Immunhistologische Analyse der chronisch-obstruktiven Sialadenitis - I. Veränderungen in der Expression von Antigenen des Haupthistokompatibilitätskomplexes*

Möller, P.; Born, I. A.; Momburg, Frank; Moldenhauer, Gerhard; Maier, H.; Weidauer, H.; Otto, Herwart F.

doi:10.1055/s-2007-998815

Cited by 4 publications

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References 2 publications

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“…The microtopographic relation with chronic inflammation corresponds to our observations in ileitis terminalis (Koretz et al, 1987) and non-specific colitis (Degener et al, 1988), and consequently suggests a sequential induction of these antigens in the above-mentioned order, most likely by factors released from the cellular infiltrate. The association of class-I1 antigen induction with ductectasia is in accordance with what we found in obstructive sialadenitis (Moller et al, 1986) and might be interpreted as a consequence of chronic congestion. When this information is applied to the neoplastic state, a breast carcinoma expressing class-I1 products and/or Ii in a subset of its neoplastic population has hence to be regarded as "partially induced" and not as a tumor featuring a "partial loss" or "reduction" of this class of antigens, as had been characterized by Walker (1987, 1988).…”

Section: Discussionsupporting

confidence: 90%

Correlation of HLA‐D/Ii antigen expression in breast carcinoma with local lymphohistiocytic infiltration reveals considerable dysregulation in a subset of tumors

Koretz

Moldenhauer

Majdic

et al. 1989

Intl Journal of Cancer

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Non-neoplastic mammary glands and 203 carcinomas of the breast were examined immunohistochemically for expression of HLA-DR, -DP, and -DQ molecules and the HLA-D-associated invariant chain (Ii). According to the reaction of normal breast epithelium in the course of chronic inflammation, these antigens were found to be induced in 120 carcinomas. In 106 of these the order was Ii greater than or equal to HLA-DR greater than or equal to HLA-DP greater than or equal to HLA-DQ. The extent of induction of these sequentially expressed antigens correlated with the density of local lymphohistiocytic infiltration (Ii: p = 0.003; HLA-DR: p = 0.0005; HLA-DP: p = 0.0000005; HLA-DQ: p = 0.01). Therefore, Ii/HLA-D antigen expression of carcinoma cells in local association with inflammation was regarded as an adequate reaction. The presence of these antigens in the absence of inflammation was regarded as "inadequate hyper-expression", and was found in 14 cases involving Ii, in 8 involving HLA-DR, and in 1 case each involving -DP and -DQ molecules. In contrast, 20 cases expressed minimal/no Ii despite heavy inflammatory infiltration. This "inadequate hypo-expression" was also found in 25 cases involving HLA-DR, in 30 involving -DP and in 40 involving -DQ determinants. Combining the 2 variants showed that at least 54 cases (26.6%) were characterized as being dysregulated. "Adequate vs. inadequate Ii/HLA-D antigen expression" did not correlate with tumor grading and might therefore be an independent parameter.

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Section: Discussionsupporting

confidence: 90%

Correlation of HLA‐D/Ii antigen expression in breast carcinoma with local lymphohistiocytic infiltration reveals considerable dysregulation in a subset of tumors

Koretz

Moldenhauer

Majdic

et al. 1989

Intl Journal of Cancer

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“…In the course of the disease, ductal cells show changes in the expression of the major histocompatibility complex (MHC) antigens with increased expression of HLA‐A–HLA‐C. In addition, epithelial HLA‐DR expression is significantly enhanced in intercalated ducts, compared to normal controls (15, 16), from which it can be assumed that there is a close relationship between ductal cells and lymphocytes. An exact observation of the morphological changes during the different stages of chronic obstructive sialadenitis revealed an initial increase in lymphocytic infiltration and fibrosis occurring adjacent to ductal cells.…”

Section: Discussionmentioning

confidence: 99%