2019
DOI: 10.1016/j.dci.2019.03.019
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Immunity of fleas (Order Siphonaptera)

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Cited by 14 publications
(15 citation statements)
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References 45 publications
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“…Although trypsin and chymotrypsin are primarily considered blood feeding-associated molecules, the presence of ingested pathogens seems to modulate their abundance (Brown, 2019). In our study, serine proteases were associated with the B. henselae infection status of C. felis, suggesting an additional role in the flea immune response, as previously reported (Dreher-Lesnick et al, 2010;Brown, 2019;Bland et al, 2020).…”
Section: Serine Proteasessupporting
confidence: 80%
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“…Although trypsin and chymotrypsin are primarily considered blood feeding-associated molecules, the presence of ingested pathogens seems to modulate their abundance (Brown, 2019). In our study, serine proteases were associated with the B. henselae infection status of C. felis, suggesting an additional role in the flea immune response, as previously reported (Dreher-Lesnick et al, 2010;Brown, 2019;Bland et al, 2020).…”
Section: Serine Proteasessupporting
confidence: 80%
“…Similar to several other blood-sucking insects, C. felis has a plethora of serine proteases (Gaines et al, 1999), which play a role in numerous biological processes, including but not restricted to zymogen activation and digestion. Indeed, serine proteases (trypsin and chymotrypsin) represent the most abundant digestive enzymes in fleas (Gaines et al, 1999;Dreher-Lesnick et al, 2010;Greene et al, 2015;Brown, 2019;Bland et al, 2020). These proteases convert proteins into smaller peptides and represent the most common digestive enzymes in blood-feeding arthropods (Bland et al, 2020).…”
Section: Serine Proteasesmentioning
confidence: 99%
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“…Drosophila and Galleria mellonella have recently been adapted as models for Y. pestisinsect interactions and have been used to show that the bacterial PhoPQ two-component gene regulatory system and the OxyR transcription factor mediate resistance to AMPs and ROS and are required for colonization of Drosophila and Galleria larvae, as well as the rat flea gut [8,17,18]. In studies of flea physiology and genetics, primarily with the cat flea, Ctenocephalides felis, many canonical insect responses to pathogens have been observed [7,[19][20][21][22]. Recent studies using cultured Drosophila cells and RNA interference in cat fleas indicate that R. typhi infection is moderated by antimicrobials generated by the immune deficiency (IMD) pathway, the major insect innate immune cascade that detects and responds to DAP-type peptidoglycan, common in Gram-negative bacteria [19].…”
Section: Plos Neglected Tropical Diseasesmentioning
confidence: 99%
“…Fleas are the major vector of other significant zoonotic bacterial diseases, such as murine typhus (Rickettsia typhi) and cat-scratch disease (Bartonella henselae) [9]. Nonetheless, little is known about the innate immune responses of Siphonapteran insects [10].…”
Section: Introductionmentioning
confidence: 99%