Immunization against Marek's Disease: Influence of Strain of Chickens, Maternal Antibody, and Type of Vaccine

Jl, Spencer; Js, Gavora; Grunder, A. A.; Robertson, Alan; Gw, Speckmann

doi:10.2307/1589239

Cited by 42 publications

(13 citation statements)

References 16 publications

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“…Failures have been attributed to several factors such as inadequate vaccine production methods (Thorton et al, 1975) or mismanagement of vaccine at the hatcheries (Halvorson and Mitchell, 1979). The influence of genetic resistance to MD (Spencer et al, 1974) or the presence of maternal antibodies against HVT (Calnek and Smith, 1972, and others) have also been indicated as possible reasons for vaccination failures. Common poultry operation practices such as multi-age rearing and insufficient cleaning between generations of chickens could be responsible for a heavy and early exposure to MDV, before vaccinal immunity develops.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of two highly oncogenic strains of Marek's disease virus¹²

1982

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SUMMARYThe RB-1B and ALA-8 strains of Marek's disease (MD) virus, which were isolated from chickens with MD and which had been vaccinated with the herpesvirus of turkeys (HVT), were evaluated for their oncogenic potential in genetically susceptible (P-line) and resistant (N-line, PDRC) chickens. RB-1B and ALA-8 were both highly oncogenic, causing a high incidence of MD in both susceptible and resistant birds. Vaccination of P-line birds with SB-1 or HVT did not protect satisfactorily against RB-1B. However, a bivalent vaccine consisting of SB-1 and HVT enhanced protection significantly. HVT alone, and the bivalent vaccine, protected PDRC and N-line chickens well against RB-1B, but SB-1 was less protective in PDRC birds. HVT protected equally well against challenge with ALA-8 and the standard JM-10 strain. Differences in the pathogenesis of viral infection could not be detected among ALA-8, RB-1B and JM-10 between 4-7 days postinfection (d.p.i.). However, after d.p.i. 12 RB-1B caused significantly higher levels of viral internal antigen and virus isolation rates than did JM-10 in the same genetic strain. Prior vaccination prevented the expression of ALA-8 at 5 and 20 d.p.i., but not that of RB-1B. Pathogenetic events such as expression of VIA or level of virus infection appeared to be directly related to the level of protection observed in challenged birds.

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Section: Introductionmentioning

confidence: 99%

Characterisation of two highly oncogenic strains of Marek's disease virus¹²

1982

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“…Also, chicken lines selected for MD resistance have been shown to have greater vaccinal immunity and higher egg production than susceptible lines (16)(17)(18). If genes conferring genetic resistance to MD could be identified or located, poultry breeders would be able to directly select for enhanced MD resistance through the use of genetic markers, eliminating the need for progeny or sibling testing and the use of pathogenic agents.…”

mentioning

confidence: 99%

Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken

Liu

Kung²,

Fulton

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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Marek's disease (MD) is a lymphoproliferative disease of chickens induced by a herpesvirus, the MD virus (MDV). Because MD is a significant economic problem to the poultry industry, there is great interest in enhancing genetic resistance, which is controlled by multiple genes. The influence of the MHC has been clearly demonstrated, and several relevant quantitative trait loci have been mapped; however, no single gene influencing MD resistance has been identified. Transcription of SORF2 is perturbed in the MDV recombinant clone RM1 due to a solo insertion of the reticuloendotheliosis virus long terminal repeat, which may explain the loss of oncogenicity for this strain. Hypothesizing that SORF2-interacting host proteins are involved in MD resistance, we screened a chicken splenic cDNA library by the yeast two-hybrid assay using SORF2 as bait. The chicken growth hormone (GH) structural peptide was identified, and the specific interaction was verified by coimmunoprecipitation. Immunohistochemical staining and indirect immunofluorescence assay indicated that GH and SORF2 can be coexpressed in MDV-infected cells both in vitro and in vivo. Furthermore, polymorphism in the GH gene (GH1) is associated with the number of tissues with tumors in commercial White Leghorn chickens with the MHC B*2͞B*15 genotype. We conclude that GH1 may well be a MD resistance gene.

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“…It has been observed that such antibodies can indeed interfere, doing so more strongly against the homologous virus than against the heterologous virus. Thus, antibodies to HVT, but not to MDV, interfere with HVT vaccination, and cell-free HVT is more susceptible than cell-associated HVT Churchill et al, 1973;Spencer et al, 1974;Yoshida et al, 1975;King et al, 1981). The differential effect of HVT antibodies on the two types of HVT is clearly demonstrated by the higher PDso value for cell-free HVT in passively immune chicks already mentioned (Witter and Burmester, 1979).…”

Section: Effect Of Maternal Antibody On Vaccinationmentioning

confidence: 97%

“…Maternal antibody to HVT will similarly retard the development of infection in progeny vaccinated with HVT and interfere with the onset of vaccinal immunity Spencer et al, 1974) (see Section VII.D.2).…”

Section: Mechanisms Of Depressed Responsivenessmentioning

confidence: 99%

The Herpesviruses

1982

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Immunization against Marek's Disease: Influence of Strain of Chickens, Maternal Antibody, and Type of Vaccine

Cited by 42 publications

References 16 publications

Characterisation of two highly oncogenic strains of Marek's disease virus¹²

Characterisation of two highly oncogenic strains of Marek's disease virus¹²

Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken

The Herpesviruses

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Immunization against Marek's Disease: Influence of Strain of Chickens, Maternal Antibody, and Type of Vaccine

Cited by 42 publications

References 16 publications

Characterisation of two highly oncogenic strains of Marek's disease virus12

Characterisation of two highly oncogenic strains of Marek's disease virus12

Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken

The Herpesviruses

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Characterisation of two highly oncogenic strains of Marek's disease virus¹²

Characterisation of two highly oncogenic strains of Marek's disease virus¹²