Immunity as the predominant factor determining metastasis by murine lymphomas

Davey, GM; Currie, G. A.; Alexander, Peter

doi:10.1038/bjc.1979.224

Cited by 16 publications

(8 citation statements)

References 11 publications

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“…Since the metastasizing fibrosarcoma line was also found to be less antigenic than the nonmetastasizing line, Alexander (1976a) suggested that the macrophages attracted into the latter were part of an immune response against the tumour cells which inhibited metastasis. Later observations that reduction of macrophage content (Wood & Gillespie, 1975) or suppression of the immune response (Davey et al, 1979) appeared to promote dissemination supported this hypothesis, at least for these tumours. In naturally occurring mammary tumours, however, we found macrophage content to be consistently low, ranging from 2 to 9o%, and thus there is no inverse correlation with spontaneous metastasis, which is infrequent (< 2%, Tarin & Price, 1979).…”

Section: Duration Of Macrophage Adherencementioning

confidence: 89%

Macrophage content and colony-forming potential in mouse mammary carcinomas

Nash¹,

Price²,

Tarin³

1981

Br J Cancer

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Summary.--The macrophage content of cell suspensions from naturally occurring mouse tumours has been assessed by the Fc-mediated phagocytosis assay, and the results compared with the individual tumour's capacity for spontaneous metastasis and with its pulmonary colonization potential after i.v. inoculation.It was found that these tumours differ in their properties from the transplantable fibrosarcomas studied previously by other investigators, in that the macrophage content of all the tumours was uniformly low, ranging from 2 to 9% (mean 4.2 + 1.80%)

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Section: Duration Of Macrophage Adherencementioning

confidence: 89%

Macrophage content and colony-forming potential in mouse mammary carcinomas

Nash¹,

Price²,

Tarin³

1981

Br J Cancer

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“…Changes which took place at the cell surface of these cells included carbohydrate side chains (23,24), lymphoid cell surface differentiation antigens (25), Fcr receptors (26), and receptors for Semliki-Forest Virus (27). Compared to Eb, ESbtype cells expressed more microvilli (18), showed increased shedding of surface antigens and vesicles (26,28), and had generally a higher morphological flexibility (deformability) (29) and a higher motility (30). ESb but not Eb cells had the ability to bind in vitro to normal adult cells from involved organs, namely liver (31) and lung (32).…”

Section: Eb/esb Tumor Model System: Etiology and General Characteristicsmentioning

confidence: 99%

“…The results revealed two conditions under which even the parental line Eb could give rise to internal metastases. One was upon inoculation via the intravenous route and the other upon s.c. inoculation into a host preirradiated with 500 rads (30,47). At a s.c. site in a normal host, Eb tumor cells grew progressively without establishing metastases.…”

Section: Spontaneous Variants From the Tumor And The Host" Detectionmentioning

confidence: 99%

Antigenic variation in cancer metastasis: immune escape versus immune control

et al. 1982

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Antigenic variation in cancer metastasis was observed in a syngeneic murine tumor system consisting of a low metastatic parental tumor line (derived from a methylcholanthrene-induced DBA/2 T lymphoma, Eb), a high metastatic spontaneous variant thereof (ESb), and a low metastatic 'revertant' from ESb (ESb-M). All three lines expressed tumor-associated transplantation antigens (TATA) which elicited specific T cell-mediated antitumor immune reactions in the host. The strongest host response was elicited upon intradermal inoculation. It could be followed by (a) the infiltration of the locally growing tumor by host cells, such as lymphocytes and macrophages, (b) the establishment of specific systemic antitumor immunity, (c) the generation of immune cells capable of transferring protective antitumor immunity into a normal syngeneic recipient, and (d) the generation of tumor specific cytotoxic T lymphocytes (CTL). Anti-TATA CTL were used as typing reagents to investigate the stability or variability in the TATA expression by cloned tumor cell lines. Antigenic variability in the TATA expression was seen under various conditions: (a) clone-dependent variation in the sensitivity to anti-TATA CTL lysis upon prolonged growth in tissue culture, (b) qualitative change in the TATA (TATA1 leads to TATA2) upon successive i.p. transplantation of the parental Eb tumor line and, (c) generation of TATA negative immune escape variants (TATA2 leads to TATA-) during metastasis formation from a s.c. site. The relative inefficiency of specific immunization procedures against ESb was found to be due to the effective generation of TATA negative variants by this highly metastatic tumor. The balance between immune control and immune escape could be influenced to the advantage of the host by some means, for instance optimizing the route of antitumor-immune sensitization or by infusion of allogeneic but H-2 identical antitumor-immune T cells. Such immune cells recognized the tumor via minor histocompatibility antigens and thus circumvented the need of TATA recognition. Finally, manipulations at the cell surface of the highly malignant ESb tumor such as those introduced in the ESb-M variant were found to dramatically effect its metastatic potential.

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“…The metastatic potential of induced and "dormant" metastases was of interest, since it has been suggested that metastases develop from subpopulations of cells of unique metastasizing ability, preexisting within primary tumours (Poste & Fidler,1 980 (Davey et al, 1979). Thus it is suggested thlat, for anaplastic tuimoturs in which the population is inherently highly clonogenic (i.e.…”

Section: Growth Rates Of Tumoursmentioning

confidence: 99%

Effect of cyclosporin A on the growth and spontaneous metastasis of syngeneic animal tumours

Eccles¹,

Heckford²,

Alexander³

1980

Br J Cancer

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Summary.-Cyclosporin A (Cy A), a novel immunosuppressive agent with apparently selective inhibitory effects on T lymphocytes and little myelotoxicity, was tested for its effects on a variety of syngeneic animal tumours including sarcomas, carcinomas and a T-cell lymphoma. Cy A, given orally or parenterally in repeated doses, had no effect on the growth rates of any of the tumours tested, but a highly significant effect on metastasis was seen in many cases. All the sarcomas examined in both rats and mice, and also the lymphoma, showed a marked increase in their metastases, in some cases even when administration of Cy A was delayed until after excision of the "primary" tumour implants. In contrast no effect of Cy A on metastasis was observed in animals bearing poorly immunogenic mammary or squamous-cell carcinomas. The metastases developing in Cy A-treated animals, when transplanted into normal syngeneic animals, showed no evidence of enhanced metastatic potential compared with their"parent" tumours.

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Immunity as the predominant factor determining metastasis by murine lymphomas

Cited by 16 publications

References 11 publications

Macrophage content and colony-forming potential in mouse mammary carcinomas

Macrophage content and colony-forming potential in mouse mammary carcinomas

Antigenic variation in cancer metastasis: immune escape versus immune control

Effect of cyclosporin A on the growth and spontaneous metastasis of syngeneic animal tumours

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