Immune system and regulation of regeneration

Германович, Юшков Борис

doi:10.20538/1682-0363-2017-4-94-105

Cited by 10 publications

(3 citation statements)

References 47 publications

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“…Персистенція збудника, некроз тканин у вогнищі запалення та обумовлена цим інтоксикація підвищують навантаження на імунну систему і викликають порушення її функціонування. Це призводить до розвитку вторинної імунної недостатності, що своєю чергою впливає на перебіг хірургічної інфекції та патологічного процесу в зоні ураження [9,10].…”

Section: вступunclassified

The Dynamics of Immunological Indices in Patients with Posttraumatic Osteomyelitis and Trophic Disoders of the Shin Tissues

Dekhtiarenko

Hrytsai

Tsokalo

2020

HOTP

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Summary. The article deals with the study of immune status of patients with osteomyelitis and trophic disorders of the shin tissues. Objective: to evaluate the immune status of patients with shin-bone osteomyelitis and distrophic processes, and to study dynamics of immunological indices after surgical interventions (clearing and reconstructive restoring surgeries). Materials and Methods. The immune status of 52 patients with posttraumatic osteomyelitis and trophic disorders of the shin tissues was studied. Clinical, immunological, and statistical research methods were used. Results. The study revealed changes in immune defence and in trophic processes in tissues (bones, skin, and muscles) of the damaged extremity. Thus, the presence of changes in the immune status was established: a decrease in the number of T-lymphocytes, T-helpers, cytotoxic T-lymphocytes, as well as changes in the humoral immune system – a decrease in immunoglobulins M and G levels and an increace in the level of circulating immune complexes. Conclusions. Changes in systemic immunity and local trophic disorders revealed in patients mutually aggravate the course of the pathological process and complicate its elimination.

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Section: вступunclassified

The Dynamics of Immunological Indices in Patients with Posttraumatic Osteomyelitis and Trophic Disoders of the Shin Tissues

Dekhtiarenko

Hrytsai

Tsokalo

2020

HOTP

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“…It is worth noting that an important role in the regulation of regenerative processes in the body belongs to the immune system, all elements of which are actively involved in restoring the structure and function of cells of the damaged tissue. In this regard, the question arises about the expediency of using immunological drugs to impact the reparative processes in the affected organs and tissues [ 10 , 18 ]. The scientific literature describes studies of the positive effect of various immunosuppressants on liver regeneration.…”

Section: Introductionmentioning

confidence: 99%

Aminodihydrophthalazinedione Sodium Transdermal Therapeutic System Specific Activity on an ExperimentalModel of Extensive Liver Resection

Кузнецова

Salomatina

Kuryleva

et al. 2023

Life

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Previously, the authors showed that the application of the aminodihydrophthalazinedione sodium (ADPS) immunomodulator transdermal therapeutic system (TTS) to laboratory animals provides bioavailability analogous to the intramuscular administration of this drug at the same dose. At the same time, its maximum blood concentration is significantly reduced, and the retention time of the drug in the body is increased more than 10-fold, which can contribute to prolonging the drug effect. The aim of the work was to identify a possible positive effect of the transdermal administration of the ADPS immunomodulator on reparative liver regeneration on an experimental model of extensive liver resection (ELR). It has been shown that at a period of 48 h after ELR, the percutaneous administration of the immunomodulator has a pronounced stimulating effect on the mitotic activity of rat liver cells; by 72 h after ELR, an accelerated rate of recovery of hepatic homeostasis in the body was observed in laboratory animals in groups with the application of the ADPS TTS versus the control group.

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“…Regeneration of the damaged bronchial and alveolar epithelial barrier is critical for survival and recovery of both respiratory and metabolic functions of the lung [9][10][11][12][13][14]. At the same time, cells of the immune system play an important role in the recovery processes [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Influence of Cd68 Positive Cells on the Processes of Proliferation and Apoptosis in the Structures of the Respiratory System

Protsko,

Shishkina,

Naumova

et al. 2023

ArveMED

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Aim: To study the influence of macrophages or CD68 positive cells on the processes of proliferation and apoptosis in the respiratory system. Materials and Methods: Experimental modeling of chronic hypoxic hypoxia in combination with inhalation of natural gas was carried out on 133 outbred male rats. Hypoxia was simulated using special seed chambers and natural gas from the Astrakhanskoye Conventional Gas Field at a concentration of 3 mg/m3. The animals were placed under these conditions four hours a day for five days a week for four months. The animals were removed once a month - after 30, 60, 90 and 120 days. The activity of proliferation and apoptosis processes was studied by immunohistochemical method, followed by analysis of the expression of the proliferation marker Ki67, the apoptosis marker p53. The morphofunctional activity of macrophages was determined by the distribution of CD68 positive cells in structural components of respiratory system and the cytokine content in arterial blood taken from the abdominal aorta, that is, at the exit from lungs. Results: With the increase of the chronic experiment duration, the formation of two types of multidirectional morphological changes was revealed: thinning and stretching of the interalveolar septa, an increase in the volume of the alveoli in the peripheral parts of the lungs, and thickening of the interalveolar septa due to increased blood supply and edema-swelling in the early stages and proliferation of fibrous connective tissue in later periods; whereas the diameter and volume of the alveoli became smaller. Under chronic hypoxia combined with the action of natural gas, in all studied structures of the respiratory system there was an increase in the activity of CD68 positive cells. This is manifested by an increase in their number and activation of spontaneous and induced production of the pro-inflammatory cytokine TNFα. Besides, in areas of the lungs with changes in the type of atelectasis, an increase in the expression of the proliferation marker Ki67 and the apoptosis marker p53 was revealed. The latter is most likely associated with a deterioration in blood supply and oxygenation of these areas and the migration of leukocyte and fibroblast cells here, followed by their proliferation and formation pulmonary fibrosis. In areas with emphysematous changes, a decrease in the content of Ki67 positive cells was revealed with a simultaneous increase in the number of p53 positive cells. Conclusion: Thus, it is possible to determine a direct relationship between the increase in the morphofunctional activity of CD68 positive cells and the intensity of proliferation and apoptosis processes in the structural components of the respiratory system under chronic hypoxia combined with natural gas inhalation.

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Immune system and regulation of regeneration

Cited by 10 publications

References 47 publications

The Dynamics of Immunological Indices in Patients with Posttraumatic Osteomyelitis and Trophic Disoders of the Shin Tissues

The Dynamics of Immunological Indices in Patients with Posttraumatic Osteomyelitis and Trophic Disoders of the Shin Tissues

Aminodihydrophthalazinedione Sodium Transdermal Therapeutic System Specific Activity on an ExperimentalModel of Extensive Liver Resection

Influence of Cd68 Positive Cells on the Processes of Proliferation and Apoptosis in the Structures of the Respiratory System

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