Immunization Therapy of Warts

Biberstein, Hans

doi:10.1001/archderm.1945.01510250039014

Cited by 6 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complete clearance has been reported as 20-74.1% in various studies on autoinoculation. [2][3][4][5][6][7][8][9][10][11] We found improvement with autoinoculation therapy as early as 2 weeks. Other workers have reported improvement occurring earliest at 3 weeks and 4 weeks.…”

Section: Subgroup Analysismentioning

confidence: 99%

Role of autoinoculation in the management of cutaneous warts: a comparison study with 100% tricholoroacetic acid application

Faleiro

Shukla

2020

Int J Res Dermatol

View full text Add to dashboard Cite

Background: Persistent and recurrent warts pose a challenge to physicians despite the availability of multiple treatment options. Autoinoculation exposes HPV antigens to the dermis and vasculature thereby activating a delayed hypersensitivity response, facilitating clearance of both local and distant warts. The aim of this study was to assess the efficacy of autoinoculation and compare it with chemical cautery using 100% trichloroacetic acid.Methods: A non-blinded interventional study was conducted at Goa Medical College, a tertiary care centre. Non-immunocompromised patients with 5 or more non-genital warts were included. Group 1: a wart was removed by punch biopsy, minced and implanted in the dermis. The procedure was repeated at 4 and 8 weeks. Group 2: weekly trichloroacetic acid (100%) application. Response was assessed at 4, 8 and 12 weeks in terms of percentage reduction in the number of warts. Statistical correlation with respect to age, sex, duration, number and type of warts was assessed using Welch ANOVA.Results: In group 1, 63 patients and in group 2, 54 patients completed the study. Post autoinoculation, complete clearance was seen in 46.0% and 3.2% had partial clearance. With TCA application, 33.3% patients had complete and 13% had partial clearance. Response differed with the type of warts. Palmoplantar, periungual warts and verruca vulgaris showed better response to autoinoculation. Filiform and plane warts showed better response to TCA.Conclusions: Autoinoculation is an efficacious treatment modality which can be performed routinely especially for palmoplantar and periungual warts which are particularly challenging to treat with other modalities.

show abstract

Section: Subgroup Analysismentioning

confidence: 99%

Role of autoinoculation in the management of cutaneous warts: a comparison study with 100% tricholoroacetic acid application

Faleiro

Shukla

2020

Int J Res Dermatol

View full text Add to dashboard Cite

show abstract

“…No antiwart vaccine has yet been formu lated [17,18], Since many patients with mul tiple warts often have defective cell-mediat ed mechanisms [19,20], experiments have been made with immunomodulator agents. The first to be tried was dinitrochlorobenzene [21][22][23][24][25], which subsequently proved to be mutagenic [26,27], Squaric acid dibutylester and diphenciprone (DPCP) have no such risks [28].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Multiple Relapsing Warts with Diphenciprone

Orecchia

Douville²,

Santagostino³

et al. 1988

Dermatology

View full text Add to dashboard Cite

44 patients with multiple recalcitrant warts were treated with weekly applications of diphencyprone. 20 patients were cured completely and 17 improved with reduction in the number or dimension of warts. Plantar warts responded less satisfactorily. Sensitization is not always tolerated by patients and the risk of eczema spreading to other sites must be considered. However, topical immunotherapy has to be considered as an alternative means of treatment in selected patients. The mode of action is discussed.

show abstract

“…In the 1930s and 1940s a number of therapeutic vaccination trials were performed based on the injection of autologous and heterologous wart extracts. During his trials, Biberstein inoculated hundreds of patients with filtered extracts from warts and condylomas and was able to record wart regression in the majority of the cases [3]. The likely involvement of the immune system in controlling papillomavirus infections was also underlined by the observation that genital warts but also genital cancer is more frequently found in immuno-suppressed patients [49].…”

Section: Therapeutic Approachesmentioning

confidence: 99%