Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence

Бараннік, Н. Г.; Varzhapetyan, S. D.; Sidoryako, A. V.; Karabinova, Yu. S.

doi:10.14739/2310-1210.2016.1.63647

Cited by 2 publications

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“…Питанням оптимізації хірургічного та медикаментозного лікування одонтогенних флегмон щелепно-лицевої локалізації протягом тривалого часу займаються, як вітчизняні, так і закордонні дослідники та клініцисти. Позитивні результати щодо нормалізації імунологічної реактивності організму пацієнта було доведено за умов використання препаратів групи адаптогенів, які мають імуномодулюючу (нормалізуючу) дію незалежно від типу реагування організму на інфекційний процес [5,6]. Добре себе зарекомендувало використання антиоксидантів з метою Актуальні проблеми сучасної медицини корекції метаболічних порушень та підвищення антиоксидантного захисту організму, яке обумовлено підвищеним рівень вільно-радикального окислення за умов гнійно-запальних процесів [7].…”

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Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Kiptilyi,

Yatsenko,

Lychman

et al. 2023

Act. Probl. of the Modern Med.

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A large cohort of scientists is dealing with the issue of improving the treatment of maxillofacial odontogenic phlegmons. The course of these diseases is impacted by a significant number of factors, one of which is ishemic heart disease. Quercetin is a powerful antioxidant with a pronounced antioxidant effect. The use of 2-ethyl-6-methyl-3-hydroxypyridine succinate leads to increased oxidation of components, that is, to a synergistic antioxidant effect. The purpose of this study is to enhance the therapy of odontogenic phlegmons of maxillofacial area in patients with ishemic heart disease through the combined use of drugs with antioxidant, antihypoxant and angioprotective effects. Materials and methods. 80 patients with odontogenic phlegmon of maxillofacial area were examined. The participants were categorized into the following groups: Group 1 received parenteral quercetin, Group 2 received a combination of quercetin and intravenous administration of 2-ethyl-6-methyl-3-hydroxypyridine succinate, Group 3 received standard treatment (20 individuals), and Group 4 (control) comprised individuals without concomitant pathology who received the treatment according to a standard protocol (20 patients). To analyze the state of free radical oxidation processes in blood serum, the content of diene conjugates was studied. Results. The level of diene conjugates was increased when compared to the control group by 93.2%, 95.0% and 96.2% for the 1st, 2nd and 3rd clinical groups, respectively. On the third day of observation, patients with coronary heart disease displayed an increase in the studied indicator by 99.1%, 100.6%, and 97.8%, respectively, compared to the controls. After 5 days, in all four clinical groups, there was a decrease in diene conjugates content in blood serum compared to the previous observation period by 6.9%, 8.2%, 5.3% and 11.8%, respectively. A tendency to a gradual decrease in the content of diene conjugates was observed on the 7th day of observation in all groups by 5.5%, 6.8%, 4.2% and 11.8%, respectively, with its increase relative to the control by 112.9 %, 108.7% and 118.2% for the 1st, 2nd and 3rd clinical groups, respectively. On the 9th day of observation, a decrease in DC content by 2.7% was found only in patients of the 2nd clinical group. At the final follow-up period, a decrease in this marker was noted in all studied clinical groups relative to the previous follow-up period by 5.1%, 6.9%, 2.3%, and 9.7%, respectively. Conclusion: Under the combined administration of quercetin and 2-ethyl-6-methyl-3-hydroxypyridine succinate alongside a standard treatment protocol, the reduction in the level of diene conjugates in blood serum was most significant among patients with coronary heart disease, particularly in the later stages following surgical treatment.

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Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Kiptilyi,

Yatsenko,

Lychman

et al. 2023

Act. Probl. of the Modern Med.

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State of local immune in phegmon of the maxillofacial region and neck on the background local photodynamic therapy

Cherniak

Harelik

Haretskaya

et al. 2023

jour

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Objective. To study the effect of local photodynamic therapy (PDT) on local immunity in patients with maxillofacial region and neck phlegmonas.Materials and methods. The study included 62 patients with phlegmon of the maxillofacial region and neck. Two groups of patients were formed. Patients of the 1st group were treated locally according to the traditional methods. Patients of the second group additionally underwent local PDT on the background of the complex of traditional therapeutic measures.Results. Under the influence of local PDT with the preparation «Fotolon» in patients with maxillofacial region phlegmonomas in the postoperative wound we observed activation of phagocytosis, an increase in the population of CD3 + T-lymphocytes, subpopulation CD4 + T-helper, immunoregulatory index (IRI) with a simultaneous decrease in the level of CD8 + T-lymphocytes, The decrease of CD25+ activated Tand B-lymphocytes carrying the receptor for interleukin 2, and CD95+ activated Tand B-lymphocytes carrying the Fas-receptor, the decrease of complement activity, circulating immune complexes (CIC), IgM, IgA levels with an increase of IgG.Conclusion. Local PDT activates local immunity in patients with maxillofacial and neck phlegmons. Exposure to PDT causes a more balanced immune system response by increasing the innate immune response in patients and a pronounced immunological reactivity in the region of the postoperative wound.

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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence

Cited by 2 publications

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Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

State of local immune in phegmon of the maxillofacial region and neck on the background local photodynamic therapy

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