Immunity against selected piscine flagellates

Woo, P. T. K.; Ardelli, Bernadette F.

doi:10.1016/j.dci.2013.07.006

Cited by 18 publications

(10 citation statements)

References 119 publications

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“…Regardless of these differences, in both trials, total circulating IgM increased over time in both experimental groups. The high level of total IgM of SUR fish in T1 before challenge (0 dpe) might be related to the greater age and size of this fish, but the higher levels of specific IgM of SUR fish in both trials ( [54]. Rainbow trout reexposed after 1 year to T. bryosalmonae responded with significantly increased circulating IgM + B cells and up-regulated secretory IgM expression in the posterior kidney, compared to unexposed and naïve-exposed fish already at 10 dpe [44].…”

Section: Discussionmentioning

confidence: 97%

Acquired protective immune response in a fish-myxozoan model encompasses specific antibodies and inflammation resolution

Picard‐Sánchez

Estensoro

Pozo

et al. 2019

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 97%

Acquired protective immune response in a fish-myxozoan model encompasses specific antibodies and inflammation resolution

Picard‐Sánchez

Estensoro

Pozo

et al. 2019

Fish & Shellfish Immunology

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“…, ; Corrales et al . ) and general immunological responses of the host to A. ocellatum by ELISA (Smith, Levy & Noga , ; Noga, Fan & Silphaduang ; Alvarez‐Pellitero, ; Woo & Ardelli ).…”

Section: Introductionmentioning

confidence: 99%

“…However, there are reports of high mortalities associated with mild infestations that could be associated with osmoregulatory impairment and secondary microbial infections due to severe epithelial damage (Noga 2012). Physiological information about the responses from the host to A. ocellatum infestation is limited, and is mainly available in some publications about immunohistochemical detection of antimicrobial protein expression in gills and skin (Colorni et al 2008;Noga et al 2009Noga et al , 2011Corrales et al 2010) and general immunological responses of the host to A. ocellatum by ELISA (Smith, Levy & Noga 1992, 1994Noga, Fan & Silphaduang 2002;Alvarez-Pellitero, 2008;Woo & Ardelli 2014).…”

Section: Introductionmentioning

confidence: 99%

Physiological responses of reared sea bream (Sparus aurata Linnaeus, 1758) to an Amyloodinium ocellatum outbreak

Moreira

Schrama

Soares

et al. 2017

Journal of Fish Diseases

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Amyloodiniosis represents a major bottleneck for semi-intensive aquaculture production in Southern Europe, causing extremely high mortalities. Amyloodinium ocellatum is a parasitic dinoflagellate that can infest almost all fish, crustacean and bivalves that live within its ecological range. Fish mortalities are usually attributed to anoxia, associated with serious gill hyperplasia, inflammation, haemorrhage and necrosis in heavy infestations; or with osmoregulatory impairment and secondary microbial infections due to severe epithelial damage in mild infestation. However, physiological information about the host responses to A. ocellatum infestation is scarce. In this work, we analysed the proteome of gilthead sea bream (Sparus aurata) plasma and relate it with haematological and immunological indicators, in order to enlighten the different physiological responses when exposed to an A. ocellatum outbreak. Using 2D-DIGE, immunological and haematological analysis and in response to the A. ocellatum contamination we have identified several proteins associated with acute-phase response, inflammation, lipid transport, homoeostasis, and osmoregulation, wound healing, neoplasia and iron transport. Overall, this preliminary study revealed that amyloodiniosis affects some fish functional pathways as revealed by the changes in the plasma proteome of S. aurata, and that the innate immunological system is not activated in the presence of the parasite.

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“…For example, the inhibitory effects of leptin on pituitary adrenocorticotropin hormone secretion and interrenal cell cortisol production in fish , and its ability to suppress the expression of key adrenocortex steroidogenic enzymes in mammals (Kruse et al 1998, Su et al 2012) likely contribute to the blunted stress response and reduced cortisol synthesis capacity of C. salmositica-infected rainbow trout (Madison et al 2013). Similarly, given the important roles of leptin in the regulation of hematopoiesis (Bennett et al 1996), angiogenesis (Anagnostoulis et al 2008), and the immune system (Carlton et al 2012, Mariano et al 2013), a promising avenue for future research in C. salmositicaand T. borreli-infected fish may be to explore the contribution of leptin to the regeneration of hematopoietic tissues during the chronic stage of infection and its effects on the innate and acquired immune responses that characterize these diseases (Woo & Ardelli 2014). Recent studies in fish have shown that leptin can function as a hyperglycemic factor (Baltzegar et al 2014) and stimulate metabolic rate (Dalman et al 2013).…”

Section: Figurementioning

confidence: 99%

Hypoxemia-induced leptin secretion: a mechanism for the control of food intake in diseased fish

MacDonald

Alderman

Krämer

et al. 2014

Journal of Endocrinology

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Leptin is a potent anorexigen, but little is known about the physiological conditions under which this cytokine regulates food intake in fish. In this study, we characterized the relationships between food intake, O 2 -carrying capacity, liver leptin-A1 (lep-a1) gene expression, and plasma leptin-A1 in rainbow trout infected with a pathogenic hemoflagellate, Cryptobia salmositica. As lep gene expression is hypoxia-sensitive and Cryptobia-infected fish are anemic, we hypothesized that Cryptobia-induced anorexia is mediated by leptin. A 14-week time course experiment revealed that Cryptobia-infected fish experience a transient 75% reduction in food intake, a sharp initial drop in hematocrit and hemoglobin levels followed by a partial recovery, a transient 17-fold increase in lep-a1 gene expression, and a sustained increase in plasma leptin-A1 levels. In the hypothalamus, peak anorexia was associated with decreases in mRNA levels of neuropeptide Y (npy) and cocaineand amphetamine-regulated transcript (cart), and increases in agouti-related protein (agrp) and pro-opiomelanocortin A2 (pomc). In contrast, in non-infected fish pair-fed to infected animals, lep-a1 gene expression and plasma levels did not differ from those of non-infected satiated fish. Pair-fed fish were also characterized by increases in hypothalamic npy and agrp, no changes in pomc-a2, and a reduction in cart mRNA expression. Finally, peak infection was characterized by a significant positive correlation between O 2 -carrying capacity and food intake. These findings show that hypoxemia, and not feed restriction, stimulates leptin-A1 secretion in Cryptobia-infected rainbow trout and suggest that leptin contributes to anorexia by inhibiting hypothalamic npy and stimulating pomc-a2.

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Immunity against selected piscine flagellates

Cited by 18 publications

References 119 publications

Acquired protective immune response in a fish-myxozoan model encompasses specific antibodies and inflammation resolution

Acquired protective immune response in a fish-myxozoan model encompasses specific antibodies and inflammation resolution

Physiological responses of reared sea bream (Sparus aurata Linnaeus, 1758) to an Amyloodinium ocellatum outbreak

Hypoxemia-induced leptin secretion: a mechanism for the control of food intake in diseased fish

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