Immune Responses to Mumps Vaccine in Adults Who Were Vaccinated in Childhood

Hanna-Wakim, Rima; Yasukawa, Linda L.; Sung, Phillip; Arvin, Ann M.; Gans, Hayley A.

doi:10.1086/588195

Cited by 57 publications

(46 citation statements)

References 36 publications

(40 reference statements)

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“…Similar findings were reported by Jokinen et al, who found mumps antigen-speciˆc lymphoproliferative response in 100z of subjects that naturally acquired immunity to the mumps virus (16). In research performed by Hanna-Wakim et al, 80z of naturally immune individuals had a positive stimulation index (15). Cell-mediated immunity to mumps in vaccinated individuals was lower than that in naturally immune adults (15,16).…”

Section: Discussionsupporting

confidence: 82%

“…In research performed by Hanna-Wakim et al, 80z of naturally immune individuals had a positive stimulation index (15). Cell-mediated immunity to mumps in vaccinated individuals was lower than that in naturally immune adults (15,16). There was a significant correlation between frequency of CTLs and proliferation of CD8＋ T lymphocytes.…”

Section: Discussionmentioning

confidence: 89%

“…Mumps is still one of the great problem of health in developing countries, despite the availability of safe and effective vaccines (10)(11)(12)(13)(14), and the wild-type mumps virus continues to cause outbreaks throughout the world (15). In 2006, a mumps outbreak occurred in the United States, although the majority of the patients aged 18-24 years being vaccinated with 2 doses of mumps vaccine.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas published reports concerning the efficacy of the mumps vaccine describe efficacy over 90z (15), levels of antibodies to mumps decline rapidly within years of vaccination, after an initial peak (16). It has been reported that natural mumps infection, in contrast, confers lifetime protection (17).…”

Section: Introductionmentioning

confidence: 99%

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Immune Response to the Mumps Virus in Iranian Unvaccinated Young Adults

et al. 2017

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SUMMARY: Although the first mumps vaccine was licensed more than 50 years ago, the vaccine was added to Iran's Expanded Program on Immunization in 2003. Therefore, the majority of Iranians born before 2003 are unvaccinated, and their immunity is the result of natural infection. In order to evaluate cellular responses against the mumps virus following natural infection, we investigated 90 Iranian unvaccinated adults aged 20-30 years. Mumps specific memory CD4＋ and CD8＋ proliferation and frequency of cytotoxic lymphocyte CD8＋ CD107a were evaluated using flow cytometry. Our results showed that 33 subjects were seronegative, but 28 of them showed degranulation of CD8＋ T lymphocytes and expression of CD 107a, as well as proliferation of CD4 and CD8 T cells, in response to mumps antigen stimulation. In all seropositive subjects, degranulation of cytotoxic T lymphocytes and proliferation of CD4＋ and CD8＋ T lymphocytes was detected. Proliferation of T cells and degranulation of CD8 T cells in seropositive subjects was higher than in seronegative subjects. We conclude that natural mumps infection and subclinical reinfection could induce good protection, but the severe complications associated with mumps infections suggest the need for mumps vaccination. Natural boosters because of the prevalence of the wild-type virus may help with maintenance of immunity in populations with high vaccine coverage.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immune Response to the Mumps Virus in Iranian Unvaccinated Young Adults

et al. 2017

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“…This suggested that certain population groups might be incompletely vaccinated, and that the humoral immunity provided by vaccination gradually declined over time. The seropositivity rate increased again after 20 years of age, probably as a consequence of natural infection from greater exposure to the surrounding community [13].…”

Section: Discussionmentioning

confidence: 97%

Mumps antibody in the Thai population 17 years after the universal measles mumps rubella vaccination program

Ngaovithunvong

Wanlapakorn

Tesapirat

et al. 2016

J Infect Dev Ctries

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Introduction: mumps vaccination implementation in the form of MMR -measles, mumps, and rubella) in Thailand for first-grade school students since 1997 and for infants 9-12 months of age since 2010 resulted in a dramatic decline in the incidence of and deaths from mumps. However, there has been a resurgence of mumps outbreaks in Thailand, even in vaccinated populations. Methodology: We aimed to determine the current seroprevalence of IgG antibodies to mumps in those 0-60 years of age from four different geographic areas of Thailand, and compare the results with our previous serosurvey in 2004. Results: Seropositivity rates in children 0-7 years of age increased significantly from 45.8% in 2004 to 72.3% in 2014 after the launch of the MMR vaccine for infants. In the 8-14-year age group who had received one dose of mumps vaccination, the seropositivity rate was 66.7%. In the 15-19-year age group the seropositivity rate was the lowest, at 52.5%. Discussion: Our findings correspond well with the vaccination schedules, as the highest seropositivity rate was found in children between 0 and 7 years of age. For those older than 7, there was a decline in seropositivity rate despite good vaccine coverage and reached its lowest in the 15-19-year age group. This suggested that certain population groups might be incompletely vaccinated, or the humoral immunity provided by vaccination gradually declined over time. Conclusions: We recommend a booster dose of MMR vaccine for Thai adolescents in order to prevent future mumps outbreaks.

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Paramyxoviruses: Mumps

Rubin

2014

Viral Infections of Humans

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Immune Responses to Mumps Vaccine in Adults Who Were Vaccinated in Childhood

Abstract: T and B cell immunity to mumps was detected in adults at least 10 years after immunization. Except for IFN-gamma release, responses in vaccinated adults paralleled those observed in naturally immune individuals.

Cited by 57 publications

References 36 publications

Immune Response to the Mumps Virus in Iranian Unvaccinated Young Adults

Immune Response to the Mumps Virus in Iranian Unvaccinated Young Adults

Mumps antibody in the Thai population 17 years after the universal measles mumps rubella vaccination program

Paramyxoviruses: Mumps

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