Immune thrombocytopenia: what can the systems biology and systems physiology offer?

Abstract

Immune thrombocytopenia (ITP) is an acquired bleeding disorder of autoimmune pathophysiology. The causes of ITP could be related to other pathology (viral, bacterial, or systemic), or ITP could develop without any apparent reason. While the immune system dysregulation mechanisms in ITP were described, its etiology remains unclear. Moreover, all existing treatment approaches are not specific for ITP, and its action is highly patient-specific.Here we describe recent findings in the origins and development of ITP and discuss novel experimental and theoretical approaches to diagnosing ITP and predicting therapy effects.

Systems Biology and Physiology Reports in 2021: a yearly report

“…After a year of development, SBPReports boasts a highly professional and dedicated editorial board formed by experts in the systems biology field from Belarus, Canada, China, India, Russia, UK and USA. The three major sections of the edition are related to the three major levels of understanding of the biological systems: molecular [1,2], cellular [3,4], and organism [5,6] levels. The papers published in the four issues during this year include original articles [1,2,4,6], reviews [5,[7][8][9], and methodological studies [10,11].…”

“…The three major sections of the edition are related to the three major levels of understanding of the biological systems: molecular [1,2], cellular [3,4], and organism [5,6] levels. The papers published in the four issues during this year include original articles [1,2,4,6], reviews [5,[7][8][9], and methodological studies [10,11]. In addition, two large abstract collections Systems Biology and Systems Physiology Congress 2021 and International Congress devoted to the Memory of the Founders of Biophysics Department of Physics Faculty of Lomonosov Moscow State Universityprofessor L.A. Blumenfeld and professor S.E.…”