Immune Sensitization in the Skin Is Enhanced by Antigen-Independent Effects of IgE

Bryce, Paul J.; Miller, Mendy; Miyajima, Ichiro; Tsai, Mindy; Galli, Stephen J.; Oettgen, Hans C.

doi:10.1016/s1074-7613(04)00080-9

Cited by 171 publications

(191 citation statements)

References 52 publications

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“…However, identifying and characterizing specific immunomodulatory roles of mast cells during particular immune responses in vivo may be quite challenging. For example, it already is clear that mast cells can have either positive or negative immunomodulatory functions in what would appear to be very similar settings, such as in different mouse models of CHS that employ different types and/or concentrations of haptens and/or different vehicles for administering these haptens 5,13,60,87,88 (Figure 3). One may even speculate that in immune responses in which mast cells first promote the sensitization phase of the response, mast cells could then help to initiate the local inflammation that occurs when the host is subsequently exposed to specific antigen, and finally help to limit the extent of, and/or resolve, the ensuing inflammation and associated tissue pathology.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

2008

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Section: Discussionmentioning

confidence: 99%

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

2008

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“…For example, Bryce et al (48) have shown that mast cells are required for contact sensitivity and dendritic cell reduction in the epidermis following hapten exposure. However, our results indicate that LC migration to draining LNs can be induced by IgE-mediated mast cell activation.…”

Section: Discussionmentioning

confidence: 99%

IgE-Mediated Mast Cell Activation Induces Langerhans Cell Migration In Vivo

Jawdat

Albert

Rowden

et al. 2004

The Journal of Immunology

123

118

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Langerhans cells and mast cells are both resident in large numbers in the skin and act as sentinel cells in host defense. The ability of mast cells to induce Langerhans cell migration from the skin to the draining lymph node in vivo was examined. Genetically mast cell-deficient (W/Wv) mice and control mice were sensitized with IgE Ab in the ear pinna. Seven to 14 days later, mice were challenged with Ag i.v. After a further 18–24 h, epidermal sheets and draining auricular lymph nodes were examined using Langerin/CD207 immunostaining. In mast cell-containing mice, a significant decrease in the number of Langerhans cells was observed at epidermal sites of mast cell activation. A significant increase in total cellularity and accumulation of Langerin-positive dendritic cells was observed in the auricular lymph nodes, draining the sites of IgE-mediated mast cell activation. These changes were not observed in W/Wv mice, but were restored by local mast cell reconstitution. Treatment of mast cell-containing mice with the H2 receptor antagonist cimetidine significantly inhibited the observed IgE/Ag-induced changes in Langerhans cell location. In contrast, Langerhans cell migration in response to LPS challenge was not mast cell dependent. These data directly demonstrate the ability of mast cells to induce dendritic cell migration to lymph nodes following IgE-mediated activation in vivo by a histamine-dependent mechanism.

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“…Moreover, studies using genetically mast cell-deficient mice have shown that mast cells can promote the migration of Langerhans cells from the epidermis upon hapten sensitization in a model of oxazolone-induced contact hypersensitivity (6) and that the IgEand Ag-dependent activation of skin mast cells can promote the migration of skin DCs to local draining lymph nodes by a mechanism that is in part H 2 histamine receptor-dependent (7).…”

Section: Ast Cells Represent Important Effector Cells In Th2-andmentioning

confidence: 99%

“…We tested three populations of BMCMCs by FACS analysis: nonsensitized (naive), IgE-sensitized, and IgE-and Ag-stimulated (IgE/Ag), because we and other investigators have reported evidence that occupancy (and perhaps cross-linking) of the high affinity IgE receptor, Fc⑀RI, by IgE alone can enhance mast cell survival and/or function (6,32,33). We found that naive BMCMCs from C57BL/6J, WB ϫ B6 F 1 hybrid, or BALB/cKa mice did not express detectable levels of MHC class II (I-A) molecules on their cell surface (No IgE cells in Fig.…”

Section: Expression Of Members Of the B7 And Cd28 Families Of Costimumentioning

confidence: 99%

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

Nakae

Suto

Iikura

et al. 2006

The Journal of Immunology

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354

316

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We recently reported that mast cells stimulated via FcεRI aggregation can enhance T cell activation by a TNF-dependent mechanism. However, the molecular mechanisms responsible for such IgE-, Ag- (Ag-), and mast cell-dependent enhancement of T cell activation remain unknown. In this study we showed that mouse bone marrow-derived cultured mast cells express various costimulatory molecules, including members of the B7 family (ICOS ligand (ICOSL), PD-L1, and PD-L2) and the TNF/TNFR families (OX40 ligand (OX40L), CD153, Fas, 4-1BB, and glucocorticoid-induced TNFR). ICOSL, PD-L1, PD-L2, and OX40L also are expressed on APCs such as dendritic cells and can modulate T cell function. We found that IgE- and Ag-dependent mast cell enhancement of T cell activation required secreted TNF; that TNF can increase the surface expression of OX40, ICOS, PD-1, and other costimulatory molecules on CD3+ T cells; and that a neutralizing Ab to OX40L, but not neutralizing Abs to ICOSL or PD-L1, significantly reduced IgE/Ag-dependent mast cell-mediated enhancement of T cell activation. These results indicate that the secretion of soluble TNF and direct cell-cell interactions between mast cell OX40L and T cell OX40 contribute to the ability of IgE- and Ag-stimulated mouse mast cells to enhance T cell activation.

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Immune Sensitization in the Skin Is Enhanced by Antigen-Independent Effects of IgE

Cited by 171 publications

References 52 publications

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

IgE-Mediated Mast Cell Activation Induces Langerhans Cell Migration In Vivo

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

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