Immune responsiveness in orthopedic surgery patients after transfusion of autologous or allogeneic blood

Abstract

The transfusion of buffy coat-depleted red cells showed no immediate suppressive effect on the immune function of the host's peripheral blood cells.

Distinct Effects of Allogeneic Blood Transfusion on Splenocyte Cytokine Production after Hemorrhagic Shock

“…These IL-2 reductions were seen at various time neic blood showed no alteration in NK cell counts or cytokine production compared to patients receiving points following transfusion and were of a prolonged duration (up to 14 days post-transfusion). This is in similarly prepared autologous blood [29]. This adds further indirect evidence that the leukocyte component of sharp contrast to our results which showed a marked increase in IL-2 production on postshock Day 2 seen transfused blood is largely responsible for the alterations in NK activity and cytokine profiles typically in mice which had received allogeneic blood, as compared to autologous blood recipients.…”

The effect of unmodified or prestorage white cell‐reduced allogeneic red cell transfusions on the immune responsiveness in orthopedic surgery patients

“…For the induction of interleukin (IL)‐2, IL‐6, IL‐10, tumor necrosis factor α (TNFα), and interferon γ (IFNγ), venous blood was drawn on Days 0, 1, and 4 into a heparin‐anticoagulated glass tube (Vacutainer, Becton Dickinson Immuno Systems) and cultured in a modified whole blood technique as described previously 14,15 . Within 2 hours after blood collection, we added purified diluted phytohemagglutinin (PHA) as mitogen solution for the induction of cytokines.…”

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

“…The preliminary results were encouraging showing predeposit autologous blood to reduce transfusion-associated immunosuppression and postoperative infectious complications compared to allogeneic blood transfusion [49,50]. However, recent results have indicated that blood transfusion-induced immunosuppression by predeposit autologous blood is similar to allogeneic blood [51][52][53], which support the findings of similar detrimental prognosis in cancer patients transfused with predeposit autologous blood or allogeneic blood [54,55]. In addition, the well-known posttransfusion febrile reactions are observed after transfusion with predonated autologous blood as well [56].…”