Immune responsiveness of monkeys exposed chronically to cigarette smoke

Sopori, Mohan L.; Gairola, Chandra C.; DeLucia, Anthony J.; Bryant, Lester R.; Cherian, Susamma

doi:10.1016/0090-1229(85)90054-6

Cited by 32 publications

(14 citation statements)

References 19 publications

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“…T-cell activation, proliferation and expression of the cytotoxic proteins are significantly reduced by exposure to cigarette smoke [68]. Spleen cells from animals that are subjected to the heavy dose of cigarette smoke have a significant reduction in their natural killer cell-mediated lytic activity and a decreased response to concanavalin A [73]. Cigarette smoke impairs NK cell-dependent tumor immune surveillance which further suggests that the immune response to antigens is altered in these cells [74].…”

Section: Effects Of Cigarette Smoking On Alveolar Lymphocytes and Nk mentioning

confidence: 92%

Cigarette smoking and innate immunity

2008

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Cigarette smoking is a worldwide epidemic and the most prevalent cause of many diseases leading to increased morbidity and mortality globally. The impact of smoking on pathogenesis of cancer is being extensively studied however cigarette smoke as an immunosuppressant is less well recognized. Here we review the immunosuppressive effects of cigarette smoke and the mechanisms by which smoking affects host innate immunity including structural and functional changes in the respiratory ciliary epithelium, lung surfactant protein, and immune cells such as alveolar macrophages, neutrophils, lymphocytes and natural killer (NK) cells. Thus smoking cessation should be emphasized not only for prevention of cancer and coronary artery disease but also for patients with recurrent infections and immunosuppressive states.

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Section: Effects Of Cigarette Smoking On Alveolar Lymphocytes and Nk mentioning

confidence: 92%

Cigarette smoking and innate immunity

2008

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“…Pulmonary macrophages from smokers are less ef ficient as accessory cells in lymphoproliferative re sponses to antigens compared to those from nonsmokers [Laughter et al, 1977], Furthermore, smokers show an increase of pulmonary macrophages and a changed immune responsiveness of the lung cells, and circulatory lymphocyte levels are increased, including both surface immunoglobulin bearing cells and T cells [Hughes et al, 1985], Functional studies suggest that different subsets of lymphocytes are differently affected by smoking [Sopori et al, 1985]. Thus, the significantly lower levels of antibacterial antibody in smokers as concerns preferentially the IgG class may also be a consequence of effect of smoking on the an tigen processing by macrophages and the regulation of antibody synthesis.…”

Section: Discussionmentioning

confidence: 99%

Serum Antibodies to <i>Pseudomonas pseudoalcaligenes</i> in Metal Workers Exposed to Infected Metal-Working Fluids

Mattsby‐Baltzer

Edebo²,

Järvholm³

et al. 1989

Int Arch Allergy Immunol

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Metal workers exposed to aerosol from metal-working fluid were examined with respect to serum antibody to the lipopolysaccharide (LPS) of Pseudomonas pseudoalcaligenes. During 1 year of observation this species grew at high concentrations in the fluid (∼ 10⁸ CFU/ml), and the air surrounding the metal-working machines sometimes contained more than 10⁵ CFU/m³. The levels of antibody belonging to the IgG and IgA classes were significantly higher than in blood donors and in workers newly employed. Comparison with employees not working in the machine hall showed a significantly higher IgG, but not IgA, antibody level. For IgM antibody no such difference was found. Among the exposed workers, non-smokers had significantly higher IgG antibody levels than smokers, whereas no such difference was established for IgA and IgM antibodies. In smokers the IgG antibody level seemed to decline in the long-range time, since there was a negative correlation between the time of employment with exposure to metal-working fluids and IgG antibody level. The antibody data indirectly demonstrate that P. pseudoalcaligenes grown in metal-working fluid penetrated the body surface of metal workers to yield an immune response most probably after inhalation of aerosol containing bacteria. In the metal workers this long-term exposure did not lead to any acute or chronic respiratory discomfort.

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“…Silverman et al 3) found the lymphocyte reactivity to PHA to be significantly higher in smokers under 40 years of age. In contrast to the diversity of lymphocyte reactivity in smokers, natural killer cell activity has been reported to be consistently depressed5, 10,11,16). A follow-up study in normal subjects following the cessation of smoking indicated that the increased count of lymphocytes and depressed natural killer cell activity were reversed9).…”

Section: Resultsmentioning

confidence: 99%