Immunization prevents DDT buildup in mouse tissues

Hrafnkelsdottir, Kolbrun; Valgeirsson, Jon; Bjarnadottir, Sesselja; Ólafsdóttir, Sigríður; Ólafsdóttir, Kristín; Hedinsdottir, Sigurlina T.; Magnúsdóttir, Elín V.; Gizurarson, Sveinbjörn

doi:10.1016/j.intimp.2007.04.012

Cited by 4 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aim of these vaccines is to generate antibodies that reduce blood concentrations of the given drug and its effect on the central nervous system by preventing the drug from crossing the blood-brain barrier. The experimental strategies to induce protective and specific antibodies against cocaine included subcutaneous and intranasal immunization (Hrafnkelsdottir et al, 2007). Preclinical studies using KLH as a carrier of these drugs are promising (Moreno and Janda, 2009).…”

Section: Vaccines Against Abused Drugsmentioning

confidence: 99%

Mollusk Hemocyanins as Natural Immunostimulants in Biomedical Applications

Becker¹,

Arancibia²,

Salazar³

et al. 2014

Immune Response Activation

View full text Add to dashboard Cite

Section: Vaccines Against Abused Drugsmentioning

confidence: 99%

Mollusk Hemocyanins as Natural Immunostimulants in Biomedical Applications

Becker¹,

Arancibia²,

Salazar³

et al. 2014

Immune Response Activation

View full text Add to dashboard Cite

Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells

Kajta

Litwa

Rzemieniec

et al. 2014

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Schijns

Fernández‐Tejada

Barjaktarović

et al. 2020

Immunological Reviews

View full text Add to dashboard Cite

Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non‐infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination can at least in principle be proposed as a therapeutic strategy. Understanding the nature of protective immunity is of vital importance, and the progress made in recent years in defining the nature of pathological and protective immunity for a range of diseases has provided an impetus to devise strategies to promote such responses in a targeted manner. However, in many cases, limited progress has been made in clinical adoption of such approaches. This in part results from a lack of safe and effective vaccine adjuvants that can be used to promote protective immunity and/or reduce deleterious immune responses. Although somewhat simplistic, it is possible to divide therapeutic vaccine approaches into those targeting conditions where antibody responses can mediate protection and those where the principal focus is the promotion of effector and memory cellular immunity or the reduction of damaging cellular immune responses as in the case of autoimmune diseases. Clearly, in all cases of antigen‐specific immunotherapy, the identification of protective antigens is a vital first step. There are many challenges to developing therapeutic vaccines beyond those associated with prophylactic diseases including the ongoing immune responses in patients, patient heterogeneity, and diversity in the type and stage of disease. If reproducible biomarkers can be defined, these could allow earlier diagnosis and intervention and likely increase therapeutic vaccine efficacy. Current immunomodulatory approaches related to adoptive cell transfers or passive antibody therapy are showing great promise, but these are outside the scope of this review which will focus on the potential for adjuvanted therapeutic active vaccination strategies.

show abstract

Immunization prevents DDT buildup in mouse tissues

Cited by 4 publications

References 32 publications

Mollusk Hemocyanins as Natural Immunostimulants in Biomedical Applications

Mollusk Hemocyanins as Natural Immunostimulants in Biomedical Applications

Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Contact Info

Product

Resources

About