Immune responses to oligomeric α-synuclein in Parkinson’s disease peripheral blood mononuclear cells
Ana Florencia Vega-Benedetti,
Clara Porcedda,
Tommaso Ercoli
et al.
Abstract:Parkinson’s disease displays clinical heterogeneity, presenting with motor and non-motor symptoms. Heterogeneous phenotypes, named brain-first and body-first, may reflect distinct α-synuclein pathology starting either in the central nervous system or in the periphery. The immune system plays a prominent role in the central and peripheral pathology, with misfolded α-synuclein being placed at the intersection between neurodegeneration and inflammation. Here, we characterized the inflammatory profile and immune-p… Show more
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