Immune status affects the clinical features and outcomes of adult patients with respiratory adenovirus infection

Zhao, Handan; Zhou, Ming; Zheng, Qiang; Lang, Guanjing; Xu, Lijun

doi:10.1017/s0950268821002272

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…HAdVs are major public health concerns and are linked to various clinical manifestations of multiple mucosal sites, including respiratory, gastroenteritis, ocular and urinary tract (Das and Basu 2020 ; Grand 2023 ; Nanmoku et al 2016 ). They are associated with chronic infections in both healthy and immunocompromised patients and can produce severe or deadly illnesses in children and the elderly (Spaeder et al 2022 ; Zhao et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of human adenoviruses associated with pediatric respiratory infections in Karachi, Pakistan

Mahmood,

Ahmed,

Farooq

et al. 2024

BMC Infect Dis

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Human adenoviruses (HAdVs) are a diverse group of viruses associated with respiratory infections in humans worldwide. However, there is a lack of research on the genetic diversity and epidemiology of HAdVs in Pakistan. This study characterized HAdVs in pediatric patients with respiratory tract infections in Karachi, Pakistan, between 2022 and 2023. We analyzed 762 nasopharyngeal samples of children ≤ 5 years. DNA extraction, followed by PCR targeting E2B and hexon genes, was carried out. Data analysis was performed on SPSS 25.0, and phylogenetic analysis of hexon gene was performed on MEGA 11. HAdV was detected in 7.34% (56/762) of patients round the year, but at a significantly higher rate during the winter season. Age was insignificantly associated with HAdV incidence (p = 0.662), but more than 62.5% (35/56) of positive cases were younger than 10 months. The circulating HAdVs were identified as six different types from species B (78.57%) and C (21.42%), with the majority of isolates found to be like B3. HAdV was found to be co-infected with bocavirus (5.4%) and measles (7.14%). These findings revealed a high frequency and genetic diversity of respiratory HAdVs in Karachi, Pakistan. We conclude that periodic and continuous surveillance of adenoviruses and other respiratory pathogens is necessary to improve the prognosis and management of respiratory diseases, thereby reducing the child mortality rate in Pakistan.

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