Immune sexual dimorphism: Effect of gonadal steroids on the expression of cytokines, sex steroid receptors, and lymphocyte proliferation

León-Nava, Marco A. De; Nava, Karen; Soldevila, Gloria; López-Griego, Lorena; Chávez‐Ríos, Jesús R.; Vargas-Villavicencio, José Antonio; Morales‐Montor, Jorge

doi:10.1016/j.jsbmb.2008.11.003

Cited by 71 publications

(46 citation statements)

References 27 publications

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“…The immunomodulatory effect of the hormone has been demonstrated by decreased secretion of pro-inflammatory cytokines IL-2 and IL-17, and increased production of anti-inflammatory IL-10, in addition to increased numbers of CD19+ cells and CD8+ cells. Inhibited Th1-and enhanced Th2-type immune responses by progesterone have been previously reported by Piccinni et al [12], Drew and Chavis [85], Miyaura et al [86], Hughes et al [87], and De Leon-Nava et al [88]. Neuroprotective properties of the hormone have also been evidenced in different experiments [89,90].…”

Section: Influence Of Gender and Sex Hormones On Eaementioning

confidence: 58%

Sex Hormones and Multiple Sclerosis

Trenova¹

2016

Trending Topics in Multiple Sclerosis

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Experimental and clinical data about the influence of sex hormones on the course of multiple sclerosis (MS) grow rapidly during the past two decades. Estrogens, progesterone, and androgens have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in animals, and pregnancy in women is associated with a dramatic reduction in disease activity. Immunomodulatory and neuroprotective properties of sex hormones are the most probable underlying mechanisms, creating a background for testing similar hormonal treatments in humans. Several pilot studies in this field present promising results, but larger trials are necessary to identify the adverse events and to estimate precisely the place of sex steroids in multiple sclerosis therapeutic strategies.The objective of this chapter is to summarize the recent advances in the research about the effects of sex steroids in EAE and MS and to create a ground for the development of more powerful treatments in the future.

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Section: Influence Of Gender and Sex Hormones On Eaementioning

confidence: 58%

Sex Hormones and Multiple Sclerosis

Trenova¹

2016

Trending Topics in Multiple Sclerosis

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“…These data were also supported by in vitro experiments proving significant effects of female gonadal hormones (but not testosterone) on the gene expression levels of these cytokines in splenocytes. On the other hand, the same study found no evidence for an effect of sex on gene expression levels of IL-2 or IL-6 (De León-Nava et al, 2009). Other in vitro studies revealed stimulation of the gene expression of IL-2, IL-3 and IL-5 by both female and male gonadal steroids in human T-cell lines (Wang et al, 1993).…”

Section: Discussionmentioning

confidence: 88%

“…Studies in mammals indicate that gonadal steroids may modulate the activity of the immune system, among other effects by influencing the proliferation and activity of lymphocytes (Landsman et al, 2001;De León-Nava et al, 2009). Since macrophages possess receptors for gonadal steroids (Wunderlich et al, 2002;Khan et al, 2005;Murphy et al, 2009), another possible mechanism might be the alteration of cytokine and chemokine production.…”

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confidence: 99%

Preliminary results on intersexual differences in gene expression of chemokine K203 in mononuclear cells of chicken

Kankova

Zeman

Schwarz

et al. 2016

Acta Veterinaria Hungarica

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Sex steroid levels increase during sexual maturation and cause alterations in many physiological and morphological traits. Some of these changes may be connected with age-dependent and intersexual differences in the immune system. This topic is still insufficiently understood, especially in avian species, partially due to methodological limitations. In this study we measured the gene expression of proinflammatory cytokines (IL-1β, IL-6, IL-18) and chemokines [K60 (IL-8-like chicken chemokine -CXCLi1), CAF (IL-8-like chicken chemokine -CXCLi2), and K203] in mononuclear cells isolated from blood and spleen after in vitro stimulation with lipopolysaccharide (LPS). Samples were collected from chickens at two ages (from pullets before sexual maturity and from sexually mature egglaying hens). After LPS stimulation, a substantial increase was recorded in the gene expression of IL-6 and K203. All other measured genes were expressed at low levels in mononuclear cells irrespective of cell sources. We found a trend toward intersexual differences in K203 expression, but the expression of other cytokines and chemokines did not differ between the two sexes. The effect of stimulation was more pronounced in monocytes than in spleen macrophages, mainly in IL-6, IL-1β and K203 gene expression. Our findings represent a basis for further studies on the effects exerted by sexual hormones on the immune phenotype of birds.

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“…Так же, как и гипоталамо-гипофизарно-надпочечниковая и гипоталамо-гипофизар-но-тиреоидная оси, гипоталамо-гипофизар-но-гонадная система модулирует иммунные функции [23]. Наиболее значимыми для ре-гуляции иммунной системы считаются эст-рогены.…”

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“…Наиболее значимыми для ре-гуляции иммунной системы считаются эст-рогены. В общем физиологические концен-трации эстрогенов усиливают иммунный ответ, тогда как физиологические концен-трации андрогенов, таких как тестостерон и дегидроэпиандростерон, оказывают имму-носупрессивный эффект [22,23]. Женский пол является фактором, увеличивающим риск развития многих системных аутоим-мунных заболеваний, таких как системная красная волчанка, ревматоидный артрит и рассеянный склероз.…”

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The analysis of the co-regulation between the immune and neuroendocrine systems under exposure to risk factors

Lanin¹

2013

Health Risk Analysis

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Анализ корегуляции иммунной и нейроэндокринной систем в условиях воздействия факторов риска 73 АНАЛИТИЧЕСКИЕ ОБЗОРЫ УДК 613.954: 612.4.09 АНАЛИЗ КОРЕГУЛЯЦИИ ИММУННОЙ И НЕЙРОЭНДОКРИННОЙ СИСТЕМ В УСЛОВИЯХ ВОЗДЕЙСТВИЯ ФАКТОРОВ РИСКА Д.В. ЛанинФедеральный научный центр медико-профилактических технологий управления рисками здоровью населения, Россия, 614045, г. Пермь, ул. Монастырская, 82Проанализированы данные литературы о корегуляции иммунной и нейроэндокринной систем и ее изменении в условиях воздействия химических факторов. Обозначены подходы к выявлению маркеров эффекта для оценки риска развития дисфункции регуляторных систем в условиях воздействия различных факторов риска.Ключевые слова: химические факторы, иммунная система, нейроэндокринная система.

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Immune sexual dimorphism: Effect of gonadal steroids on the expression of cytokines, sex steroid receptors, and lymphocyte proliferation

Cited by 71 publications

References 27 publications

Sex Hormones and Multiple Sclerosis

Sex Hormones and Multiple Sclerosis

Preliminary results on intersexual differences in gene expression of chemokine K203 in mononuclear cells of chicken

The analysis of the co-regulation between the immune and neuroendocrine systems under exposure to risk factors

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