Abstract:Fc-fusion recombinant factor VIII product (rFVIIIFc), an extended half-life product, lowers an antigenicity against coagulation factor protein by increasing the regulatory T cell and indicates the tolerance is induced and promoted in animal models. Therefore, immune tolerance induction (ITI) is expecting its efficacy for haemophilia patients with inhibitor. It has been reported that some cases who underwent the ITI using rFVIIIFc showed a shorter duration than the use of conventional product until their inhibi… Show more
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