Immune responses, DNA damage and ultrastructural alterations of gills in the marine mussel Lithophaga lithophaga exposed to CuO nanoparticles

Essawy, Amina E.; Sherif, Soheir S El; Osman, Gamalat Y.; Morshedy, Rehab M El; Al-Nasser, Abir S.; Sheir, Sherin K.

doi:10.1007/s11356-021-16889-6

Cited by 7 publications

(2 citation statements)

References 57 publications

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“…The herein data showed that the phagocytic activity of B. alexandrina recorded a significant decrease after 24 hours of exposure to CAAQ and/or S. mansoni infection. The lysosomes of haemocytes can accumulate large amounts of pollutants resulting in membrane instability, which leads to cell damage and incompatibility (Nicholson, 2001;Essawy et al, 2022). The later authors suggested that CuO NPs exposure inhibited the immune responses of mussels' haemocytes most likely via three pathways: (1) changes of the in vivo content of neurotransmitters; (2) induction of reactive oxygen species, which reduces the cell viability of haemocytes and causes DNA damage; and (3) affecting the expression of immune-and neurotransmitter-related genes.…”

Section: Discussionmentioning

confidence: 99%

The efficiency of N-heterocylic analogs against Biomphalaria alexandrina snails infected with Schistosoma mansoni; immune responses, histological structure and protein pattern

Mohamad et al.

2023

Egypt. J. of Aquatic Biolo. and Fish.

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Section: Discussionmentioning

confidence: 99%

The efficiency of N-heterocylic analogs against Biomphalaria alexandrina snails infected with Schistosoma mansoni; immune responses, histological structure and protein pattern

Mohamad et al.

2023

Egypt. J. of Aquatic Biolo. and Fish.

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“…It is possible that TBT disturbance of the mitochondrial proton gradient could divert electrons from the respiratory chain, leading to the formation of reactive oxygen species (Puccia et al, 2001). In gill cells of M. edulis (Wilson et al, 1998), Lithophaga lithophaga (Essawy et al, 2021), Donax incarnatus (Dias et al, 2021), and M. coruscus (Xu et al, 2018), oxidative DNA damage generated by reactive oxygen species has been attributed to the high and variable DNA damage.…”

Section: Dna Damagementioning

confidence: 99%

DNA damage and shell malformation in Blue Mussel, <i>Mytilus edulis</i>

Yaqin

2022

Akuatikisle: J. Aqua. Coast. & Isle

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Pollutants in waters that cause DNA damage, such as tributyltin, have been known to cause malformations in the mussel shell, which need attention to be studied. Shell malformations or deformities of blue mussels were observed in Norsminde Fjord harbour. The mean shell thickness index of blue mussels from the polluted site was greater than it from expected clean waters. DNA damages detected using the versatile comet assay which expressed as tail length and olive tail moment were evaluated in blue mussels gill cells both in situ and in vitro. The results showed that the average of DNA damages in treatments, namely the polluted site, tributyltin chloride (TBTC) (10 g/l), and hydrogen peroxide (H2O2) (10 M) were different from the expected unpolluted site. Although comet assay is considered as an unspecific assay, the results proposed the similarity of DNA damage character of blue mussel gill cells when exposed to tributyltin chloride and taken directly from the polluted site. The data obtained are important for assessing the environmental risks created by genotoxic agents, e.g. tributyltin, used as antifouling agents in marine paints.

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The potential ameliorative role of Dimercaptosuccinic acid against the toxicity of Titanium Dioxide Nanoparticles on Caelatura nilotica clams

Abdel‑Azeem,

Mohamed,

Osman

et al. 2024

J Exp Zool Pt A

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The prevalent use of nanoparticles has adverse negative effects on biosystems. Subsequently, this study aimed to use Caelatura nilotica to assess the ecotoxicity of TiO2 NPs and how Dimercaptosuccinic acid (DMSA) improves these effects. Two concentrations of TiO2 NPs (25 and 150 µg/L) were used for 28 days. TiO2 NPs bioaccumulation, gonadal weight, gonado‐somatic index, and histopathological alterations of gonads were determined. The tissues’ accumulation of TiO2 NPs was concentration‐time‐dependent: it was 78.5 ± 28.93 μg/g dry weight in the exposed clams to 150 µg/L TiO2 NPs after 4 weeks of exposure. The gonadal weight and gonado‐somatic index significantly decreased of the exposed group to 150 µg/L TiO2 NPs over the experimental period that they ended with values (1.01 ± 0.57 gm, 19.15 ± 7.75%, respectively). There are some histological alterations in the gonads of C. nilotica such as necrosis, deteriorated connective tissue, increased fibrous tissue, a reduced presence of mature sperms and mature ova, and irregular shapes of testicular/ovarian follicles. When using Dimercaptosuccinic acid (DMSA), this led to a reduction in accumulation of TiO2 NPs by the end of the experiment. So, C. nilotica is a promising model to reflect the adverse nano‐toxics. DMSA emerges as a potentially valuable chelating agent that abolishes the negative effects of these nanoparticles.

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Immune responses, DNA damage and ultrastructural alterations of gills in the marine mussel Lithophaga lithophaga exposed to CuO nanoparticles

Cited by 7 publications

References 57 publications

The efficiency of N-heterocylic analogs against Biomphalaria alexandrina snails infected with Schistosoma mansoni; immune responses, histological structure and protein pattern

The efficiency of N-heterocylic analogs against Biomphalaria alexandrina snails infected with Schistosoma mansoni; immune responses, histological structure and protein pattern

DNA damage and shell malformation in Blue Mussel, <i>Mytilus edulis</i>

The potential ameliorative role of Dimercaptosuccinic acid against the toxicity of Titanium Dioxide Nanoparticles on Caelatura nilotica clams

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