Immune responses after fractional doses of inactivated poliovirus vaccine using newly developed intradermal jet injectors: A randomized controlled trial in Cuba

Resik, Sonia; Tejeda, Alina; Mach, Ondrej; Fonseca, Magilé; Dı́az, Manuel; Alemany, Nilda; Garcı́a, Gissel; Hung, Lai Heng; Martínez, Yusleidy Correa; Sutter, Roland W.

doi:10.1016/j.vaccine.2014.11.025

Cited by 55 publications

(49 citation statements)

References 14 publications

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“…For polio prime immunization in newborn infants, intradermal 20% IPV dose resulted in similar (4,5) or inferior (31)(32)(33) seroconversion rates compared to a full intramuscular dose. Similarly, for polio booster immunization, intradermal 20% IPV dose resulted in either similar (6,13) or inferior (34,35) seroconversion rates in comparison to full intramuscular dose. However, intradermal immunization generally resulted in significantly lowered antibody titers (5,6,(31)(32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 96%

“…Similarly, for polio booster immunization, intradermal 20% IPV dose resulted in either similar (6,13) or inferior (34,35) seroconversion rates in comparison to full intramuscular dose. However, intradermal immunization generally resulted in significantly lowered antibody titers (5,6,(31)(32)(33)(34)(35). These findings were seemingly not dependent on the intradermal immunization method used, because jet injectors (5,6,31,32,34,35), the Mantoux technique (4,35) or HMN arrays (13,33) evenly resulted in either similar or inferior results to full intramuscular dose.…”

Section: Discussionmentioning

confidence: 96%

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Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

et al. 2016

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Purpose The aim of this study was to investigate the depthdependent intradermal immunogenicity of inactivated polio vaccine (IPV) delivered by depth-controlled microinjections via hollow microneedles (HMN) and to investigate antibody response enhancing effects of IPV immunization adjuvanted with CpG oligodeoxynucleotide 1826 (CpG) or cholera toxin (CT). Methods A novel applicator for HMN was designed to permit depth-and volume-controlled microinjections. The applicator was used to immunize rats intradermally with monovalent IPV serotype 1 (IPV1) at injection depths ranging from 50 to 550 μm, or at 400 μm for CpG and CT adjuvanted immunization, which were compared to intramuscular immunization. Results The applicator allowed accurate microinjections into rat skin at predetermined injection depths (50-900 μm), -volumes (1-100 μL) and -rates (up to 60 μL/min) with minimal volume loss (±1-2%). HMN-mediated intradermal immunization resulted in similar IgG and virus-neutralizing antibody titers as conventional intramuscular immunization. No differences in IgG titers were observed as function of injection depth, however IgG titers were significantly increased in the CpG and CT adjuvanted groups (7-fold).Conclusion Intradermal immunogenicity of IPV1 was not affected by injection depth. CpG and CT were potent adjuvants for both intradermal and intramuscular immunization, allowing effective vaccination upon a minimally-invasive single intradermal microinjection by HMN.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

et al. 2016

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“…A large clinical trial conducted in Cuba included the multipuncture system as a control in a comparative study for three needle-free delivery devices for polio vaccination. In this study, inferior immune responses (defined as seroconversion and increase in virusneutralizing titers) following fractional-IPV dose administered via the ID route compared with full-dose IPV administered IM were reported [26].…”

Section: Traditional Needle-based Dermal Vaccinationmentioning

confidence: 89%

Alternative administration routes and delivery technologies for polio vaccines

Kraan

Stel

Kersten

et al. 2016

Expert Review of Vaccines

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Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery. ARTICLE HISTORY

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“…Various techniques have been used to generate this high velocity jet, such as spring-driven devices (Schramm- Michinaka & Mitragotri 2011;Resik et al 2015), piezo actuation (Arora et al 2007;Stachowiak et al 2009), compressed gas (Shergold et al 2006;Resik et al 2015), Lorentz force actuation (Taberner et al 2012) and laser-induced jet generation (Tagawa et al 2013;Jang et al 2014). Most jet injectors eject volumes of 10 to 500 µl.…”

Section: Introductionmentioning

confidence: 99%

Penetration and delivery characteristics of repetitive microjet injection into the skin

Römgens

Rem-Bronneberg

Kassies

et al. 2016

Journal of Controlled Release

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Immune responses after fractional doses of inactivated poliovirus vaccine using newly developed intradermal jet injectors: A randomized controlled trial in Cuba

Cited by 55 publications

References 14 publications

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

Alternative administration routes and delivery technologies for polio vaccines

Penetration and delivery characteristics of repetitive microjet injection into the skin

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