Immunity and Nutrition: The Right Balance in Inflammatory Bowel Disease

Tamburini, Bartolo; Manna, Marco Pio La; Barbera, Lidia La; Mohammadnezhad, Leila; Badami, Giusto Davide; Azgomi, Mojtaba Shekarkar; Dieli, Francesco; Caccamo, Nadia

doi:10.3390/cells11030455

Cited by 19 publications

(11 citation statements)

References 114 publications

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“…Numerous factors influence susceptibility to enterocolitis, and these factors are often reported to interact with one another. For example, congenital and adaptive immune system abnormalities, intestinal microbial imbalances, genetic factors, and environmental factors are considered as the leading causes of intestinal inflammation (Tamburini et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Dietary taurine effect on intestinal barrier function, colonic microbiota and metabolites in weanling piglets induced by LPS

Zhao,

Gai,

et al. 2023

Front. Microbiol.

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Diarrhea in piglets is one of the most important diseases and a significant cause of death in piglets. Preliminary studies have confirmed that taurine reduces the rate and index of diarrhea in piglets induced by LPS. However, there is still a lack of relevant information on the specific target and mechanism of action of taurine. Therefore, we investigated the effects of taurine on the growth and barrier functions of the intestine, microbiota composition, and metabolite composition of piglets induced by LPS. Eighteen male weaned piglets were randomly divided into the CON group (basal diet + standard saline injection), LPS group (basal diet + LPS-intraperitoneal injection), and TAU + LPS group (basal diet + 0.3% taurine + LPS-intraperitoneal injection). The results show that taurine significantly increased the ADG and decreased the F/G (p < 0.05) compared with the group of CON. The group of TAU + LPS significantly improved colonic villous damage (p < 0.05). The expression of ZO-1, Occludin and Claudin-1 genes and proteins were markedly up-regulated (p < 0.05). Based on 16s rRNA sequencing analysis, the relative abundance of Lactobacilluscae and Firmicutes in the colon was significantly higher in the LPS + TAU group compared to the LPS group (p < 0.05). Four metabolites were significantly higher and one metabolite was significantly lower in the TAU + LPS group compared to the LPS group (p < 0.01). The above results show that LPS disrupts intestinal microorganisms and metabolites in weaned piglets and affects intestinal barrier function. Preventive addition of taurine enhances beneficial microbiota, modulates intestinal metabolites, and strengthens the intestinal mechanical barrier. Therefore, taurine can be used as a feed additive to prevent intestinal damage by regulating intestinal microorganisms and metabolites.

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Section: Introductionmentioning

confidence: 99%

Dietary taurine effect on intestinal barrier function, colonic microbiota and metabolites in weanling piglets induced by LPS

Zhao,

Gai,

et al. 2023

Front. Microbiol.

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“…Since oxidative stress and inflammation are particularly important contributors to the development and progression of IBD [ 39 ], we assessed the in vitro antioxidant and anti-inflammatory capacities of CMC-AXT-NPs by measuring the levels of H 2 O 2 -induced oxidative stress and LPS-induced inflammation in Raw264.7 cells, respectively. As shown in Figure 3 A–C, the levels of TNF-α, IL-6, and IL-1β in the supernatant of cells stimulated with carrier, AXT, and CMC-AXT-NPs only were low and showed no significant difference compared to the non-LPS control group.…”

Section: Resultsmentioning

confidence: 99%

“…It is well-known that the immune dysfunction is the root cause of the dominating development of IBD [ 39 ]. In murine colitis models, there is an observed increase in the infiltration of monocytes and macrophages into the colon mucosa, which are responsible for the production of various inflammatory mediators [ 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment

Zhang,

et al. 2024

Molecules

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The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness of ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC treatment. The CMC-AXT-NPs were evaluated by appearance, morphology, particle size, ζ-potential, and encapsulation efficiency (EE). The results showed that CMC-AXT-NPs were nearly spherical in shape with a particle size of 34.5 nm and ζ-potential of −30.8 mV, and the EE of CMC-AXT-NPs was as high as 95.03%. The CMC-AXT-NPs exhibited preferable storage stability over time and well-controlled drug-release properties in simulated intestinal fluid. Additionally, in vitro studies revealed that CMC-AXT-NPs remarkably inhibited cytotoxicity induced by LPS and demonstrated superior antioxidant and anti-inflammatory abilities in Raw264.7 cells. Furthermore, CMC-AXT-NPs effectively alleviated clinical symptoms of colitis induced by dextran sulfate sodium salt (DSS), including maintaining body weight, inhibiting colon shortening, and reducing fecal bleeding. Importantly, CMC-AXT-NPs suppressed the expression of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β and ameliorated DSS-induced oxidative damage. Our results demonstrated the potential of CMC-modified nanoparticles as an oral delivery system and suggested these novel AXT nanoparticles could be a promising strategy for UC treatment.

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“…Diminished levels of butyrate and dietary fiber, in general, expedite catabolism at the mucosal level, leading to heightened intestinal permeability. This increased permeability renders the mucosa more susceptible to potential luminal pathogenic bacteria [ 80 , 81 ].…”

Section: Microbiota and Lactose Intolerancementioning

confidence: 99%

Cow’s Milk: A Benefit for Human Health? Omics Tools and Precision Nutrition for Lactose Intolerance Management

Pratelli,

Tamburini,

Badami

et al. 2024

Nutrients

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Cow’s milk (CM) is a healthy food consumed worldwide by individuals of all ages. Unfortunately, “lactase-deficient” individuals cannot digest milk’s main carbohydrate, lactose, depriving themselves of highly beneficial milk proteins like casein, lactoalbumin, and lactoglobulin due to lactose intolerance (LI), while other individuals develop allergies specifically against these proteins (CMPA). The management of these conditions differs, and an inappropriate diagnosis or treatment may have significant implications for the patients, especially if they are infants or very young children, resulting in unnecessary dietary restrictions or avoidable adverse reactions. Omics technologies play a pivotal role in elucidating the intricate interactions between nutrients and the human body, spanning from genetic factors to the microbiota profile and metabolites. This comprehensive approach enables the precise delineation and identification of distinct cohorts of individuals with specific dietary requirements, so that tailored nutrition strategies can be developed. This is what is called personalized nutrition or precision nutrition (PN), the area of nutrition that focuses on the effects of nutrients on the genome, proteome, and metabolome, promoting well-being and health, preventing diseases, reducing chronic disease incidence, and increasing life expectancy. Here, we report the opinion of the scientific community proposing to replace the “one size fits all” approach with tailor-made nutrition programs, designed by integrating nutrigenomic data together with clinical parameters and microbiota profiles, taking into account the individual lactose tolerance threshold and needs in terms of specific nutrients intake. This customized approach could help LI patients to improve their quality of life, overcoming depression or anxiety often resulting from the individual perception of this condition as different from a normal state.

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Immunity and Nutrition: The Right Balance in Inflammatory Bowel Disease

Cited by 19 publications

References 114 publications

Dietary taurine effect on intestinal barrier function, colonic microbiota and metabolites in weanling piglets induced by LPS

Dietary taurine effect on intestinal barrier function, colonic microbiota and metabolites in weanling piglets induced by LPS

Oral Delivery of Astaxanthin via Carboxymethyl Chitosan-Modified Nanoparticles for Ulcerative Colitis Treatment

Cow’s Milk: A Benefit for Human Health? Omics Tools and Precision Nutrition for Lactose Intolerance Management

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