Immune response to influenza vaccine in adult liver transplant recipients

Duchini, Andrea; Hendry, R. Michael; Nyberg, Lisa M.; Viernes, M. E.; Pockros, Paul J.

doi:10.1053/jlts.2001.23010

Cited by 73 publications

(34 citation statements)

References 6 publications

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“…Previous studies of antibody seroconversion after influenza vaccination ranged from 15%-95% in liver transplant recipients and 56%-100% in healthy controls to the three influenza virus strains (3)(4)10). In a study of 264 health care professionals, overall vaccine response was noted in 57% (41%-78%) of the subjects for the A (H3N2) and in 40% (33%-52%) of subjects for influenza B vaccine (11).…”

Section: Discussionmentioning

confidence: 97%

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Influenza Vaccination in Orthotopic Liver Transplant Recipients: Absence of Post Administration ALT Elevation

Lawal¹,

Basler

Branch³

et al. 2004

American Journal of Transplantation

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Section: Discussionmentioning

confidence: 97%

“…Influenza vaccination has reduced the morbidity and perhaps mortality from influenza virus infection in cirrhotic and post liver transplant patients. Several studies have demonstrated acceptable levels of protective postimmunization antibody titers being achieved post liver transplantation (3,4).…”

Section: Introductionmentioning

confidence: 99%

Influenza Vaccination in Orthotopic Liver Transplant Recipients: Absence of Post Administration ALT Elevation

Lawal¹,

Basler

Branch³

et al. 2004

American Journal of Transplantation

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“…Among persons with kidney or heart transplants, seroresponse rates were similar or slightly reduced compared with healthy persons (232)(233)(234)(235)(236)(237). However, a small study involving participants with liver transplants indicated a reduced immunologic response to influenza vaccinations (238). Response rates were lowest if vaccination occurred within the four months after the transplant procedure (239).…”

Section: Immunocompromised Personsmentioning

confidence: 99%

Prevention and Control of Seasonal Influenza with Vaccines

Grohskopf

Sokolow²,

Broder³

et al. 2016

MMWR Recomm. Rep.

381

279

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“…Data in adult liver transplant recipients are also controver-sial (31,75,77). We recently found that liver recipients had an impaired immune response to the A/Sidney/H3N3 antigen of the 1999 to 2000 trivalent vaccine compared to controls (31).…”

Section: Influenza Vaccinementioning

confidence: 99%

Vaccinations for Adult Solid-Organ Transplant Recipients: Current Recommendations and Protocols

Duchini¹,

Goss²,

et al. 2003

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Recipients of solid-organ transplantation are at risk of severe infections due to their life-long immunosuppression. Despite emerging evidence that vaccinations are safe and effective among immunosuppressed patients, most vaccines are still underutilized in these patients. The efficacy, safety, and protocols of several vaccines in this patient population are poorly understood. Timing of vaccination appears to be critical because response to vaccinations is decreased in patients with end-stage organ disease and in the first 6 months after transplantation. For these reasons, the primary immunizations should be given before transplantation, as early as possible during the course of disease. Vaccination strategy should include vaccination of household contacts and health care workers at transplant centers unless contraindicated. No conclusive data are available on the use of immunoadjuvants and screening for protective titers. Most vaccines appear to be safe in solid-organ transplantation recipients, but live vaccines should be avoided until further studies are available. The risk of rejection appears minimal. Recommended vaccines include pneumovax, hepatitis A and B, influenza, and tetanus-diphtheria. We outline specific protocols and recommendations in this particular patient population. Specific contraindications exist for other vaccines, such as yellow fever, oral polio vaccine, bacillus Calmette-Guerin, and vaccinia. We conclude that solid-organ recipients will benefit from consistent immunization practices. Further studies are recommended to improve established protocols in this patient population

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Immune response to influenza vaccine in adult liver transplant recipients

Cited by 73 publications

References 6 publications

Influenza Vaccination in Orthotopic Liver Transplant Recipients: Absence of Post Administration ALT Elevation

Influenza Vaccination in Orthotopic Liver Transplant Recipients: Absence of Post Administration ALT Elevation

Prevention and Control of Seasonal Influenza with Vaccines

Vaccinations for Adult Solid-Organ Transplant Recipients: Current Recommendations and Protocols

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