Immune thrombocytopenia in adults: An update

Abstract

Immune thrombocytopenia (ITP) in adults is a chronic disease resulting from increased platelet destruction and impaired platelet production. Splenectomy remains the most effective and durable treatment in cases that are refractory to first-line therapy, but its use has declined because of the availability of alternate medical therapy, the associated risk of infection, and concern for surgery-related complications. Rituximab (Rituxan) may be an effective alternative but carries the risk of immunosuppression.

RETRACTED: <i>Aspects of Viral Involvement in Chronic Immune Thrombocytopenic Purpura</i>

“…This thrombocytopenia occurs within a mechanism of early hyper destruction of blood platelets caused by some anti-platelet autoantibodies or by some immune complex platelet membrane which causes their absorption by the macrophage [3] [4]. The short lifetime of platelets is the consequence of an autoimmune mechanism.…”

Therapeutic Uses of <i>Lycium barbarum</i> Polysaccharides on Idiopathic Thrombocytopenic Purpura Mice via Inhibition of Oxidative Stress

“…ITP is an autoimmune condition with antibodies detectable against several platelet surface antigens [6]. Corticosteroids, anti-D immunoglobulin, intravenous immunoglobulin, or immunosuppressive drugs were often used to cure the patients with very low counts or significant bleeding [7]. ITP occurs when certain immune system cells produce antibodies against platelets.…”

Acquired Amegakaryocytic Thrombocytopenia in a Child: A Very Rare Case

“…AATP is a disease of hematopoietic stem cells manifest with amegakaryocytic thrombocytopenia which subsequently may progress into aplastic anaemia or myelodysplastic syndrome [3]. It is an immune-mediated disorder including both cell-mediated and humoral immunity.…”