Immune Responses and Prediction of Major Infection in Patients Undergoing Transhiatal or Transthoracic Esophagectomy for Cancer

Sandick, Johanna W. van; Gisbertz, Suzanne S.; Berge, Ineke J. M. ten; Boermeester, Marja A.; Kraan, Tineke C. T. M. van der Pouw; Out, Theo A.; Obertop, H.; Lanschot, J. Jan B. van

doi:10.1097/00000658-200301000-00006

Cited by 69 publications

(44 citation statements)

References 33 publications

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“…Peritonitis patients may develop immunosuppression as a result of initially upregulated responses during intra-abdominal infection combined with the effects of surgery. Surgery itself can suppress the immune response (42), as was confirmed in experimental studies reported previously (1,37). Conditional immunosuppression plus low functional MBL levels may reduce the inhibition of yeast proliferation.…”

Section: Discussionsupporting

confidence: 61%

Mannose-Binding Lectin Deficiency Facilitates AbdominalCandidaInfections in Patients with Secondary Peritonitis

Till

Modderman

Boer

et al. 2008

Clin Vaccine Immunol

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Section: Discussionsupporting

confidence: 61%

Mannose-Binding Lectin Deficiency Facilitates AbdominalCandidaInfections in Patients with Secondary Peritonitis

Till

Modderman

Boer

et al. 2008

Clin Vaccine Immunol

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“…Previous studies demonstrated that T helper cells decreased and T suppressor cells increased significantly as early as 1 day after surgery [22][23][24] . Many subsequent studies also confirmed that surgery for patients with lung cancer [25] , esophageal cancer [26] , gastric cancer [27,28] and colorectal cancer [29,30] induced immediate severe immunosuppression. For cancer patients, an important function adversely affected by this immunosuppression is the anti-tumor response itself.…”

Section: Discussionmentioning

confidence: 85%

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Cai¹,

Bai²,

Yuan³

et al. 2004

WJG

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AIM:To study the effects of perioperative administration of cimetidine (CIM) on peripheral blood lymphocytes, natural killer (NK) cells and tumor infiltrating lymphocytes (TIL) in patients with gastrointestinal (GI) cancer. METHODS:Forty-nine GI cancer patients were randomized into treatment group, who took CIM in perioperative period, and control group, who did not take the drug. The treatment was initiated 7 days before operation and continued for 10 days after surgery. At baseline examination before operation, on the 2nd and 10th postoperative days, total T lymphocytes, T helper cells, T suppressor cells, and NK cells in peripheral blood were measured respectively by immunocytochemical method using mouse-anti human CD 3 , CD 4 , CD 8 and CD 57 monoclonal antibodies. Blood samples from 20 healthy volunteers were treated in the same way as normal controls. Surgical specimens were examined during routine histopathological evaluation for the presence of TIL in tumor margin. Immunohistochemical study was performed to measure the proportion of T and B lymphocytes in TIL population. T and B lymphocytes were detected respectively using mouse-anti-human CD 3 and CD 20 monoclonal antibodies. RESULTS:In comparison with normal controls, both the treatment and control groups had decreased T cells, T helper cells and NK cells at baseline. In control group, total T cells, T helper cells and NK cells declined continuously with the disease progression and the decrease became more obvious after operation. From baseline to the 2nd postoperative day, the proportion of total T cells, T helper cells, and NK cells went down from 60.5±4.6% to 56.2±3.8%, 33.4±3.7% to 28.1±3.4%, and 15.0±2.8% to 14.2±2.2%, respectively. On the other hand, there were significant improvements in these parameters after CIM treatment. On the 10th postoperative day, the treatment group had significantly higher percentages of total T cells, T helper cells and NK cells than control group. Moreover, CIM treatment also boosted TIL response, as was reflected by findings that 68% (17/25) of the patients in treatment group had significant TIL responses and only 25% (6/24) of the cases had discernible TIL responses (P<0.01). CONCLUSION:Perioperative application of CIM to GI cancer patients could help restore the diminished cellular immunity induced by tumor burden and surgical maneuver. The drug could also boost TIL responses to tumor. These effects suggest that the drug be used as an immunomodulator for GI cancer patients.

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“…Trans-Hiatal and Transthoracic techniques cause severe interruptions of monocytes and reduction of cytokine production by Tlymphocyte. Surgical procedures in esophageal cancer patients reduce the level of safety in the immune system (45).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Early and Late Complications in Three Esophagectomy Techniques

Mousavi¹,

Akbari²

2017

Int J Cancer Manag

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Background: Due to the high prevalence and mortality rates of esophageal cancer in some parts of the world and considering that in most patients, symptoms occur when cancer is advanced, this study aimed to compare early and late complications in three esophagectomy techniques for treatment of esophageal cancer. Methods: The present study was a descriptive research on 316 patients with esophageal cancer referring to Shohada Tajrish hospital, Tehran. The results were recorded in the research forms consisting of individual characteristics, symptoms and reasons for referring to the hospital. Findings were extracted after classification and evaluated using descriptive statistics. Results: Among 316 patients studied, 190 patients (60%) were male and 126 (40%) were female. The highest prevalence was between 40 and 60 years old. The most significant reason for referring to the hospital was dysphagia and weight loss. Among 260 patients, 72 patients (27.7%) underwent surgery by transthoracic (Ivor Lewis type) approach, 76 patients (29.2%) underwent surgery by threeincision approach (Mc Keown procedure), and 112 patients (43%) underwent surgery by Trans-Hiatal (Oringer). A total of 36 deaths occurred. 22 deaths occurred using Ivor-Lewis (61%), 10 deaths occurred using Mc Keown (27.7%) and 4 deaths occurred after Oringer (11.1%). In terms of prevalence of complications, the most common early complication was pleural effusion (11%) and the most common late complication was anastomotic stricture (17.8%). Conclusions:Complications occurred in all three surgeries. The most complications occurred using transthoracic (Ivor Lewis type) approach and the least complications occurred using Trans-Hiatal (Oringer).

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Immune Responses and Prediction of Major Infection in Patients Undergoing Transhiatal or Transthoracic Esophagectomy for Cancer

Cited by 69 publications

References 33 publications

Mannose-Binding Lectin Deficiency Facilitates AbdominalCandidaInfections in Patients with Secondary Peritonitis

Mannose-Binding Lectin Deficiency Facilitates AbdominalCandidaInfections in Patients with Secondary Peritonitis

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Comparison of Early and Late Complications in Three Esophagectomy Techniques

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