Immune Senescence and Inflammaging in Neurological Diseases

Baden, Pascale; Cicco, Silvia De; Yu, Cong; Deleidi, Michela

doi:10.1007/978-3-319-99375-1_143

Cited by 1 publication

(1 citation statement)

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“…However, HCMV chronic infection has been shown to drive the expansion of immune cells that are associated with numerous inflammatory pathologies such as cardiovascular disease, COVID-19, and SMI [ 16 , 34 , 35 , 36 , 37 ]. In addition, chronic HCMV infection, inflammaging, and advancing age significantly affect the immune system, ultimately contributing to the onset of various diseases [ 11 , 16 , 38 , 39 ]. Besides, a recent study has recently shown that the response to HCMV depends on the sex of the individual [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Spanish HCMV Seroprevalence in the 21st Century

Álvarez-Heredia,

Reina-Alfonso,

Domínguez-del-Castillo

et al. 2023

Viruses

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Human cytomegalovirus (HCMV) is linked to age-related diseases like cardiovascular disease, neurodegenerative conditions, and cancer. It can also cause congenital defects and severe illness in immunocompromised individuals. Accurate HCMV seroprevalence assessment is essential for public health planning and identifying at-risk individuals. This is the first HCMV seroprevalence study conducted in the general Spanish adult population in 30 years. We studied HCMV seroprevalence and HCMV IgG antibody titres in healthy adult donors (HDs) and HCMV-related disease patients from 2010 to 2013 and 2020 to 2023, categorized by sex and age. We compared our data with 1993 and 1999 studies in Spain. The current HCMV seroprevalence among HDs in Spain is 73.48%. In women of childbearing age, HCMV seroprevalence has increased 1.4-fold in the last decade. HCMV-seropositive individuals comprise 89.83% of CVD patients, 69% of SMI patients, and 70.37% of COVID-19 patients. No differences in HCMV seroprevalence or HCMV IgG antibody titres were observed between patients and HDs. A significant reduction in Spanish HCMV seroprevalence among HDs was observed in 1993. However, women of childbearing age have shown an upturn in the last decade that may denote a health risk in newborns and a change in HCMV seroprevalence trends.

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