Immunisation of guinea pigs and cattle against ticks

Allen, John R.; Humphreys, Susie

doi:10.1038/280491a0

Cited by 152 publications

(61 citation statements)

References 7 publications

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“…Our results confirm the findings of Allen and Humphreys (1979) who achieved greater success in immunizing guinea-pigs and cattle with tick extracts derived from partly fed than from unfed females of Dermacentor andersoni. This is likely to be due to the fact that partial feeding of ticks increases the number of gut cells to the maximum .…”

Section: Z7supporting

confidence: 81%

“…These results are in agreement with the findings of Kumar (1990) using Hyalomma anatolicum ticks fed on cattle immunized with gut antigens. Similar findings were observed by other workers using D. andersoni (Allen and Humphreys, 1979;Ackerman et al, 1980). A. americanum (Wikel et al, 1987) and B. microplus (Willadsen et al, 1989), when fed on animals immunized with various tick antigens.…”

Section: Z7supporting

confidence: 79%

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Artificial immunization of rabbits with Hyalomma dromedarii tick-derived midgut antigen

Kumar

1995

Exp Appl Acarol

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New Zealand white rabbits were immunized with partly fed Hyalomma dromedarii tick-derived midgut concealed antigens (supernate and pellet fractions) and Freund's complete adjuvant (FCA). The rabbits received three inoculations subcutaneously on days 0, 14 and 21 at a dose rate of 1 mg antigen per animal. The effects of the immunity induced was determined by infesting the rabbits with adult H. dromedarii ticks. In immunized rabbits a significant reduction in tick yield, engorgement weight, oviposition period, egg mass weight and percentage of egg hatchability was found. The gut supernatant antigen fraction induced the best protection in terms of reduced feeding and reproductive performance of the ticks.

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Section: Z7supporting

confidence: 81%

Section: Z7supporting

confidence: 79%

Artificial immunization of rabbits with Hyalomma dromedarii tick-derived midgut antigen

Kumar

1995

Exp Appl Acarol

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“…Western blot analysis revealed that the glycoproteins used in the present study elicited a specific IgG response in immunized animals, while sera from animals of group B did not recognize the antigens. The idea of developing immunoprophylactic measures against multi-tick infestations on crossbred animals was based on the concept that ticks feeding on appropriately immunized hosts might ingest antibodies specific for a target antigen(s) within the tick, producing a deleterious effect on their feeding and reproductive performances (Allen and Humphreys 1979;Johnston et al 1986;Pruett 1999). In the case H. a. anatolicum, we previously reported immunoprotective larval (39 kDa), nymphal (39 kDa) and gut-specific larval glycoproteins (34 kDa) as candidate vaccine molecules.…”

Section: Discussionmentioning

confidence: 99%

Assessment of duration of immunity in crossbred cattle immunized with glycoproteins isolated from Hyalomma anatolicum anatolicum and Boophilus microplus

2005

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To develop immunoprophylactic measures against multi-tick infestation, two glycoproteins of 34 and 29 kDa were isolated from the larvae of Hyalomma anatolicum anatolicum and Boophilus microplus, respectively, and assessed for their efficacy against experimental challenge infestations. The synergistic effect of the antigens in the presence of incomplete Freund's adjuvant was found to confer protection (DT%) in animals against 56.48% of larvae and 52% of adults of H. a. anatolicum, while the effect was 40% against adults of B. microplus. The efficacy (E%) of the antigens in combination against larvae and adults of H. a. anatolicum was calculated as 70% and 64.3%, respectively, and 63% against adults of B. microplus. A direct correlation between anti-glycoprotein antibody response and protection against infestation was observed. Western blot analysis detected specific antigen in the sera of animals of group A. The antigens in combination with incomplete Freund's adjuvant could protect animals from H. a. anatolicum and B. microplus infestations for at least 30 weeks. The possibility of employing the vaccination strategy in Indian conditions is discussed.

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“…In addition, these methods may have a short-lived effect owing to development of tick resistance to acaricides (Drummond, 1970). Induction of host immunity to tick infestation represents an alternative approach to the control of ticks and the pathogens they transmit (Allen & Humphreys, 1979;Wikel, 1980Wikel, , 1981.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Host Resistance to Tick Infestation on the Transmission of Thogoto Virus by Ticks

Jones

Nuttall

1990

Journal of General Virology

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Immunisation of guinea pigs and cattle against ticks

Cited by 152 publications

References 7 publications

Artificial immunization of rabbits with Hyalomma dromedarii tick-derived midgut antigen

Artificial immunization of rabbits with Hyalomma dromedarii tick-derived midgut antigen

Assessment of duration of immunity in crossbred cattle immunized with glycoproteins isolated from Hyalomma anatolicum anatolicum and Boophilus microplus

The Effect of Host Resistance to Tick Infestation on the Transmission of Thogoto Virus by Ticks

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