Immune signaling in sex-specific neural and behavioral development: Adolescent opportunity

King'uyu, David N; Stephens, Shannon B. Z.; Kopec, Ashley M.

doi:10.1016/j.conb.2022.102647

Cited by 4 publications

(2 citation statements)

References 66 publications

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“…We demonstrate that developmental stage and sex also play a role in the vulnerability to opioid exposure. This is an important link built on the knowledge that males and females adolescent development occurs at different periods, with females generally moving into puberty earlier than males (Butler & Purushothaman, 2020; Euling et al, 2008; King’uyu et al, 2022; Kopec et al, 2018; Mendle et al, 2019; Peper et al, 2020; Vijayakumar et al, 2018) including social development (Kopec et al, 2018; Pfeifer & Allen, 2021; Reddy et al, 2022). Therefore, we expected that morphine-induced sociability deficits would differ by period of exposure, and that female deficits would be restricted to morphine exposure during the female critical period and vice versa for males.…”

Section: Discussionmentioning

confidence: 99%

Section: Sex-specific Vulnerability Of Social Development To Morphine...mentioning

confidence: 99%

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Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.

King'uyu,

Edgar,

Figueroa

et al. 2024

Behavioral Neuroscience

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Drug exposure during adolescence, when the “reward” circuitry of the brain is developing, can permanently impact reward-related behavior into adulthood. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently in the United States is affecting younger individuals raising the impetus to understand the pathogenesis of the negative effects of opioids. One reward-related behavior that develops during adolescence is social behavior. We previously demonstrated that developmental changes in the nucleus accumbens reward region regulate social development in rats during sex-specific adolescent periods: early to mid-adolescence in males (postnatal day, P30–40) and preearly adolescence in females (P20–30). We thus hypothesized that the developmental stage of morphine exposure will differentially impact social behavior development such that drug administered during the female critical period would result in adult sociability deficits in females, but not males, and morphine administered during the male critical period would result in adult sociability deficits in males, but not females. We found that morphine exposure during the female critical period primarily resulted in deficits in sociability in females, while morphine exposure during the male critical period primarily resulted in deficits in sociability primarily in males. However, depending on the test performed and the social parameter measured, social alterations could be found in both sexes that received morphine exposure at either adolescent stage. These data indicate that when drug exposure occurs during adolescence, and how the endpoint data are measured, will play a large role in determining the effects of drug exposures on social development.

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Section: Discussionmentioning

confidence: 99%

Section: Sex-specific Vulnerability Of Social Development To Morphine...mentioning

confidence: 99%

Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.

King'uyu,

Edgar,

Figueroa

et al. 2024

Behavioral Neuroscience

View full text Add to dashboard Cite

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Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test

King'uyu¹,

Edgar²,

Figueroa³

et al. 2023

Preprint

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Drug exposure during adolescence, when the "reward" circuitry of the brain is developing, can permanently impact reward-related behavior. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently in the United States is affecting younger individuals raising the impetus to understand the pathogenesis of the negative effects of opioids. One reward-related behavior that develops during adolescence is social behavior. We previously demonstrated that social development occurs in rats during sex-specific adolescent periods: early to mid-adolescence in males (postnatal day (P)30-40) and pre-early adolescence in females (P20-30). We thus hypothesized that morphine exposure during the female critical period would result in adult sociability deficits in females, but not males, and morphine administered during the male critical period would result in adult sociability deficits in males, but not females. We found that morphine exposure during the female critical period primarily resulted in deficits in sociability in females, while morphine exposure during the male critical period primarily resulted in deficits in sociability primarily in males. However, depending on the test performed and the social parameter measured, social alterations could be found in both sexes that received morphine exposure at either adolescent stage. These data indicate that when drug exposure occurs during adolescence, and how the endpoint data are measured, will play a large role in determining the effects of drug exposures on social development.

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Social aging trajectories are sex-specific, sensitive to adolescent stress, and most robustly revealed during social tests with familiar stimuli

Figueroa¹,

Edgar²,

Kirkland³

et al. 2023

Preprint

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Social networks and support are integral to health and wellness across the lifespan, and social engagement may be particularly important during aging. However, social behavior and social cognition decline naturally during aging across species. Social behaviors are in part supported by the reward circuitry, a network of brain regions that develops during adolescence. We published that male and female rats undergo adolescent social development during sex-specific periods, pre-early adolescence in females and early-mid adolescence males. Although males and females have highly dimorphic development, expression, and valuation of social behaviors, there is relatively little data indicating whether social aging is the same or different between the sexes. Thus, we sought to test two hypotheses: (1) natural social aging will be sex-speciifc, and (2) social isolation stress restricted to sex-specific adolescent critical periods for social development would impact social aging in sex-specific ways. To do this, we bred male and female rats in-house, and divided them randomly to receive either social isolation for one week during each respective critical period, or no manipulation. We followed their social aging trajectory with a battery of five tests at 3, 7, and 11 months of age. We observed clear social aging signatures in all tests administered, but sex differences in natural social aging were most robustly observed when a familiar social stimulus was included in the test. We also observed that adolescent isolation did impact social behavior, in both age-independent and age-dependent ways, that were entirely sex-specific.

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Immune signaling in sex-specific neural and behavioral development: Adolescent opportunity

Cited by 4 publications

References 66 publications

Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.

Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.

Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test

Social aging trajectories are sex-specific, sensitive to adolescent stress, and most robustly revealed during social tests with familiar stimuli

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