Immune status in patients with Meniere's disease

Evans, Kelly; Baldwin, David L.; Bainbridge, D. R.; Morrison, A. W.

doi:10.1007/bf00464632

Cited by 40 publications

(31 citation statements)

References 18 publications

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“…thyroid dysfunction [Brenner et al, 2004], increased microsomal thyroid antibodies [Evans et al, 1988], and a significant level of autoantibodies (overall antithyroid antibody positivity) [Fattori et al, 2008]. In a recent report a significant association between MD and autoantibody increments, e.g.…”

Section: Introductionmentioning

confidence: 97%

Experimental Hyperactivity of the Endolymphatic Sac

Friis

Thomsen²,

Poulsen³

et al. 2013

Audiol Neurotol

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Injury to the endolymphatic sac may play an important role in the pathogenesis of Ménière’s disease, an inner ear disorder characterized by hearing loss, tinnitus and attacks of vertigo. Isoimmunization of 16 inbred Lewis rats with a crude endolymphatic sac extract and complete Freund’s adjuvant induced hyperactivity of the endolymphatic sac. One group of rats was immunized by a single dose whereas a second group was immunized twice. Control animals were injected with Freund’s adjuvant in saline only. Serum was collected from all rats by the end of the study and harvested autoantibodies were tested by immunohistochemistry. The endolymphatic sacs were investigated by transmission electron microscopy. Endolymphatic sac stimulation was observed in all immunized rats. Based on detailed ultrastructural observations, the degree of reactivity seemed proportional to the number of injections and the extent of immunization. Moreover, the ribosome-rich cells seemed hyperactive with an extravagant content of intracellular components: numerous rough endoplasmic reticulum and free ribosomes, morphological signs of extensive endo- and exocytosis, vesicles of material with a density similar to the homogeneous substance of which many were observed to fuse with primary lysozymes. Basolateral foldings were numerous and in the subepithelial capillaries formation of multiple and apposing fenestrations were observed. No endolymphatic sac stimulation was observed in the control animals. Specific ribosome-rich cell alterations identical to those present in the endolymphatic sac of Ménière’s disease were observed 21 days after the first immunization. The observations suggest that either an autoantigen or a trophic factor, capable of inducing a hyperactivity of the ribosome-rich cells and an imbalance of the homogeneous substance metabolism, exists in the endolymphatic sac of the rat.

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Section: Introductionmentioning

confidence: 97%

Experimental Hyperactivity of the Endolymphatic Sac

Friis

Thomsen²,

Poulsen³

et al. 2013

Audiol Neurotol

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“…The possible association between AITD and MD has been postulated since over 30 years, although it is still a controversial issue. At the beginning of the 1980s, Kinney [1980] and Meyerhoff [1981] excluded a relationship between thyroid dysfunction and MD [Kinney, 1980;Meyerhoff et al, 1981]; however, Evans et al [1988] showed that antithyroid microsome antibodies occurred in 17% of 150 MD patients [Evans et al, 1988] and this association was recently confirmed [Brenner et al, 2004;Fattori et al, 2008]. Interestingly, Evans et al [1988] showed 2 or more positive serum autoantibody titers in 9.3% of MD patients, the commonest being antinuclear autoantibody (23.3% of patients).…”

Section: Introductionmentioning

confidence: 99%

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

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Objective/Hypothesis: The aim of this prospective study is to evaluate the possible association between Ménière’s disease (MD) and autoantibodies. Methods: Fifty-five patients with definite MD (51 unilateral and 4 bilateral) were matched with 55 patients with unilateral vestibular paresis without cochlear involvement and 55 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, anti-TSH receptor antibody, antithyroperoxidase antibody, antithyroglobulin antibody and of antibodies to non-organ-specific antigens, namely antinuclear antibodies, antibodies to extractable nuclear antigens and antineutrophilic cytoplasmic antibodies. Results: Thirty-three subjects (60%) of the MD group had 1 or more elevated serum autoantibody levels, both organ and non-organ specific; 16 patients (29.1%) with unilateral vestibular paresis had 1 or more elevated serum autoantibody levels, while 13 healthy subjects (23.6%) had 1 or more elevated serum autoantibody levels. Conclusions: Based on our data we speculate that there is a more than a chance association between MD and ‘autoimmunity’, thus suggesting a hypothetical role of the immune system in MD pathogenesis. In other words, a pathogenetic role of an ‘immune dysregulation’ in MD patients can be hypothesized.

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“…Many studies have reported the high frequency of nonspecific autoantibodies in 50-70% of the patients with MD, with the anti-nuclear antibodies being the most common [19,20]. Since autoantibodies are frequently detected in chronic inflammatory disorders with infectious origin, the high frequency of these autoantibodies in MD suggests a secondary autoimmune process induced by a persisting infectious agent.…”

Section: Discussionmentioning

confidence: 99%

Expression of A, B, C and DR antigens in definite Meniere's disease in a Spanish population

López-Escámez

López-Nevot

Cortes

et al. 2002

Eur Arch Otorhinolaryngol

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To analyze the associations of HLA class I and II antigens in patients with Meniere's disease (MD) in southern Spain, 54 patients with definite MD according to the diagnostic scale of the AAO-HNS were compared with 534 normal controls in a prospective multicenter study. We performed a serological typing for A, B, C and DR specificities of the major histocompatibility complex and allele-specific amplification for HLA-DRB1. No differences were found in the distribution of class I antigens or DR antigens in patients with definite MD when they were compared with the control group. Our results suggest that HLA antigens do not determine an increased susceptibility to develop MD. © Springer-Verlag 2002 rected by multiplying the total number of antigen comparisons [10].

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Immune status in patients with Meniere's disease

Cited by 40 publications

References 18 publications

Experimental Hyperactivity of the Endolymphatic Sac

Experimental Hyperactivity of the Endolymphatic Sac

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Expression of A, B, C and DR antigens in definite Meniere's disease in a Spanish population

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