Abstract:Marek's disease virus (MDV) is a highly cell-associated, lymphotropic α-herpesvirus that causes paralysis and neoplastic disease in chickens. The disease has been controlled by vaccination which was provided the first evidence for a malignant cancer being controlled by an antiviral vaccine. Marek's disease pathogenesis is complex, involving cytolytic and latent infection of lymphoid cells and oncogenic transformation of CD4 + T cells in susceptible chickens. MDV targets a number of different cell types during … Show more
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