Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles

Frey, Andreas; Mantis, Nicholas J.; Kozlowski, Pamela A.; Quayle, Alison J.; Bajardi, Adriana; Perdomo, Juana J.; Robey, Frank A.; Neutra, Marian R.

doi:10.1016/s0264-410x(99)00163-2

Cited by 46 publications

(25 citation statements)

References 44 publications

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“…The dot shown here is simple, but more complex core/shell arrangements of two crystal types are used to produce dots with emissions at longer wavelengths, for example, in the infrared incorporated per nanoparticle. Metal oxide nanoparticles based on metals other than iron have been used to perform vaccination, based on oligopeptides attached to any of the range of metal oxide nanoparticles, including the particles (Frey et al 1997(Frey et al , 1998.…”

Section: Metal Oxidesmentioning

confidence: 99%

Molecular imaging with nanoparticles: giant roles for dwarf actors

Debbage

Jaschke

2008

Histochem Cell Biol

233

212

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Molecular imaging, first developed to localise antigens in light microscopy, now encompasses all imaging modalities including those used in clinical care: optical imaging, nuclear medical imaging, ultrasound imaging, CT, MRI, and photoacoustic imaging. Molecular imaging always requires accumulation of contrast agent in the target site, often achieved most efficiently by steering nanoparticles containing contrast agent into the target. This entails accessing target molecules hidden behind tissue barriers, necessitating the use of targeting groups. For imaging modalities with low sensitivity, nanoparticles bearing multiple contrast groups provide signal amplification. The same nanoparticles can in principle deliver both contrast medium and drug, allowing monitoring of biodistribution and therapeutic activity simultaneously (theranostics). Nanoparticles with multiple bioadhesive sites for target recognition and binding will be larger than 20 nm diameter. They share functionalities with many subcellular organelles (ribosomes, proteasomes, ion channels, and transport vesicles) and are of similar sizes. The materials used to synthesise nanoparticles include natural proteins and polymers, artificial polymers, dendrimers, fullerenes and other carbon-based structures, lipid-water micelles, viral capsids, metals, metal oxides, and ceramics. Signal generators incorporated into nanoparticles include iron oxide, gadolinium, fluorine, iodine, bismuth, radionuclides, quantum dots, and metal nanoclusters. Diagnostic imaging applications, now appearing, include sentinal node localisation and stem cell tracking.

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Section: Metal Oxidesmentioning

confidence: 99%

Molecular imaging with nanoparticles: giant roles for dwarf actors

Debbage

Jaschke

2008

Histochem Cell Biol

233

212

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“…The first involves placing the aluminum suspension into the solution containing the antigen to form a protein-aluminum salt complex, and the other is putting the solution containing the antigen into Al(OH) 3 solution or aluminum phosphate to form aluminum-containing vaccines. Recent studies found that making the aluminum adjuvant into nanometer form could induce the specific antibody in mice quickly and at a high level, and that compared with other forms of aluminum adjuvant, it could induce humoral immunity earlier (Frey et al, 1999). After consulting the relevant literature, we found the amount of OVA used in animal models generally ranges from 10 to 100 μg (Yamaki et al, 2005;Tumes et al, 2007;Liu et al, 2010;Oh et al, 2011), whereas the amount of Al(OH) 3 ranges from 1 and 5 mg.…”

Section: Discussionmentioning

confidence: 93%

Role of aluminum adjuvant in producing an allergic rhinitis animal model

Fan

Zhao

et al. 2014

Genet. Mol. Res.

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ABSTRACT. This study evaluated different dosage forms of aluminum adjuvant in generating allergic rhinitis animal models. Forty female BALB/c mice were assigned to four groups, including three dosage forms of aluminum adjuvant [powder, gel, and hydrosolvent of aluminum hydroxide, Al(OH) 3 ] mixed with ovalbumin to simulate the symptoms of allergic rhinitis and one control group. Although the aluminum adjuvants were in different dosage forms, the content was 5 mg after conversion in all groups. The fourth group was given normal saline instead as a control. Mice of the powder group displayed typical symptoms of allergic rhinitis. We also found discrete eosinophils in the nasal mucosa of mice from the hydrosolvent group; however, no eosinophils were found in the gel group. These two groups both displayed cytotoxic symptoms and foreign body granuloma. Aluminum adjuvant used in producing animal models can induce foreign body granuloma and other untoward reactions, which are associated with the

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“…There is evidence that humoral and cellular immunity are important for preventing viral pathogens such as HIV. Andreas Frey et al [13] co-link the HIV-1gp 120 C4 region to the peptide co-conjugate to the nano-Al2O3 adjuvant. Compared with the adjuvant MDP (hydrophilic muramyl dipeptide), nano-Al2 O3 Can induce the strongest antibody titers and have the strongest reactivity to HIV-1gp 120-infected cells.…”

Section: Construction and Immunological Evaluation Of Inorganic Nanocmentioning

confidence: 99%

Construction and Immunological Evaluation of Immunostimulatory Nanocomposites with Vaccine Potential

Zhong¹,

Zhuang²

2017

J Infect Dis Ther

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For a long time, the most important means of controlling infectious diseases is prevention, and vaccination is considered the most effective measures, so the preparation and improvement of the vaccine is not only supported by the medical profession, it is the concern of the broad masses of the people. A number of biomolecules have been used as antigens to construct novel vaccine preparations, including Virus-like particles (VLPs) or bacteria, dendritic cells, nucleic acids and peptides. Immunostimulatory nanocomposites are based on the above molecules as vectors, encapsulating immune adjuvants, and nanoparticles for the construction of novel vaccines. Compared to traditional vaccines, adjuvants, nanoparticles alone, the efficacy of immunostimulatory nanocomposites as potential vaccines shows increased CD4 + , CD8+ T cell count, secretion of cytokine interferon-gamma and IL-4 functions also significantly enhanced, in addition, the use of nanoparticles enhances the Immune irritation of adjuvants, VLPs and other molecules on humoral and cellular immune responses. Thus, immunostimulatory nanocomposites may be potential vaccines for future prevention and treatment applications.

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Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles

Cited by 46 publications

References 44 publications

Molecular imaging with nanoparticles: giant roles for dwarf actors

Molecular imaging with nanoparticles: giant roles for dwarf actors

Role of aluminum adjuvant in producing an allergic rhinitis animal model

Construction and Immunological Evaluation of Immunostimulatory Nanocomposites with Vaccine Potential

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