Immunity, Sex Hormones and Infection

Bini, Estela Isabel; Hernández-Pando, Rogelio

doi:10.3233/nib-2011-010

Cited by 5 publications

(3 citation statements)

References 168 publications

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“…Table (1) revealed that all hormones are significantly increased except FSH was significantly decreased in the infected group when compared with a control group. The studies revealed the relationship of sex hormones with cutaneous leishmaniasis is very rare, on the other hand, little in several studies have been conducted on the relationship between sex hormones with visceral leishmaniases, such as Verde (2011), showed the normal level of FSH hormone and an elevated LH and a decrease in Testosterone in patients with visceral leishmaniasis, in ages of the patients were close to the ages of the patients of the current study (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) years of infection group.…”

Section: Resultssupporting

confidence: 64%

Physiological Assessment of Sex Hormones in Infected Women with Cutaneous Leishmania

Ali

Muhsen

Muhsen³

2023

J. Res. Appl. Sci. Biotechnol.

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The results of the clinical and laboratory examination showed 60 samples of women with cutaneous leishmaniasis in Salah Al-Din Governorate for the period from January to March 2022, during this research, the effect of skin leishmaniasis infection on the level of sex hormones (LH, Estrogen, Testosterone, FSH) was known, where the results were an increase in the level of LH, Estrogen, Testosterone, while the level of FSH hormone decreased in females compared to the control group.

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Section: Resultssupporting

confidence: 64%

Physiological Assessment of Sex Hormones in Infected Women with Cutaneous Leishmania

Ali

Muhsen

Muhsen³

2023

J. Res. Appl. Sci. Biotechnol.

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“…The concentration of estrogen interferes with the activity of many immune cells and lymphoid organs, because of the existence of hormone receptors on these cells (Bini et al, 2011), Craig et al (2001) Explained that High concentrations of estrogen facilitates infection of parasites, while Kittas et al (1979) suggests that prolonged administration of hexo-estrol leads to atrophy of the thymus gland and the strong integration of the thymus-dependent areas of the lymph nodes and spleen, thus drop of immunity and severe disease in animals hose infected with parasites.…”

Section: Resultsmentioning

confidence: 99%

The role of Toxoplasma gondii in concentration of some sex hormones in infertile individual

Al-Ardi¹

2021

Journal of Medical and Pharmaceutical Sciences

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The main objective: Link the incidence of the Toxoplasma gondii present and manifestations of some sex hormones ‎ at ‎infertile persons.‎ Follicle-stimulating hormone (FSH), 17-β Estradiol (E2), and testosterone are key ‎regulators for the development ‎and progress of germline cells. Also affect many defensive ‎functions to the ‎immune system. Toxoplasma gondii attempts to manipulating these ‎Hormones concentration to their survive. ‎ ‎The study methodology‎‏:‏‎ since October 2018 tell 31th March 2019, 100 samples of the blood of ‎infertile ‎patients have been collected from both sexes from outpatient clinics in ‎different areas of ‎Qadisiyah governorate, Iraq. All there examined with Elisa test to detect IgM and IgG ‎antibodies against T. gondii and to estimate concentration of sex hormones. ‎ Results: ‎ 39 samples (39 %) were positive to T. gondii. IgM positive ‎samples were (6 and ‎‎10) with (12% and 20%) at male and female, Positive IgG samples for male ‎and female were (10 and 13) ‎with (20% and 26%).‎ In male, Testosterone ‎concentrations were increased in infected where were (5.4 and 5) ng/ ml with IgG and IgM ‎test. Also E2 were (33.6 and 35) pg/ ml with IgG and IgM infected men ‎. While FSH concentrations were decreased in (12.1 and 12.3) IU with IgG and ‎IgM. In female, FSH and E2 concentrations were increased in infected female, ‎where were (5.45 and 5.9)IU/ ml and (260 and 250)pg/ ml from both hormones with IgG ‎and IgM test. Testosterone concentration was decreased (0.98)ng/ ml with IgG, ‎but increased (1.35) ng/ ml with IgM in female. ‎ ‎The study has been showed that a significant difference in the concentrations ‎of hormones studied ‎between non-infected and infected samples in ‎the acute case, and did not register a ‎significant difference between ‎chronic infection and non-infection, a significant increase ‎in ‎hormones Testosterone and E2 in male and female while FSH in ‎female only, FSH ‎concentration was lower in male after infection.‎ Conclusion: in light the study results the author see that: Infection with the parasite is associated with significant changes ‎in the ‎concentrations of sex hormones in infertile peoples, therefore ‎it can be said that infection ‎with Toxoplasma gondii is one of the ‎main causes of infertility in both sexes.‎ ‎ ‎Suggestions:‎ ‎Conduct broader studies by examining more people and ‎determine the relationship ‎between infertility and sex hormone ‎concentration with infection by T. gondii in girls and ‎boys before ‎or after puberty.‎

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“…As well as modulating each other production, adrenal and sex steroids have important effects on immune cell development and function, mainly because immune cells express diverse hormone receptors [10]. It follows that interactions between the HPG and HPA axes with the immune system are to a great extent involved in the ultimate effects of the anti-infectious response.…”

Section: Introductionmentioning

confidence: 99%

The implication of pro-inflammatory cytokines in the impaired production of gonadal androgens by patients with pulmonary tuberculosis

et al. 2015

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Immunity, Sex Hormones and Infection

Cited by 5 publications

References 168 publications

Physiological Assessment of Sex Hormones in Infected Women with Cutaneous Leishmania

Physiological Assessment of Sex Hormones in Infected Women with Cutaneous Leishmania

The role of Toxoplasma gondii in concentration of some sex hormones in infertile individual

The implication of pro-inflammatory cytokines in the impaired production of gonadal androgens by patients with pulmonary tuberculosis

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