who showed no therapeutic response to DNCB. Four of them responded and showed complete disappearance of the verruca plana. The mean duration of oral cimetidine administration (1.2 g/day) was 4 weeks until the disappearance. Therefore, we suggest that oral cimetidine can be used as an effective and safe adjunctive modality for the treatment of verruca plana.

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Section: Discussionmentioning

confidence: 99%

The Effect of Cimetidine on Verruca Plana Juvenilis: Clinical Trials in Six Patients

Choi

Hann

Park

1993

The Journal of Dermatology

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“…Biberstein's report in 1944 of autogenous vaccination described in particular the treatment of condyloma acuminata. Biberstein theorized that the viral warts were eradicated by a more direct antigen presentation to the skin, which triggered a host response.…”

Section: The Origins Of Immunotherapy In Dermatologymentioning

confidence: 99%

A brush with danger: historical review of topical immunotherapy for alopecia areata

Macbeth

Lee

Levell

2013

Clinical and Experimental Dermatology

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“…In 1944, Biberstein first described the use of immunotherapy with an autologous vaccine in the treatment of condylomata acuminatum. 62 Although efforts have been made for a vaccine, 24 they have not been widely effective. More recently, HPV vaccines targeting the late structural proteins of the viral capsid (E6, E7) have shown more promise.…”

Section: Vaccinementioning

confidence: 99%