Immune system as a new therapeutic target for antibiotics

Kwiatkowska, Brygida; Maślińska, Maria; Przygodzka, Małgorzata; Dmowska-Chalaba, Joanna; Dąbrowska, Justyna; Sikorska-Siudek, Katarzyna

doi:10.4236/abb.2013.44a013

Cited by 10 publications

(12 citation statements)

References 41 publications

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“…Regarding our PP meshes, ampicillin-loaded meshes both untreated and F plasmatreated significantly stimulated in vitro NIH/3T3 migration exceeding that of the rest of surfaces, which may be related to the higher amount of ampicillin released into the medium by these two meshes compared with the ampicillin-loaded PEG-treated mesh. Dose-dependent effects of beta-lactams on several biological functions of eukariote cells have long been known [83], including the activation of chemotaxis in inflammatory cells [84,85]. Again, F-plasma treated ampicillin-loaded PEG-treated PP meshes (F-3.5s+AMP+PEG) did not elicit the same effect, but maintained the slight migratory effects observed with the untreated PP fibres leading us to conclude that the combination of these three treatments allowed maintaining the same chemotactic behavior of the PP fibres, thus justifying the relevance of the entire conditioning of the PP meshes by plasma processing.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization

et al. 2015

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Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success.

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Section: Discussionmentioning

confidence: 99%

Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization

et al. 2015

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“…This includes finding for them new applications beyond the infection treatment such as in organ transplantation, invasive cardiology and treatment of autoimmune diseases e.g rheumatoid arthritis or asthma. Yet, undoubtedly, this line of drug development needs further research [139].…”

Section: Discussionmentioning

confidence: 99%

“…Immunomodulatory effect of macrolides has been documented in the treatment of rheumatoid arthritis (RA), still's disease in adults and inflammatory bowel diseases as well as in adjuvant arthritis [139] [140]. Therefore in the battle against rapidly emerging bacterial resistance we can no longer rely entirely on the discovery of new antibiotics; we must also pursue rational approaches to the use of older antibiotics [2] [8] [52].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection

El-Banna¹,

El-Aziz²,

El-Mahdy³

et al. 2015

JBM

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There is growing interest in re-evaluation of older antibiotics with the wide spread of pathogen resistance, especially gram negative bacteria, which impair treatment of some infections. In contrast various studies have reported that some antibiotics have efficacy in clearing resistant bacterial infections. On account of that it was interesting to evaluate the efficacy of erythromycin, chloramphenicol and/or tenoxicam in curing and/or relieving wound infection of highly resistant Escherichia coli and investigate the possible mechanisms beyond their antibacterial activity. This was achieved through evaluating highly resistant E. coli strains in vitro using agar dilution and in vivo rat models of E. coli infected wound and acute inflammation by carrageenin, where possible mechanisms were evaluated through measuring immunological mediators and histopathological examination. This study revealed that in vivo, erythromycin alone or in combination with tenoxicam significantly improved the healing of infected skin wounds with E. coli irresspective of resistancy in vitro. In addition to the improvement of immunological mediators involved in inflammatory reaction, oxidative stress and in cytokines expression as response to the bacterial infection in vivo. On the other hand chloramphenicol neither alone nor in combination with tenoxicam, achieved any significant effect. Tenoxicam didn't show antimicrobial activity alone nor in combination with tested antibiotics in vitro, but it has shown synergestic activity in combination with tested antibiotics in vivo. Thus we concluded that immunomodulatory activity of erythromycin through anti-inflammatory and antioxidant effects was the possible mechanisms by which this antibiotic had healed infection with resistant E. coli in vivo, despite its resistancy to this antibiotic in vitro.

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“…Ofloxacin and ciprofloxacin reduce the synthesis of TNF-α at concentrations below 25 mg L −1 . Grapafloxacin inhibits IL-8 production in TNF-α stimulated cells [68]. In vivo, ciprofloxacin and trovafloxacin were able to rescue mice injected with a lethal dose of LPS by decreasing serum IL-6 and TNF-α levels [69].…”

Section: Quinolones/fluoroquinolonesmentioning

confidence: 99%

Immunomodulation by antibiotics

Blum¹,

Schiffmann²,

Parnham³

2018

Fighting Antimicrobial Resistance

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Immune system as a new therapeutic target for antibiotics

Cited by 10 publications

References 41 publications

Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization

Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization

Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection

Immunomodulation by antibiotics

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Immune system as a new therapeutic target for antibiotics

Cited by 10 publications

References 41 publications

Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization

Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization

Efficacy of Some Antibiotics in Curing Resistant &lt;i&gt;Escherichia coli&lt;/i&gt; Infection

Immunomodulation by antibiotics

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Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection